Co-silencing of human Bub3 and dynein highlights an antagonistic relationship in regulating kinetochore-microtubule attachments [PDF]
, 2015 We previously reported that the spindle assembly checkpoint protein Bub3 is involved in regulating kinetochore-microtubule (KT-MT) attachments. Also, Bub3 was reported to interact with the microtubule motor protein dynein.
Barisic +27 more
core +1 more source
Where, When, and How? Integrating Spatiotemporal Cues in Cell Division
BioEssays, Volume 48, Issue 1, January 2026.Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo +3 more
wiley +1 more source
Dual inhibition of Cdc20 by the spindle checkpoint
Journal of Biomedical Science, 2007 The metaphase-to-anaphase transition is triggered by the Anaphase-Promoting Complex (APC), an E3 ubiquitin ligase that targets proteins for degradation, leading to sister chromatid separation and mitotic exit. The function of APC is controlled by the spindle checkpoint that delays anaphase onset in the presence of any chromosome that has not ...
openaire +2 more sources
BioEssays, Volume 48, Issue 1, January 2026.Mathematical model of a perfused cylindrical tumor predicts venous‐end extracellular [O2], pH, [CO2], and [HCO3−] in the case of either fermentative or respiratory metabolism, illustrating the relationship between hypoxia and acidosis and the chemical composition of acidosis in the tumor microenvironment. ABSTRACT In well‐perfused tissues, interstitial
Alzbeta Hulikova, Pawel Swietach
wiley +1 more source
Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling
Communications BiologyAccurate mitosis is coordinated by the spindle assembly checkpoint (SAC) through the mitotic checkpoint complex (MCC), which inhibits the anaphase-promoting complex or cyclosome (APC/C).
Yuqing Zhang +10 more
doaj +1 more source
Insights into APC/C: From cellular function to diseases and therapeutics [PDF]
, 2016 Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as cell division, differentiation, genome ...
He, M, Shah, AA, Wan, Y, Zhou, Z
core +2 more sources
Precocious activation of APC/C-Cdh1 at pre-anaphase causes genome instability [PDF]
, 2008 Faithful chromosome segregation and thereby accurate gene transmission are crucial for all organisms. Until proper attachment of the mitotic spindle to the kinetochore is established, the ubiquitin ligase (E3) Cdc20-activated APC/C (anaphase promoting ...
Asuka Suzuki +6 more
core +1 more source
Extending boolean regulatory network models with answer set programming [PDF]
, 2010 Because of their simplicity, boolean networks are a popular formalism to model gene regulatory networks. However, they have their limitations, including their inability to formally and unambiguously define network behaviour, and their lack of the ...
Fayruzov, Timur +4 more
core +2 more sources
Knockdown of CDC20 Promotes Adipogenesis of Bone Marrow-derived Stem Cells [PDF]
, 2021 Yangge Du +3 more
openalex +1 more source
Enhancing Bone Regeneration through CDC20‐Loaded ZIF‐8 Nanoparticles Wrapped in Erythrocyte Membranes with Targeting Aptamer [PDF]
, 2023 Yangge Du +7 more
openalex +1 more source