Results 141 to 150 of about 20,775 (267)
E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy
MedComm, Volume 6, Issue 12, December 2025.E3 ligases function as critical regulators of cellular protein degradation, and their dysregulation is a core pathogenic mechanism in a wide array of human diseases, including cancer, cardiovascular conditions, neurodegenerative disorders, and autoimmune diseases.
Haochen Wang +6 more
wiley +1 more source
Knockouts, Robustness and Cell Cycles
, 2010 The response to a knockout of a node is a characteristic feature of a networked dynamical system. Knockout resilience in the dynamics of the remaining nodes is a sign of robustness.
A. Wagner +7 more
core +1 more source
Cdc20 protects cells from Ara-c-induced apoptosis in AML via targeting autophagy [PDF]
, 2021 Shumin Ding +8 more
openalex +1 more source
Smart Medicine, Volume 4, Issue 4, December 2025.We identified four distinct NK cell subtypes within the melanoma microenvironment and elucidated their biological roles. Crucially, spatial analysis demonstrated that a specific subtype (NK cluster 01) exhibits a mutual repulsion with melanoma cells, suggesting an active evasion mechanism. These insights highlight specific NK cell subtypes as promising
Zhicheng Hu +9 more
wiley +1 more source
Cyclin dependent kinase 1-dependent activation of APC/C ubiquitin ligase [PDF]
, 2016 Error-free genome duplication and segregation are ensured through the timely activation of ubiquitylation enzymes. The anaphase-promoting complex/cyclosome (APC/C), a multisubunit E3 ubiquitin ligase, is regulated by phosphorylation.
Fujimitsu, K, Grimaldi, M, Yamano, H
core +1 more source
The FEBS Journal, Volume 292, Issue 24, Page 6516-6532, December 2025.DNA damage can slow or delay the cell cycle to allow for DNA repair to occur. However, the mechanism underlying this is unclear. Here, we show that in response to cells entering mitosis with damaged DNA, SOD1 restrains the activity of the phosphatase PP2a activity via oxidation of cysteine residues at PP2a's active site.
Nan Li +7 more
wiley +1 more source
Cdc20: A WD40 Activator for a Cell Cycle Degradation Machine [PDF]
Molecular Cell, 2007 Cdc20 is an essential cell-cycle regulator required for the completion of mitosis in organisms from yeast to man and contains at its C terminus a WD40 repeat domain that mediates protein-protein interactions. In mitosis, Cdc20 binds to and activates the ubiquitin ligase activity of a large molecular machine called the anaphase-promoting complex ...
openaire +2 more sources
Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]
, 2014 Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Cascales, H.S. +4 more
core +4 more sources
Advanced Science, Volume 12, Issue 42, November 13, 2025.Clathrin Light Chain B (CLTB) drives hepatocellular carcinoma progression through dual pathways: intracellularly, it activates the NF‐κB–PCLAF axis to enhance small extracellular vesicle (sEV) uptake and tumor proliferation; extracellularly, CLTB‐enriched sEVs bind SH3KBP1 to inhibit its degradation, inducing angiogenesis and vascular leakage ...
Xiaoke Sun +7 more
wiley +1 more source
Cyclin destruction in mitosis: a crucial task of Cdc20
FEBS Letters, 2002 Proteolytic destruction of cyclins is a fundamental process for cell division. At the end of mitosis, degradation of mitotic cyclins results in the inactivation of cyclin‐dependent kinases. Cyclin proteolysis is triggered by the anaphase‐promoting complex/cyclosome (APC/C), a multi‐subunit complex which contains ubiquitin ligase activity.
openaire +2 more sources