Results 41 to 50 of about 301,057 (248)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Antecedentes y evolución: el libro de texto y su presencia en la probabilidad

RECIE Revista Electrónica Científica de Investigación Educativa, 2018
Se describen los antecedentes identificados y su evolución para fundamentar un proyecto de investigación en desarrollo. Se parte de la concepción que se tiene de un libro de texto, como recurso por excelencia dentro del aula.
María Teresa Martínez Acosta, Alberto Camacho Ríos   +1 more
doaj  

ADSORCIÓN DE IONES Cd (II) EN TALQUITA

Revista Centro Azúcar, 2021
Introducción: La talquita consta de paquetes alternados de tres capas con enlaces débiles de Van der Waals entre ellos. La capa octaédrica se encuentra entre dos capas tetraédricas.
Julio Omar Prieto García, Rafael Quintana Puchol, Pedro Cesar Quero Jiménez, Daimel Castillo González, Omar Casanova Álvarez, Mixary Enríquez García   +5 more
doaj  

OPTIMALISASI TRANSPORT SELEKTIF ION Ni(II) TERHADAP Cd(II) DENGAN ZAT PEMBAWA OKSIN MELALUI TEKNIK MEMBRAN CAIR FASA RUAH SECARA SIMULTAN

Jurnal Riset Kimia, 2015
The selective transport of Ni(II) to Cd(II) through simultaneously liquid membrane technique has been investigated. The cell membrane was made by mixturing Ni(II) and Cd(II) ions at concentration as 3.41x10-4 M and 1.78x10-4 M respectively as source ...
Vera Tri Ningsih, Admin Alif, Hermansyah Aziz   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effects of Pyrolysis Temperatures and Modified Methods on Rice Husk-Derived Biochar Characteristics and Heavy Metal Adsorption

Molecules
Biochars were prepared from rice husk at different pyrolysis temperatures (300, 400, and 500 °C) and then modified by nitric acid (HNO3) and potassium hydroxide (KOH). The chemical and physical properties were characterized, and the adsorption ability of
Zhaoqin Huang, Qin Wang, Yufeng Zhang, Buyun Du, Jun Zhou, Dongliang Ji   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Co-Removal Effect and Mechanism of Cr(VI) and Cd(II) by Biochar-Supported Sulfide-Modified Nanoscale Zero-Valent Iron in a Binary System

Molecules, 2022
This study aimed to explore the co-removal effect and mechanism of Cr(VI) and Cd(II) with an optimized synthetic material. The toxicity and accumulation characteristics of Cr(VI) and Cd(II) encountered in wastewater treatment areas present significant ...
Rui Zhao, Xiufeng Cao, Tao Li, Xiaowei Cui, Zhaojie Cui   +4 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Adsorpsi Ion Logam Mg(II) Menggunakan Kitosan Termodifikasi Asam Askorbat

Jurnal Kimia Sains dan Aplikasi, 2014
Modifikasi kitosan-asam askorbat dan pemanfaatannya sebagai adsorben ion logam Mg(II), ion logam Cd(II), dan campuran ion logam Mg(II)-Cd(II), juga dilakukan penentuan pH dan waktu kontak optimum untuk adsorpsi ion Mg(II), serta mengetahui kemampuan ...
Wawan Prasetyo, Khabibi Khabibi, Didik Setiyo Widodo   +2 more
doaj   +1 more source