Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]
, 2014 Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Cascales, H.S. +4 more
core +4 more sources
Enhancing Bone Regeneration through CDC20‐Loaded ZIF‐8 Nanoparticles Wrapped in Erythrocyte Membranes with Targeting Aptamer [PDF]
, 2023 Yangge Du +7 more
openalex +1 more source
Arthritis &Rheumatology, Volume 77, Issue 12, Page 1713-1725, December 2025.Objective This study investigates the role of senescent epidermal basal cells in cutaneous lupus erythematosus (CLE) pathogenesis using skin samples from patients with CLE and a mouse model of systemic lupus erythematosus (SLE). Methods Cellular senescence profiling used datasets from the NCBI GEO database and Accelerating Medicines Partnership (AMP ...
Sena Yamamoto +13 more
wiley +1 more source
Dual inhibition of Cdc20 by the spindle checkpoint
Journal of Biomedical Science, 2007 The metaphase-to-anaphase transition is triggered by the Anaphase-Promoting Complex (APC), an E3 ubiquitin ligase that targets proteins for degradation, leading to sister chromatid separation and mitotic exit. The function of APC is controlled by the spindle checkpoint that delays anaphase onset in the presence of any chromosome that has not ...
openaire +2 more sources
Cyclin dependent kinase 1-dependent activation of APC/C ubiquitin ligase [PDF]
, 2016 Error-free genome duplication and segregation are ensured through the timely activation of ubiquitylation enzymes. The anaphase-promoting complex/cyclosome (APC/C), a multisubunit E3 ubiquitin ligase, is regulated by phosphorylation.
Fujimitsu, K, Grimaldi, M, Yamano, H
core +1 more source
Role of Tryptophan Metabolism in Cancer
Cancer Innovation, Volume 4, Issue 6, December 2025.This review systematically summarizes the functions and related mechanisms of tryptophan metabolism in various tumor types. It presents the latest progress in this field in a comprehensive manner and combines this with clinical practice to offer a new perspective on tumor treatment.
Zhehao Cui +5 more
wiley +1 more source
Functional analysis of Cdc20 reveals a critical role of CRY box in mitotic checkpoint signaling
Communications BiologyAccurate mitosis is coordinated by the spindle assembly checkpoint (SAC) through the mitotic checkpoint complex (MCC), which inhibits the anaphase-promoting complex or cyclosome (APC/C).
Yuqing Zhang +10 more
doaj +1 more source
Precision Modeling of Alzheimer’s Disease via Integrative Pathway Activity Analysis across Human Brains and Cellular Models for Discovering Translatable Therapeutic Targets [PDF]
Alzheimers DementAbstract Background Successful Alzheimer’s disease (AD) interventions in preclinical models often fail in human trials. While preclinical models offer insights into AD mechanisms, there is no systematic approach to verify whether preclinical target mechanisms retain therapeutic relevance in humans.
Yeganeh P +6 more
europepmc +2 more sources
Efficient Parallel Statistical Model Checking of Biochemical Networks [PDF]
, 2009 We consider the problem of verifying stochastic models of biochemical networks against behavioral properties expressed in temporal logic terms. Exact probabilistic verification approaches such as, for example, CSL/PCTL model checking, are undermined by a
A. Pnueli +38 more
core +2 more sources
CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy
Theranostics, 2018 Rationale: Sustained cardiac hypertrophy often leads to heart failure (HF). Understanding the regulation of cardiomyocyte growth is crucial for the treatment of adverse ventricular remodeling and HF. Cell division cycle 20 (CDC20) is an anaphase-promoting complex activator that is essential for cell division and tumorigenesis, but the role of CDC20 in ...
Xie, Yun-Peng +7 more
openaire +2 more sources