Results 291 to 300 of about 1,696,937 (352)

A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Background Individuals with serum elevations of anti‐cyclic citrullinated peptide (anti‐CCP) antibodies are at increased risk for future rheumatoid arthritis (RA). No pharmacologic interventions have been approved for the prevention of RA in such ‘at‐risk’ individuals. However, hydroxychloroquine (HCQ) is used without supporting clinical trial evidence.
Kevin D. Deane, Christopher C. Striebich, Marie L. Feser, James R. O'Dell, Judith A. James, Jeffrey A. Sparks, John M. Davis, Jonathan Graf, Maureen A. McMahon, Elizabeth B. Solow, Lindsy Forbess, Athan Tiliakos, Elena Schiopu, Maria I. Danila, Diane L. Horowitz, Jonathan Kay, Colin D. Strickland, Joel M. Guthridge, Cristina Arriens, Jennifer M. Grossman, M. Kristen Demoruelle, Elizabeth A. Bemis, Ashley Frazer‐Abel, Chelsie L. Fleischer, David A. Fox, Ted R. Mikuls, Melissa Greenleaf, Kate York, Sarah Walker, Lynette Keyes‐Elstein, Margie Byron, Janel Fedler, Ellen A. Goldmuntz, V. Michael Holers   +33 more
wiley   +1 more source

<i>Fusobacterium nucleatum</i> drives CD40-mediated dendritic cell activation and Th17/Treg imbalance to exacerbate intestinal inflammation in Crohn's disease. [PDF]

Front Immunol
Wang M, Sun J, Yu J, Wang J, Xu C, Ma J, Zhang H.   +6 more
europepmc   +1 more source

Reactive Oxygen Species–Induced Modifications of Fibrin Clots as a Link Between Immune Responses and Atherothrombosis in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Cardiovascular events are major determinants of morbidity and mortality in systemic lupus erythematosus (SLE), particularly in patients with renal involvement. Although oxidative stress has been implicated in driving vascular and renal damage in SLE, the specific mechanisms remain unclear.
Matteo Becatti, Giacomo Emmi, Alessandra Bettiol, Amanda Mannucci, Flavia Rita Argento, Eleonora Fini, Serena Borghi, Francesca Nencini, Maria Nicastro, Irene Mattioli, Elena Silvestri, Augusto Vaglio, Domenico Prisco, Claudia Fiorillo   +13 more
wiley   +1 more source

Rapid High-Sensitivity Detection of Antibodies to Trypanosoma cruzi With a Recombinant Tc24 Antigen-Based Magneto-Immunoassay: A Pilot Study. [PDF]

J Infect Dis
Singampalli KL, Zhan B, Mejia R, Lillehoj PB.   +3 more
europepmc   +1 more source

Cytokine pathways driving diverse tissue pathologies in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Rheumatoid arthritis is a complex systemic disorder characterised primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease e.g. of the lung with potentially devastating clinical consequences.
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

CAR T-cell therapy for neurological disorders: scientific rationale and mechanistic insights. [PDF]

Ther Adv Neurol Disord
Katsaros DE, Mougiakakos D.
europepmc   +1 more source

Distinct HLA Associations for Antibody Multireactivity With Citrulline‐Containing Type II Collagen Epitopes Versus More Limited Antibody Reactivity With Citrulline‐Containing IgG Epitopes in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anticitrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) can be promiscuous, with cross‐reactive binding to many antigens containing short motifs, or private with little cross‐reactivity. Also, ACPA reactivity patterns differ among patients with RA, including for motif‐containing epitopes in important self‐antigens like ...
S. Janna Bashar, Courtney B. Myhr, Adam H. Titi, Zihao Zheng, Miriam A. Shelef   +4 more
wiley   +1 more source

T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history. [PDF]

Commun Biol
ElAbd H, Mahdy AKH, Wacker EM, Gretsova M, Ellinghaus D, Dempfile A, Franke A.   +6 more
europepmc   +1 more source

Immunological Profiling suggests an Association between Treg dysfunction and Pain in Knee Osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Background Pain is the hallmark symptom of osteoarthritis (OA) and its biological drivers remain poorly understood. While the role of innate immunity in OA has been extensively studied, the involvement of adaptive immunity, in particular regulatory T cells (Tregs), is not well understood. Methods We performed omics profiling of peripheral blood from 46
Marie Binvignat, Johanna Dubois, Maria Marco Salvador, Paul Stys, Fabien Pitoiset, Alexandra Roux, Michèle Sastre, Signe Hassler, Roberta Lorenzon, Claire Ribet, Vanessa Mhanna, Hélène Vantomme, Leslie Adda, Pierre Barennes, Nicolas Coatnoan, Kenz Le Gouge, Caroline Aheng, Alice Courties, Lise Minssen, Atul J. Butte, Adrien Six, Michelle Rosenzwajg, Nicolas Tchitchek, Francis Berenbaum, David Klatzmann, Encarnita Mariotti‐Ferrandiz, Jérémie Sellam   +26 more
wiley   +1 more source

Oral Manifestations in Children with Celiac Disease - Part II: Salivary Changes, Immunological Markers, and their Correlation with Oral Health Status. [PDF]

Med Princ Pract
Acar S, Aksu G, Hameş EE, Karakoyun M, Aydoğdu S.   +4 more
europepmc   +1 more source