Results 131 to 140 of about 20,775 (267)
LSF small molecule inhibitors phenocopy LSF-targeted siRNAs causing mitotic defects and senescence in cancer cells [PDF]
, 2019 The oncogene LSF has been proposed as a novel target with therapeutic potential for multiple cancers. LSF overexpression correlates with poor prognosis for both liver and colorectal cancers, for which there are currently limited therapeutic treatment ...
Chin, Hang Gyeong +10 more
core +1 more source
BioEssays, Volume 48, Issue 1, January 2026.Mathematical model of a perfused cylindrical tumor predicts venous‐end extracellular [O2], pH, [CO2], and [HCO3−] in the case of either fermentative or respiratory metabolism, illustrating the relationship between hypoxia and acidosis and the chemical composition of acidosis in the tumor microenvironment. ABSTRACT In well‐perfused tissues, interstitial
Alzbeta Hulikova, Pawel Swietach
wiley +1 more source
Cdc20: At the Crossroads between Chromosome Segregation and Mitotic Exit [PDF]
Trends in Biochemical Sciences, 2017 Cell-division cycle protein 20 homologue (Cdc20) has important functions in chromosome segregation and mitotic exit. Cdc20 is the target of the spindle assembly checkpoint (SAC) and a key cofactor of the anaphase-promoting complex or cyclosome (APC/C) E3 ubiquitin ligase, thus regulating APC/C ubiquitin activity on specific substrates for their ...
Kapanidou, Maria +2 more
openaire +3 more sources
PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B [PDF]
, 2022 Zhaotao Wang +11 more
openalex +1 more source
CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation
Advanced Science, Volume 12, Issue 47, December 18, 2025.Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao +18 more
wiley +1 more source
Insights into APC/C: From cellular function to diseases and therapeutics [PDF]
, 2016 Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as cell division, differentiation, genome ...
He, M, Shah, AA, Wan, Y, Zhou, Z
core +2 more sources
Role of Tryptophan Metabolism in Cancer
Cancer Innovation, Volume 4, Issue 6, December 2025.This review systematically summarizes the functions and related mechanisms of tryptophan metabolism in various tumor types. It presents the latest progress in this field in a comprehensive manner and combines this with clinical practice to offer a new perspective on tumor treatment.
Zhehao Cui +5 more
wiley +1 more source
A little Cdc20 goes a long way [PDF]
Journal of Cell Biology, 2010 Hypomorphic mice reveal new details of Cdc20 and cyclin B1's mitotic activities.
openaire +1 more source
The Interplay among PINK1/PARKIN/Dj-1 Network during Mitochondrial Quality Control in Cancer Biology: Protein Interaction Analysis [PDF]
, 2018 PARKIN (E3 ubiquitin ligase PARK2), PINK1 (PTEN induced kinase 1) and DJ-1 (PARK7) are proteins involved in autosomal recessive parkinsonism, and carcinogenic processes.
Lucas, Millikin, Narendra, Santel, Zhang
core +2 more sources
Alternative CDC20 translational isoforms tune mitotic arrest duration
Nature, 2023 Mary-Jane Tsang, I. Cheeseman
semanticscholar +1 more source