Results 131 to 140 of about 18,904 (232)

Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A [PDF]

open access: bronze, 2008
Rob M.F. Wolthuis   +7 more
openalex   +1 more source

Dendrite Development Regulated by the Schizophrenia-Associated Gene FEZ1 Involves the Ubiquitin Proteasome System

open access: yesCell Reports, 2014
Summary: Downregulation of the schizophrenia-associated gene DISC1 and its interacting protein FEZ1 positively regulates dendrite growth in young neurons.
Yasuhito Watanabe   +2 more
doaj   +1 more source

Modelling Cell Cycle using Different Levels of Representation

open access: yes, 2009
Understanding the behaviour of biological systems requires a complex setting of in vitro and in vivo experiments, which attracts high costs in terms of time and resources.
Antonio Cerone   +3 more
core   +2 more sources

Selected Ideal Natural Ligand Against TNBC by Inhibiting CDC20, Using Bioinformatics and Molecular Biology [PDF]

open access: gold, 2021
Naimeng Liu   +6 more
openalex   +1 more source

Precocious activation of APC/C-Cdh1 at pre-anaphase causes genome instability [PDF]

open access: yes, 2008
Faithful chromosome segregation and thereby accurate gene transmission are crucial for all organisms. Until proper attachment of the mitotic spindle to the kinetochore is established, the ubiquitin ligase (E3) Cdc20-activated APC/C (anaphase promoting ...
Asuka Suzuki   +6 more
core   +1 more source

Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer [PDF]

open access: gold, 2021
Owen J. Chen   +25 more
openalex   +1 more source

The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation

open access: yesNature Communications, 2016
The mitotic checkpoint complex (MCC) inhibits the anaphase-promoting complex (APC/C) bound to Cdc20 in response to spindle defects. Here, the authors show that Bub1-Plk1-mediated phosphorylation of Cdc20 constitutes a parallel, non-redundant APC/C ...
Luying Jia, Bing Li, Hongtao Yu
doaj   +1 more source

Cyclin destruction in mitosis: a crucial task of Cdc20

open access: yesFEBS Letters, 2002
Proteolytic destruction of cyclins is a fundamental process for cell division. At the end of mitosis, degradation of mitotic cyclins results in the inactivation of cyclin‐dependent kinases. Cyclin proteolysis is triggered by the anaphase‐promoting complex/cyclosome (APC/C), a multi‐subunit complex which contains ubiquitin ligase activity.
openaire   +2 more sources

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