Results 101 to 110 of about 20,500 (223)

Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy. [PDF]

PLoS Pathogens, 2018
Shugoshin-1 (Sgo1) protects the integrity of the centromeres, and H2A phosphorylation is critical for this process. The mitotic checkpoint kinase Bub1, phosphorylates H2A and ensures fidelity of chromosome segregation and chromosome number.
Fengchao Lang, Zhiguo Sun, Yonggang Pei, Rajnish Kumar Singh, Hem Chandra Jha, Erle S Robertson   +5 more
doaj   +1 more source

Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I [PDF]

, 2013
Sexually reproducing organisms halve their cellular ploidy during gametogenesis by undergoing a specialized form of cell division known as meiosis. During meiosis, a single round of DNA replication is followed by two rounds of nuclear divisions (referred
A Petrovic, A Toth, AL Marston, AP Joglekar, C Michaelis, C Rumpf, E Screpanti, Eva Hoffmann, GW Kerr, GW Kerr, IL Brito, J Fernius, J Gregan, J Huang, J Matos, J Wong, Jacob Z. Dalgaard, Jonathan B. A. Millar, K Johzuka, K Tada, K Tanaka, KD Corbett, KD Corbett, KP Rabitsch, Louise Newnham, M Petronczki, M Petronczki, MR Przewloka, N Grandin, P Hieter, P Hornung, Prakash Arumugam, Rajesh T. Shenoy, RK Clyne, S Keeney, S Santaguida, S Westermann, SB Buonomo, Sourav Sarkar, Sue Biggins, X Li   +40 more
core   +3 more sources

PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B [PDF]

, 2022
Zhaotao Wang, Ji Wang, Zongyu Xiao, Peng Li, Chunwang Wu, Yan Li, Qing Wang, Yanming Chen, Honglong Zhou, Zhi Li, Qing Lan, Yezhong Wang   +11 more
openalex   +1 more source

Six Drivers of Aging Identified Among Genes Differentially Expressed With Age

Aging Cell, EarlyView.
A meta‐analysis of 25 transcriptomic datasets from mammalian tissues revealed 45 genes consistently upregulated or downregulated with age. Orthologs of these genes were functionally evaluated using Caenorhabditis elegans lifespan screens to reveal those with causal roles in the aging process, thus identifying six evolutionarily conserved drivers of ...
Ariella Coler‐Reilly, Zachary Pincus, Erica L. Scheller, Roberto Civitelli   +3 more
wiley   +1 more source

The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis [PDF]

, 2018
PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes.
Lucas, Millikin, Narendra, Santel, Zhang
core   +2 more sources

HPV42 – a human papillomavirus classified as a low‐risk type with oncogenic potential

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Human papillomavirus (HPV) type 42 is a rare HPV type currently classified as “low‐risk” and belongs to the alpha genus. It has primarily been detected in benign vulvar papillomas and is predominantly associated with benign lesions such as anogenital warts.
Sven Niklas Burmann, Ulrike Wieland, Steffi Silling, Frank Oellig, David Chromy, Julia Hyun, Thilo Gambichler, Alexander Kreuter   +7 more
wiley   +1 more source

Edge usage, motifs and regulatory logic for cell cycling genetic networks

, 2013
The cell cycle is a tightly controlled process, yet its underlying genetic network shows marked differences across species. Which of the associated structural features follow solely from the ability to impose the appropriate gene expression patterns?
Krzywicki, A., Martin, O. C., Zagorski, M.   +2 more
core   +3 more sources

LSF small molecule inhibitors phenocopy LSF-targeted siRNAs causing mitotic defects and senescence in cancer cells [PDF]

, 2019
The oncogene LSF has been proposed as a novel target with therapeutic potential for multiple cancers. LSF overexpression correlates with poor prognosis for both liver and colorectal cancers, for which there are currently limited therapeutic treatment ...
Chin, Hang Gyeong, Fitzgerald, Kevin, George, Kelly, Hansen, Ulla, Pedamallu, Chandra Sekhar, Roberto, Mark P., Schaus, Scott, Shah, Jagesh, Shin, Hyunjin, Stoiber, Patrick, Willoughby, Jennifer L. S.   +10 more
core   +1 more source

High‐throughput screening identifies a previously undescribed checkpoint controlling mitotic progression in response to DNA damage

The FEBS Journal, EarlyView.
DNA damage can cause mitotic delay to allow DNA repair to occur. However, the mechanism underlying this is unclear. Here, we show that in response to cells entering mitosis with DNA damage, SOD1 restrains PP2a activity via oxidation of cysteine residues at the active site. This leads to a reduction in PP2a activity at the mitotic kinetochore, resulting
Nan Li, Rachel Gatenby, Thomas Walne, Caroline Daye, Steven Watson, Priya Lata, Stephen Brown, Ruth Thompson   +7 more
wiley   +1 more source

Identification of a Proliferation Gene Cluster Associated with HPV E6/E7 Expression Level and Viral DNA Load in Invasive Cervical Carcinoma

, 2005
Specific HPV DNA sequences are associated with more than 90% of invasive carcinomas of the uterine cervix. Viral E6 and E7 oncogenes are key mediators in cell transformation by disrupting TP53 and RB pathways. To investigate molecular mechanisms involved
Anne de La Rochefordière, Christophe Rosty, Dafna Tsafrir, Eytan Domany, F Ferlay, François Radvanyi, Ilan Tsafrir, Jean Paul Thiery, Jérôme Couturier, Martine Peter, Michal Sheffer, Nicolas Stransky, Patricia de Crémoux, Rémy Salmon, Thierry Dorval, Xavier Sastre-Garau   +15 more
core   +1 more source