CDC20 and CCNB1 Overexpression as Prognostic Markers in Bladder Cancer [PDF]
DiagnosticsBackground: Bladder cancer (BC) is one of the ten most common cancers worldwide, with a high recurrence rate and significant variation in clinical outcomes based on tumor grade and stage.
Hatice Sevim Nalkiran +5 more
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CDC20 protects the heart from doxorubicin-induced cardiotoxicity by modulating CCDC69 degradation [PDF]
Cellular & Molecular Biology LettersAims Doxorubicin (DOX) is a potent anticancer drug; however, it is associated with significant cardiotoxicity. CDC20 is an E3 ubiquitin ligase that plays a role in cell cycle progression and apoptosis in various types of cancers. The involvement of CDC20
Zhenyu Feng +5 more
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Cell division cycle 20 promotes tumor progression and predicts poor clinical outcome in childhood and adult adrenocortical carcinoma [PDF]
Journal of Clinical & Translational EndocrinologyBackground: Adrenocortical carcinoma (ACC) is an uncommon and highly aggressive tumor with a grim prognosis. Numerous investigations have elucidated a close association between the dysregulated expression of multiple genes within tumors and the ...
Jiahong Chen +12 more
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NSUN4 Facilitates the Activity of Oncogenic Protein CDC20 to Promote NSCLC Development by Mediating m5C Modification of CDC20 mRNA [PDF]
Thoracic CancerBackground 5‐methylcytosine (m5C) methylation is the crucial posttranscriptional modification of RNA. NSUN4, a methyltransferase for m5C methylation, contributes to lung tumorigenesis. Here, we determined the precise action of NSUN4 on the development of
Zhilong Li, Xianzhen Wu
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A signature of correlated CDC20 and UBCH10 expression indicates poor prognosis in primary head and neck squamous cell carcinoma [PDF]
BMC CancerBackground The orchestration of mitotic checkpoint execution depends on the enzymatic activity of the anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase.
Ratnadip Paul +9 more
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A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.
PLoS Pathogens, 2012 Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC/C ...
David S Guttery +13 more
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The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium [PDF]
eLife, 2014 The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, such as control of growth and ...
Weiping Wang, Tao Wu, Marc W Kirschner
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The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation [PDF]
Nature Communications, 2016 The mitotic checkpoint complex (MCC) inhibits the anaphase-promoting complex (APC/C) bound to Cdc20 in response to spindle defects. Here, the authors show that Bub1-Plk1-mediated phosphorylation of Cdc20 constitutes a parallel, non-redundant APC/C ...
Luying Jia, Bing Li, Hongtao Yu
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Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]
, 2014 The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
Corbishley, Stephen +5 more
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Frontiers in Oncology, 2021 The landscape of CDC20 gene expression and its biological impacts across different types of cancers remains largely unknown. Here, a pan-cancer analysis was performed to analyze the role of Cdc20 in various human cancers.
Fei Wu +8 more
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