Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A [PDF]
, 2008 Rob M.F. Wolthuis +7 more
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Cell Reports, 2014 Summary: Downregulation of the schizophrenia-associated gene DISC1 and its interacting protein FEZ1 positively regulates dendrite growth in young neurons.
Yasuhito Watanabe +2 more
doaj +1 more source
Modelling Cell Cycle using Different Levels of Representation
, 2009 Understanding the behaviour of biological systems requires a complex setting of in vitro and in vivo experiments, which attracts high costs in terms of time and resources.
Antonio Cerone +3 more
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Selected Ideal Natural Ligand Against TNBC by Inhibiting CDC20, Using Bioinformatics and Molecular Biology [PDF]
, 2021 Naimeng Liu +6 more
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Precocious activation of APC/C-Cdh1 at pre-anaphase causes genome instability [PDF]
, 2008 Faithful chromosome segregation and thereby accurate gene transmission are crucial for all organisms. Until proper attachment of the mitotic spindle to the kinetochore is established, the ubiquitin ligase (E3) Cdc20-activated APC/C (anaphase promoting ...
Asuka Suzuki +6 more
core +1 more source
Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer [PDF]
, 2021 Owen J. Chen +25 more
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The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
Nature Communications, 2016 The mitotic checkpoint complex (MCC) inhibits the anaphase-promoting complex (APC/C) bound to Cdc20 in response to spindle defects. Here, the authors show that Bub1-Plk1-mediated phosphorylation of Cdc20 constitutes a parallel, non-redundant APC/C ...
Luying Jia, Bing Li, Hongtao Yu
doaj +1 more source
Cyclin destruction in mitosis: a crucial task of Cdc20
FEBS Letters, 2002 Proteolytic destruction of cyclins is a fundamental process for cell division. At the end of mitosis, degradation of mitotic cyclins results in the inactivation of cyclin‐dependent kinases. Cyclin proteolysis is triggered by the anaphase‐promoting complex/cyclosome (APC/C), a multi‐subunit complex which contains ubiquitin ligase activity.
openaire +2 more sources
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation [PDF]
, 1998 Guowei Fang +2 more
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Supplementary Figure S2 from Hyperphosphorylation of CDH1 in Glioblastoma Cancer Stem Cells Attenuates APC/C<sup>CDH1</sup> Activity and Pharmacologic Inhibition of APC/C<sup>CDH1/CDC20</sup> Compromises Viability [PDF]
, 2023 Kuntal De +7 more
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