Results 151 to 160 of about 20,775 (267)

Co-silencing of human Bub3 and dynein highlights an antagonistic relationship in regulating kinetochore-microtubule attachments [PDF]

, 2015
We previously reported that the spindle assembly checkpoint protein Bub3 is involved in regulating kinetochore-microtubule (KT-MT) attachments. Also, Bub3 was reported to interact with the microtubule motor protein dynein.
Barisic, Efimov, Gassmann, Gassmann, Gassmann, Hassan Bousbaa, Kops, Lo, Logarinho, Logarinho, Maia, Maresca, Musacchio, Patrícia M.A. Silva, Pfarr, Reis, Rieder, Sharp, Silva, Silva, Stehman, Steuer, Uchida, Vaisberg, Varma, Waters, Yang, Álvaro A. Tavares   +27 more
core   +1 more source

Differential expression of CDC20 in cancer of the cervix.

, 2023
Almost all cervical cancers are caused by infection with high-risk human papillomaviruses (HPVs) (1-3); the transcriptional features that distinguish the gene expression programs of HPV-induced cancers from that of cancers resulting from non-viral abrogation of tumor suppression remain incompletely defined. We mined published microarray datasets (4, 5)
openaire   +1 more source

Cdc20 Is Critical for Meiosis I and Fertility of Female Mice

PLoS Genetics, 2010
Chromosome missegregation in germ cells is an important cause of unexplained infertility, miscarriages, and congenital birth defects in humans. However, the molecular defects that lead to production of aneuploid gametes are largely unknown. Cdc20, the activating subunit of the anaphase-promoting complex/cyclosome (APC/C), initiates sister-chromatid ...
Jin, F., Hamada, M., Malureanu, L., Jeganathan, K.B., Zhou, W., Morbeck, D.E., Deursen, J.M.A. van   +6 more
openaire   +6 more sources

Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A [PDF]

, 2008
Rob M.F. Wolthuis, Lori Clay-Farrace, Wouter van Zon, Mona Yekezare, Lars Koop, Janneke Ogink, René H. Medema, Jonathon Pines   +7 more
openalex   +1 more source

Selected Ideal Natural Ligand Against TNBC by Inhibiting CDC20, Using Bioinformatics and Molecular Biology [PDF]

, 2021
Naimeng Liu, Xinhui Wang, Xiaye Lv, Duo Li, Haoqun Xie, Zhen Guo, Dong Song   +6 more
openalex   +1 more source

Dendrite Development Regulated by the Schizophrenia-Associated Gene FEZ1 Involves the Ubiquitin Proteasome System

Cell Reports, 2014
Summary: Downregulation of the schizophrenia-associated gene DISC1 and its interacting protein FEZ1 positively regulates dendrite growth in young neurons.
Yasuhito Watanabe, Konstantin Khodosevich, Hannah Monyer   +2 more
doaj   +1 more source

Modelling Cell Cycle using Different Levels of Representation

, 2009
Understanding the behaviour of biological systems requires a complex setting of in vitro and in vivo experiments, which attracts high costs in terms of time and resources.
Antonio Cerone, Gabriel Ciobanu, Rafael V. Carvalho, Thomas Anung Basuki   +3 more
core   +2 more sources

Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer [PDF]

, 2021
Owen J. Chen, Ester Castellsagué, Mohamed Moustafa-Kamal, Javad Nadaf, Bárbara Rivera, Somayyeh Fahiminiya, Yilin Wang, Isabelle Gamache, Caterina Pacifico, Lai Jiang, Jian Carrot‐Zhang, Leora Witkowski, Albert M. Berghuis, Stefan Schoenberger, Dominik T. Schneider, Susanne Bens, Reiner Siebert, Colin J.R. Stewart, Ziguo Zhang, William Chong Hang Chao, Celia M.T. Greenwood, David Barford, Marc Tischkowitz, Jacek Majewski, William D. Foulkes, Jose G. Teodoro   +25 more
openalex   +1 more source

Mitotic Regulation of the APC Activator Proteins CDC20 and CDH1

Molecular Biology of the Cell, 2000
The ordered activation of the ubiquitin protein ligase anaphase-promoting complex (APC) or cyclosome by CDC20 in metaphase and by CDH1 in telophase is essential for anaphase and for exit from mitosis, respectively. Here, we show that CDC20 can only bind to and activate the mitotically phosphorylated form of theXenopus and the human APC in vitro.
E R, Kramer, N, Scheuringer, A V, Podtelejnikov, M, Mann, J M, Peters   +4 more
openaire   +3 more sources

Precocious activation of APC/C-Cdh1 at pre-anaphase causes genome instability [PDF]

, 2008
Faithful chromosome segregation and thereby accurate gene transmission are crucial for all organisms. Until proper attachment of the mitotic spindle to the kinetochore is established, the ubiquitin ligase (E3) Cdc20-activated APC/C (anaphase promoting ...
Asuka Suzuki, Ayumu Yamamoto, Kazuhiro Toda, Masahiro Uritani, Masaru Ueno, Takanori Ohyoshi, Takashi Ushimaru   +6 more
core   +1 more source