Epirubicin Induces Cell Cycle Arrest in Multiple Myeloma Cells by Downregulating CDC20 Expression
Frontiers in Bioscience-LandmarkBackground: Although epirubicin is used among therapeutic options for multiple myeloma (MM), its clinical use remains limited, in part because the subgroup of patients most likely to benefit has not been clearly defined.
Zhen Nan +4 more
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Conserved CDC20 cell cycle functions are carried out by two of the five isoforms in Arabidopsis thaliana. [PDF]
PLoS ONE, 2011 The CDC20 and Cdh1/CCS52 proteins are substrate determinants and activators of the Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligase and as such they control the mitotic cell cycle by targeting the degradation of various cell cycle ...
Zoltán Kevei +7 more
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A Cdc20-APC Ubiquitin Signaling Pathway Regulates Presynaptic Differentiation [PDF]
Science, 2009 Cdc20-APC in Synapse Formation The E3 ubiquitin ligase Cdc20-anaphase promoting complex (Cdc20-APC) has important roles in the control of the cell division cycle. Yang et al. (p.
Yue Yang +8 more
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Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome [PDF]
, 2011 The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that regulates progression through the cell cycle by marking key cell division proteins for destruction.
Berckmans, Barbara +9 more
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HPV42 – a human papillomavirus classified as a low‐risk type with oncogenic potential
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Human papillomavirus (HPV) type 42 is a rare HPV type currently classified as “low‐risk” and belongs to the alpha genus. It has primarily been detected in benign vulvar papillomas and is predominantly associated with benign lesions such as anogenital warts.
Sven Niklas Burmann +7 more
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Interphase APC/C–Cdc20 inhibition by cyclin A2–Cdk2 ensures efficient mitotic entry
Nature Communications, 2016 The Anaphase Promoting Complex/Cyclosome (APC/C) and its co-activator Cdc20 regulate mitotic progression, but both are also present in interphase. Here Hein and Nilsson show that Cyclin A2–CDK2 phosphorylates Cdc20 to inhibit APC/C–Cdc20 activity during ...
Jamin B. Hein, Jakob Nilsson
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Mitotic Cdc6 Stabilizes Anaphase-Promoting Complex Substrates by a Partially Cdc28-Independent Mechanism, and This Stabilization Is Suppressed by Deletion of Cdc55 [PDF]
, 2006 Ectopic expression of Cdc6p results in mitotic delay, and this has been attributed to Cdc6p-mediated inhibition of Cdc28 protein kinase and failure to activate the anaphase-promoting complex (APC).
Boronat, Susanna, Campbell, Judith L.
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Molecular pathology of phyllodes tumours of the breast—much more than MED12
Histopathology, EarlyView.Phyllodes tumours can develop from fibroadenomas bearing MED12 variants by the development of pTERT alterations (“MED12 pathway”) or de novo (“MED12 independent pathway”). Grade progression is associated with increasing genetic complexity including cancer driver gene aberrations. Molecular alterations can be useful in assigning grade and distinguishing
Jia‐Min B Pang +3 more
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Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control
Computational and Structural Biotechnology Journal, 2015 The spindle checkpoint assembly (SAC) ensures genome fidelity by temporarily delaying anaphase onset, until all chromosomes are properly attached to the mitotic spindle.
Bashar Ibrahim
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, 2005 Specific HPV DNA sequences are associated with more than 90% of invasive carcinomas of the uterine cervix. Viral E6 and E7 oncogenes are key mediators in cell transformation by disrupting TP53 and RB pathways. To investigate molecular mechanisms involved
Anne de La Rochefordière +15 more
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