Results 1 to 10 of about 20,775 (267)
CDC20 and CCNB1 Overexpression as Prognostic Markers in Bladder Cancer [PDF]
DiagnosticsBackground: Bladder cancer (BC) is one of the ten most common cancers worldwide, with a high recurrence rate and significant variation in clinical outcomes based on tumor grade and stage.
Hatice Sevim Nalkiran +5 more
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Discovery of Ureido-Based Apcin Analogues as Cdc20-specific Inhibitors against Cancer [PDF]
Pharmaceuticals, 2023 Cdc20 is a promising drug target that plays an important role in the mid-anaphase process of cellular mitosis, and Apcin is the only reported core structure of the Cdc20-specific inhibitor.
Yiqin He +4 more
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CDC20 protects the heart from doxorubicin-induced cardiotoxicity by modulating CCDC69 degradation [PDF]
Cellular & Molecular Biology LettersAims Doxorubicin (DOX) is a potent anticancer drug; however, it is associated with significant cardiotoxicity. CDC20 is an E3 ubiquitin ligase that plays a role in cell cycle progression and apoptosis in various types of cancers. The involvement of CDC20
Zhenyu Feng +5 more
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The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium [PDF]
eLife, 2014 The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, such as control of growth and ...
Weiping Wang, Tao Wu, Marc W Kirschner
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Journal of Experimental & Clinical Cancer Research, 2022 Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it controls the correct segregation of chromosomes during mitosis. Many studies have focused on the biological role of CDC20 in cancer development, as alterations of its
Samantha Bruno +5 more
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CDC20 Is Regulated by the Histone Methyltransferase, KMT5A, in Castration-Resistant Prostate Cancer [PDF]
Cancers, 2023 Simple Summary The methyltransferase KMT5A is suggested as an oncogene in prostate cancer but the mechanisms underlying its oncogenic properties are poorly understood.
Zainab Adnan Hatem Alebady +11 more
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Experimental Hematology & Oncology, 2023 Background Increasing evidence suggests that immunotherapy, especially immune checkpoint inhibitors (ICIs), has the potential to facilitate long-term survival in various cancer besides prostate cancer.
Fei Wu +8 more
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Experimental Hematology & Oncology, 2023 Background Cell cycle dysregulation characterized by cyclin D1 overexpression is common in mantle cell lymphoma (MCL), while mitotic disorder was less studied. Cell division cycle 20 homologue (CDC20), an essential mitotic regulator, was highly expressed
Yingtong Chen +9 more
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Kaohsiung Journal of Medical Sciences, 2022 Cell division cycle 20 (CDC20) and microRNAs (miRNAs) are differentially expressed in non‐small cell lung cancer (NSCLC). The current study aimed to investigate the role of miR‐1321 and miR‐7515 regulation in CDC20 during NSCLC development.
Hao Hu +7 more
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Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling
Communications Biology, 2023 Accurate mitosis is coordinated by the spindle assembly checkpoint (SAC) through the mitotic checkpoint complex (MCC), which inhibits the anaphase-promoting complex or cyclosome (APC/C).
Yuqing Zhang +10 more
doaj +2 more sources