Results 171 to 180 of about 24,240 (208)
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CD95-Mediated Calcium Signaling
2017Intracellular calcium signals regulate cell function and cell survival by controlling many processes. CD95 engagement results in distinct intracellular calcium signals that control the cell fate, apoptosis, or survival, depending on the ligand (membrane or soluble).
Mehdi, Hammadi +4 more
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CD95-Mediated Proton Regulation
2017The Na+/H+ exchanger NHE1 is at the crossroads of a large diversity of signaling pathways, whose activation modifies the cooperative response of the transporter to intracellular H+ ions. Here we show how the activation of the Na+/H+ exchanger NHE1 by the cleaved ligand of CD95 can be measured.
Tauzin, Sébastien +9 more
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Characterisation of the roles of CD95 and CD95 ligand in cord blood.
Bone marrow transplantation, 1998The increasing use of umbilical cord blood in transplantation has led to a renewed interest in the immunological characterisation of this material. This study addresses the question of whether the CD95 molecule and its ligand are expressed and are functional in mediating cell death in cord blood mononuclear cells. These molecules have a crucial role in
B, Drénou +6 more
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The role of CD95 system in chemotherapy
Drug Resistance Updates, 1999Chemotherapy of malignant tumors, including acute leukemias, is largely based on empirical data and clinical experience. In recent years, it has become clear that anticancer drugs induce apoptosis in target cells. Activation of the CD95 system initiated by induction of CD95 ligand/receptor interaction has been shown to contribute to drug-induced ...
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Understanding Life and Death at CD95
2010CD95 (APO-1/Fas) is a member of the death receptor (DR) family, a subfamily of the TNF-R (tumor necrosis factor receptor) superfamily. Engagement of CD95 leads to the induction of the apoptotic and non-apoptotic signaling pathways. Here we addressed the question of crosstalk between CD95-induced apoptosis and NF-κB activation.
Carina, Pforr +4 more
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Immune (dys)regulation in multiple sclerosis: role of the CD95–CD95 ligand system
Immunology Today, 1999Abstract T cells specific for myelin antigens are thought to initiate and perpetuate the immune process behind multiple sclerosis. Apoptosis is a key regulatory mechanism that determines T-cell fate and might mediate tissue damage. Here, Frauke Zipp, Peter Krammer and Michael Weller discuss the role of the CD95–CD95 ligand system in multiple sclerosis.
F, Zipp, P H, Krammer, M, Weller
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CD95/CD95 Ligand-Mediated Counterattack Does Not Block T Cell Cytotoxicity
Biochemical and Biophysical Research Communications, 2000Expression of CD95 ligand on parenchymal, epithelial, or tumor cells has been suggested to downregulate the immune response and to control lymphocyte activation. Suppression might be mediated by induction of apoptosis or by inhibition of Ca(2+) channels upon CD95 triggering.
A, Jekle +4 more
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Hyperosmotic Activation of the CD95 System
2007Cell shrinkage, nuclear condensation, DNA fragmentation, and apoptotic body formation are hallmarks of programmed apoptotic cell death. Herein, apoptotic volume decrease (AVD) is an early and ubiquitous event. Conversely, in hepatocytes, hyperosmotic cell shrinkage leads to an activation of the CD95 death receptor system, which involves CD95 tyrosine ...
Roland, Reinehr, Dieter, Häussinger
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Principles and mechanisms of CD95 activation
Biological Chemistry, 2014Abstract CD95 (Apo1/Fas) has been originally identified as the target of cell death-inducing antibodies. The recognition of CD95 as an apoptosis-triggering receptor represents one of the early milestones in the apoptosis field. Moreover, the research on CD95-induced cell death fostered various other discoveries of broad and general relevance in cell ...
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