Results 121 to 130 of about 20,775 (267)
Bub1, a Gatekeeper for Cdc20-Dependent Mitotic Exit [PDF]
Developmental Cell, 2004 The mitotic spindle assembly checkpoint arrests cells at metaphase by suppressing Cdc20, a protein required to trigger ubiquitination and consequent degradation of cyclin B. New evidence from Tang et al. appearing in the November 5th issue of Molecular Cell finds that one of the checkpoint proteins, Bub1, specifically phosphorylates Cdc20 to suppress ...
openaire +2 more sources
Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control
Computational and Structural Biotechnology Journal, 2015 The spindle checkpoint assembly (SAC) ensures genome fidelity by temporarily delaying anaphase onset, until all chromosomes are properly attached to the mitotic spindle.
Bashar Ibrahim
doaj +1 more source
Mitotic Cdc6 Stabilizes Anaphase-Promoting Complex Substrates by a Partially Cdc28-Independent Mechanism, and This Stabilization Is Suppressed by Deletion of Cdc55 [PDF]
, 2006 Ectopic expression of Cdc6p results in mitotic delay, and this has been attributed to Cdc6p-mediated inhibition of Cdc28 protein kinase and failure to activate the anaphase-promoting complex (APC).
Boronat, Susanna, Campbell, Judith L.
core +3 more sources
Plant Biotechnology Journal, EarlyView.ABSTRACT Solanum tuberosum L. (potato) is a key food crop, with its tubers serving as an important food source worldwide. Tuber development is a tightly regulated process involving the transition of a hooked stolon (a modified stem) to a tuber following the perception of mobile signals within the stolon tip. While genes like FLOWERING LOCUS T homologue
Dionne Martin +2 more
wiley +1 more source
Cdc20: A Potential Novel Therapeutic Target for Cancer Treatment [PDF]
Current Pharmaceutical Design, 2013 The Anaphase Promoting Complex (APC) has been characterized to play pivotal roles in regulating the timely cell cycle progression by forming two functionally distinct E3 ubiquitin ligase sub-complexes, APC(Cdc20) and APC(Cdh1). Interestingly, recent studies have shown that Cdh1 is functioning as a tumor suppressor whereas Cdc20 may function as an ...
Zhiwei, Wang +6 more
openaire +2 more sources
Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy. [PDF]
PLoS Pathogens, 2018 Shugoshin-1 (Sgo1) protects the integrity of the centromeres, and H2A phosphorylation is critical for this process. The mitotic checkpoint kinase Bub1, phosphorylates H2A and ensures fidelity of chromosome segregation and chromosome number.
Fengchao Lang +5 more
doaj +1 more source
Photochemistry and Photobiology, EarlyView.Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye +5 more
wiley +1 more source
Edge usage, motifs and regulatory logic for cell cycling genetic networks
, 2013 The cell cycle is a tightly controlled process, yet its underlying genetic network shows marked differences across species. Which of the associated structural features follow solely from the ability to impose the appropriate gene expression patterns?
Krzywicki, A. +2 more
core +3 more sources
The role of the anaphase-promoting complex/cyclosome in plant growth [PDF]
, 2015 The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that plays a major role in the progression of the eukaryotic cell cycle.
de Freitas Lima, Marcelo +3 more
core +2 more sources
Where, When, and How? Integrating Spatiotemporal Cues in Cell Division
BioEssays, Volume 48, Issue 1, January 2026.Accurate chromosome segregation during mitosis depends on the spatial and temporal regulation of spindle assembly, kinetochore‐microtubule attachment, and checkpoint signaling. Here, we highlight how mitotic chromosomes can serve as dynamic hubs that integrate molecular cues to coordinate spindle organization and timing, ensuring faithful genome ...
Luca Cirillo +3 more
wiley +1 more source