Results 121 to 130 of about 20,500 (223)

Knockouts, Robustness and Cell Cycles

, 2010
The response to a knockout of a node is a characteristic feature of a networked dynamical system. Knockout resilience in the dynamics of the remaining nodes is a sign of robustness.
A. Wagner, Eckehard Olbrich, Gunnar Boldhaus, Johannes Rauh, Konstantin Klemm, N. Ay, Nils Bertschinger, R. A. Fisher   +7 more
core   +1 more source

Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Relapsed and refractory multiple myeloma remains a major clinical challenge. This study shows that FOXM1 contributes to resistance against BH3 mimetics in multiple myeloma cells. The FOXM1 inhibitor NB73 enhances the effectiveness of BH3 mimetics by reducing FOXM1 expression and suppressing the MYC pathway.
Zhi Wen, Yidan Wang, Kathryn C. Fox, Adam M. Bissonnette, Luke F. Moat, Terrie E. Kitchner, Kelsey Springstroh, Sung Hoon Kim, Dagna S. Sheerar, Patcharon Tanawattanacharoen, Chady A. Leon, Seth O. Fagbemi, John A. Katzenellenbogen, Scott J. Hebbring, Benita S. Katzenellenbogen, Siegfried Janz, Adedayo A. Onitilo   +16 more
wiley   +1 more source

CDC20 Knockdown and Acidic Microenvironment Collaboratively Promote Tumorigenesis through Inhibiting Autophagy and Apoptosis

Molecular Therapy: Oncolytics, 2020
The reconstitution of the tumorigenesis process would shed light on the tumor development study and further drug selection strategies. To construct a tumorigenesis model and explore potential mechanism is of great importance.
Qingying Gu, Fang Li, Shengfang Ge, Feifei Zhang, Renbing Jia, Xianqun Fan   +5 more
doaj   +1 more source

Inferring Biologically Relevant Models: Nested Canalyzing Functions [PDF]

, 2010
Inferring dynamic biochemical networks is one of the main challenges in systems biology. Given experimental data, the objective is to identify the rules of interaction among the different entities of the network.
Hinkelmann, Franziska, Jarrah, Abdul Salam   +1 more
core   +3 more sources

Cdc20 protects cells from Ara-c-induced apoptosis in AML via targeting  autophagy [PDF]

, 2021
Shumin Ding, Jin-Yao Kan, Yan Wang, Siyuan Cui, Jingyi Wang, Zonghong Li, Teng Wang, Daoxin Ma, Ruirong Xu   +8 more
openalex   +1 more source

Efficient Parallel Statistical Model Checking of Biochemical Networks [PDF]

, 2009
We consider the problem of verifying stochastic models of biochemical networks against behavioral properties expressed in temporal logic terms. Exact probabilistic verification approaches such as, for example, CSL/PCTL model checking, are undermined by a
A. Pnueli, A. S. Miner, Adnan Aziz, B. Novak, Christel Baier, D. Donaldson, R., D.O. Morgan, D.O. Morgan, D.T. Gillespie, D.T. Gillespie, Davide Prandi, E. B. Wilson, Edmund M Clarke, Edmund M. Clarke, Fran¸ cois Fages, H. A. Hansson, H. Kitano, H. Li, H. Younes, J.-P. Katoen, Jaco van de Pol, Jiv r'ı Barnat, L. Dematte, Laurence Calzone, Lawrence D. Brown, Lawrence D. Brown, Lubos Brim, M. Kwiatkowska, M. Kwiatkowska, M. Scarpa, Michele Forlin, P. Ballarini, P. Ballarini, Paolo Ballarini, T. Tian, Thomas Hérault, Tommaso Mazza, Walter W. Piegorsch, William J. Stewart   +38 more
core   +2 more sources

Dendrite Development Regulated by the Schizophrenia-Associated Gene FEZ1 Involves the Ubiquitin Proteasome System

Cell Reports, 2014
Summary: Downregulation of the schizophrenia-associated gene DISC1 and its interacting protein FEZ1 positively regulates dendrite growth in young neurons.
Yasuhito Watanabe, Konstantin Khodosevich, Hannah Monyer   +2 more
doaj   +1 more source

Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A [PDF]

, 2008
Rob M.F. Wolthuis, Lori Clay-Farrace, Wouter van Zon, Mona Yekezare, Lars Koop, Janneke Ogink, René H. Medema, Jonathon Pines   +7 more
openalex   +1 more source

The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation

Nature Communications, 2016
The mitotic checkpoint complex (MCC) inhibits the anaphase-promoting complex (APC/C) bound to Cdc20 in response to spindle defects. Here, the authors show that Bub1-Plk1-mediated phosphorylation of Cdc20 constitutes a parallel, non-redundant APC/C ...
Luying Jia, Bing Li, Hongtao Yu
doaj   +1 more source

Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer [PDF]

, 2021
Owen J. Chen, Ester Castellsagué, Mohamed Moustafa-Kamal, Javad Nadaf, Bárbara Rivera, Somayyeh Fahiminiya, Yilin Wang, Isabelle Gamache, Caterina Pacifico, Lai Jiang, Jian Carrot‐Zhang, Leora Witkowski, Albert M. Berghuis, Stefan Schoenberger, Dominik T. Schneider, Susanne Bens, Reiner Siebert, Colin J.R. Stewart, Ziguo Zhang, William Chong Hang Chao, Celia M.T. Greenwood, David Barford, Marc Tischkowitz, Jacek Majewski, William D. Foulkes, Jose G. Teodoro   +25 more
openalex   +1 more source