Results 101 to 110 of about 20,775 (267)

CDC20 Holds Novel Regulation Mechanism in RPA1 during Different Stages of DNA Damage to Induce Radio-Chemoresistance

International Journal of Molecular Sciences
Targeting CDC20 can enhance the radiosensitivity of tumor cells, but the function and mechanism of CDC20 on DNA damage repair response remains vague. To examine that issue, tumor cell lines, including KYSE200, KYSE450, and HCT116, were utilized to detect
Yang Gao, Pengbo Wen, Chenran Shao, Cheng Ye, Yuji Chen, Junyu You, Zhongjing Su   +6 more
semanticscholar   +1 more source

The bioinformatics and experimental analysis of the novel roles of virus infection-associated gene CDC20 for prognosis and immune infiltration in hepatocellular carcinoma

Aging, 2022
Infection virus including HBV and HCV has been well recognized as a major cause inducing hepatocellular carcinoma (HCC). However, molecular investigations into the HTLV-1 (Human T-lymphotropic virus type-1) and HCC have been rare.
Juanni Li, Xiaofang Zhang, Lei Yao, K. Hu   +3 more
semanticscholar   +1 more source

A Novel FGFR3‐Targeting Antibody‐Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder Cancer

Advanced Science, EarlyView.
LZU‐WZLYCS01 is a novel FGFR3‐targeting ADC for bladder cancer with 7‐ethyl‐9‐fluorocamptothecin (A2) as its cytotoxic payload. LZU‐WZLYCS01 intracellularly releases A2, which targets MAD2L1 to activate the cGAS‐STING pathway and induce tumor cell apoptosis.
Shu Cui, Xiongfei Luo, Guangrui Fan, Jingqi Jiang, Yingru Wang, Enguang Yang, Jinpeng Ma, Ze Zhang, Yuhan Wang, Juan Wang, Dengtuo Wang, Hanzhang Wang, Liang Cheng, Junqiang Tian, Zhilong Dong, Yingqian Liu, Zhiping Wang   +16 more
wiley   +1 more source

Dual inhibition of Cdc20 by the spindle checkpoint

Journal of Biomedical Science, 2007
The metaphase-to-anaphase transition is triggered by the Anaphase-Promoting Complex (APC), an E3 ubiquitin ligase that targets proteins for degradation, leading to sister chromatid separation and mitotic exit. The function of APC is controlled by the spindle checkpoint that delays anaphase onset in the presence of any chromosome that has not ...
openaire   +2 more sources

Ubiquitination of Cdc20 by the APC Occurs through an Intramolecular Mechanism [PDF]

Current Biology, 2011
Cells control progression through late mitosis by regulating Cdc20 and Cdh1, the two mitotic activators of the anaphase-promoting complex (APC). The control of Cdc20 protein levels during the cell cycle is not well understood.Here, we demonstrate that Cdc20 is degraded in budding yeast by multiple APC-dependent mechanisms.
Foe, Ian T., Foster, Scott A., Cheung, Stephanie K., DeLuca, Steven Z., Morgan, David O., Toczyski, David P.   +5 more
openaire   +2 more sources

Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by temporal inhibition of the anaphase-promoting complex/cyclosome [PDF]

, 2011
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that regulates progression through the cell cycle by marking key cell division proteins for destruction.
Berckmans, Barbara, Boudolf, Véronique, De Jaeger, Geert, De Veylder, Lieven, De Wit, Kevin, Heyman, Jefri, Koncz, Csaba, Lessa Alvim Kamei, Claire, Van Den Daele, Hilde, Verkest, Aurine   +9 more
core   +2 more sources

Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer.

Cancer Research, 2022
CDC20 is a co-activator of the anaphase promoting complex/cyclosome (APC/C) and is essential for mitotic progression. APC/CCDC20 is inhibited by the spindle assembly checkpoint (SAC), which prevents premature separation of sister chromatids and ...
Owen J. Chen, E. Castellsagué, M. Moustafa-Kamal, J. Nadaf, B. Rivera, S. Fahiminiya, Yilin Wang, Isabelle Gamache, Caterina Pacifico, Lai Jiang, Jian Carrot-Zhang, L. Witkowski, A. Berghuis, Stefan Schoenberger, D. Schneider, Morten Hillmer, S. Bens, R. Siebert, C. J. Stewart, Ziguo Zhang, William C H Chao, Celia M. T. Greenwood, David Barford, M. Tischkowitz, Jacek Majewski, W. Foulkes, J. G. Teodoro   +26 more
semanticscholar   +1 more source

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

Advanced Science, EarlyView.
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang, Xiaoyu Chen, Shengpeng Shao, Xue Liang, Jun Xu, Yi Sun, Xiufang Xiong, Yongchao Zhao   +10 more
wiley   +1 more source

Conserved CDC20 cell cycle functions are carried out by two of the five isoforms in Arabidopsis thaliana. [PDF]

PLoS ONE, 2011
The CDC20 and Cdh1/CCS52 proteins are substrate determinants and activators of the Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligase and as such they control the mitotic cell cycle by targeting the degradation of various cell cycle ...
Zoltán Kevei, Mikhail Baloban, Olivier Da Ines, Hilda Tiricz, Alexandra Kroll, Krzysztof Regulski, Peter Mergaert, Eva Kondorosi   +7 more
doaj   +1 more source

A Method to Identify and Analyze Biological Programs through Automated Reasoning. [PDF]

, 2016
Predictive biology is elusive because rigorous, data-constrained, mechanistic models of complex biological systems are difficult to derive and validate.
and Stephen Emmott, 5, Austin Smith, 2, Boyan Yordanov, 1, Hillel Kugler, 1, Martello, Graziano, Sara-Jane Dunn, 1   +5 more
core   +1 more source