Results 101 to 110 of about 18,904 (232)
Advanced Science, Volume 13, Issue 3, 14 January 2026.This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang +13 more
wiley +1 more source
Control of APC-Cdc20 by the Tumor Suppressor RASSF1A [PDF]
Cell Cycle, 2004 The tumor suppressor gene RASSF1A is frequently hypermethylated in various tumors. However, how RASSF1A functions in tumor suppression was unknown. Our study shows that RASSF1A regulates the stability of mitotic cyclins and the timing of mitotic progression by inhibiting APC-Cdc20.
Song, MS Song, Min Sup +1 more
openaire +2 more sources
Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy. [PDF]
PLoS Pathogens, 2018 Shugoshin-1 (Sgo1) protects the integrity of the centromeres, and H2A phosphorylation is critical for this process. The mitotic checkpoint kinase Bub1, phosphorylates H2A and ensures fidelity of chromosome segregation and chromosome number.
Fengchao Lang +5 more
doaj +1 more source
Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome [PDF]
, 2011 The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that regulates progression through the cell cycle by marking key cell division proteins for destruction.
Berckmans, Barbara +9 more
core +2 more sources
Advanced Science, Volume 13, Issue 4, 19 January 2026.LZU‐WZLYCS01 is a novel FGFR3‐targeting ADC for bladder cancer with 7‐ethyl‐9‐fluorocamptothecin (A2) as its cytotoxic payload. LZU‐WZLYCS01 intracellularly releases A2, which targets MAD2L1 to activate the cGAS‐STING pathway and induce tumor cell apoptosis.
Shu Cui +16 more
wiley +1 more source
Cdc20 in S-phase: The Banquo at Replication’s Banquet [PDF]
Cell Cycle, 2004 The Anaphase Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase that covalently attaches ubiquitins onto proteins to target them for proteolysis by the 26S proteasome. During mitosis, the APC/C is instrumental in allowing the cell to enter and exit from mitosis. The APC/C accomplishes this by using different specificity factors to recognize,
Catherine A, Andrews +3 more
openaire +2 more sources
Edge usage, motifs and regulatory logic for cell cycling genetic networks
, 2013 The cell cycle is a tightly controlled process, yet its underlying genetic network shows marked differences across species. Which of the associated structural features follow solely from the ability to impose the appropriate gene expression patterns?
Krzywicki, A. +2 more
core +3 more sources
LSF small molecule inhibitors phenocopy LSF-targeted siRNAs causing mitotic defects and senescence in cancer cells [PDF]
, 2019 The oncogene LSF has been proposed as a novel target with therapeutic potential for multiple cancers. LSF overexpression correlates with poor prognosis for both liver and colorectal cancers, for which there are currently limited therapeutic treatment ...
Chin, Hang Gyeong +10 more
core +1 more source
Cdc20 protects cells from Ara-c-induced apoptosis in AML via targeting autophagy [PDF]
, 2021 Shumin Ding +8 more
openalex +1 more source
Advanced Science, Volume 13, Issue 3, 14 January 2026.This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui +10 more
wiley +1 more source