Results 1 to 10 of about 18,977 (237)

NSUN4 Facilitates the Activity of Oncogenic Protein CDC20 to Promote NSCLC Development by Mediating m5C Modification of CDC20 mRNA [PDF]

Thoracic Cancer
Background 5‐methylcytosine (m5C) methylation is the crucial posttranscriptional modification of RNA. NSUN4, a methyltransferase for m5C methylation, contributes to lung tumorigenesis. Here, we determined the precise action of NSUN4 on the development of
Zhilong Li, Xianzhen Wu
doaj   +4 more sources

Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly [PDF]

Nature Communications, 2022
Formation of the mitotic checkpoint complex (MCC) is catalysed by a phosphorylation-dependent scaffold. This work provides structural details of how a tripartite Mad1:Bub1:Cdc20 complex presents Cdc20 to Mad2, triggering open-to-closed conversion of Mad2
Elyse S. Fischer, Conny W. H. Yu, Johannes F. Hevler, Stephen H. McLaughlin, Sarah L. Maslen, Albert J. R. Heck, Stefan M. V. Freund, David Barford   +7 more
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Regulated degradation of the APC coactivator Cdc20 [PDF]

Cell Division, 2010
Background Cdc20 is a highly conserved activator of the anaphase-promoting complex (APC), promoting cell-cycle-regulated ubiquitination and proteolysis of a number of critical cell-cycle-regulatory targets including securin and mitotic cyclins. APC-Cdc20
Robbins Jonathan A, Cross Frederick R
doaj   +3 more sources

Overexpression of CDC20 Confer a Poorer Prognosis in Bladder Cancer Identified by Gene Co-Expression Network Analysis [PDF]

Diagnostics
Background/Objectives: Bladder cancer (BCa) ranks as the tenth most prevalent malignancy worldwide, characterized by high morbidity and mortality rates.
Xuejian Yang, Yunjie Guo, Lanyu Wang, Zengli Miao, Xiaojie Lu, Jun Ruan, Wei Tian   +6 more
doaj   +2 more sources

CDC20 protects the heart from doxorubicin-induced cardiotoxicity by modulating CCDC69 degradation [PDF]

Cellular & Molecular Biology Letters
Aims Doxorubicin (DOX) is a potent anticancer drug; however, it is associated with significant cardiotoxicity. CDC20 is an E3 ubiquitin ligase that plays a role in cell cycle progression and apoptosis in various types of cancers. The involvement of CDC20
Zhenyu Feng, Ningning Zhang, Liang Wang, Xumin Guan, Yunpeng Xie, Yun-long Xia   +5 more
doaj   +2 more sources

Cell division cycle 20 promotes tumor progression and predicts poor clinical outcome in childhood and adult adrenocortical carcinoma [PDF]

Journal of Clinical & Translational Endocrinology
Background: Adrenocortical carcinoma (ACC) is an uncommon and highly aggressive tumor with a grim prognosis. Numerous investigations have elucidated a close association between the dysregulated expression of multiple genes within tumors and the ...
Jiahong Chen, Peisheng Huang, Yongcheng Shi, Shanshan Mo, Cheng-Ya Hsu, Shumin Fang, Chuanfan Zhong, Le Zhang, Lanting Zuo, Jianming Lu, Weide Zhong, Zhuoya Huang, Zhong Dong   +12 more
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A signature of correlated CDC20 and UBCH10 expression indicates poor prognosis in primary head and neck squamous cell carcinoma [PDF]

BMC Cancer
Background The orchestration of mitotic checkpoint execution depends on the enzymatic activity of the anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase.
Ratnadip Paul, Sayani Sinharay, Debanil Dhar, Purandar Sarkar, Puja Chakraborty, Saradindu Ghosh, Anup Roy, Abhik Saha, Susanta Roychoudhury, Somsubhra Nath   +9 more
doaj   +2 more sources

The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium [PDF]

eLife, 2014
The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, such as control of growth and ...
Weiping Wang, Tao Wu, Marc W Kirschner
doaj   +3 more sources

Based on machine learning, CDC20 has been identified as a biomarker for postoperative recurrence and progression in stage I & II lung adenocarcinoma patients

Frontiers in Oncology
ObjectiveBy utilizing machine learning, we can identify genes that are associated with recurrence, invasion, and tumor stemness, thus uncovering new therapeutic targets.MethodsTo begin, we obtained a gene set related to recurrence and invasion from the ...
Rui Miao, Rui Miao, Rui Miao, Zhi Xu, Zhi Xu, Tao Han, Tao Han, Yafeng Liu, Yafeng Liu, Jiawei Zhou, Jiawei Zhou, Jianqiang Guo, Jianqiang Guo, Yingru Xing, Yingru Xing, Ying Bai, Ying Bai, Zhonglei He, Zhonglei He, Jing Wu, Jing Wu, Wenxin Wang, Wenxin Wang, Dong Hu, Dong Hu, Dong Hu   +25 more
doaj   +2 more sources

Parallel Parkin: Cdc20 Takes a New Partner [PDF]

Molecular Cell, 2015
CDC20 and CDH1 are well-established substrate receptors for the Anaphase Promoting Complex/Cyclosome (APC/C). In this issue of Molecular Cell, Lee et al. (2015) show that these adaptors can also target cell cycle proteins for destruction through a second ubiquitin ligase, Parkin.
Fernando Meza-Gutierrez, Frances V Hundley, David P. Toczyski   +2 more
openalex   +5 more sources