Results 11 to 20 of about 18,977 (237)
High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors [PDF]
EMBO ReportsSpindle assembly checkpoint (SAC) inhibitors are a recently developed class of drugs, which perturb chromosome segregation during cell division, induce chromosomal instability (CIN), and eventually lead to cell death.
Siqi Zheng +16 more
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Bub1, a Gatekeeper for Cdc20-Dependent Mitotic Exit [PDF]
Developmental Cell, 2004 The mitotic spindle assembly checkpoint arrests cells at metaphase by suppressing Cdc20, a protein required to trigger ubiquitination and consequent degradation of cyclin B. New evidence from Tang et al. appearing in the November 5th issue of Molecular Cell finds that one of the checkpoint proteins, Bub1, specifically phosphorylates Cdc20 to suppress ...
Robert L. Margolis
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Non-Canonical HIPPO-MST1/2 Promotes Hyper-Proliferation of Pulmonary Vascular Cells through CDC20. [PDF]
Am J Respir Cell Mol BiolDey T +13 more
europepmc +3 more sources
PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B [PDF]
Oncogene, 2022 AbstractPRMT6, a type I arginine methyltransferase, di-methylates the arginine residues of both histones and non-histones asymmetrically. Increasing evidence indicates that PRMT6 plays a tumor mediator involved in human malignancies. Here, we aim to uncover the essential role and underlying mechanisms of PRMT6 in promoting glioblastoma (GBM ...
Zhaotao Wang +11 more
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Frontiers in Oncology, 2021 The landscape of CDC20 gene expression and its biological impacts across different types of cancers remains largely unknown. Here, a pan-cancer analysis was performed to analyze the role of Cdc20 in various human cancers.
Fei Wu +8 more
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Cdc20: A Potential Novel Therapeutic Target for Cancer Treatment [PDF]
Current Pharmaceutical Design, 2013 The Anaphase Promoting Complex (APC) has been characterized to play pivotal roles in regulating the timely cell cycle progression by forming two functionally distinct E3 ubiquitin ligase sub-complexes, APC(Cdc20) and APC(Cdh1). Interestingly, recent studies have shown that Cdh1 is functioning as a tumor suppressor whereas Cdc20 may function as an ...
Zhiwei Wang +6 more
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Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]
, 2014 The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
Corbishley, Stephen +5 more
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Correction: CDC20 protects the heart from doxorubicin-induced cardiotoxicity by modulating CCDC69 degradation. [PDF]
Cell Mol Biol LettFeng Z +5 more
europepmc +3 more sources
Kaohsiung Journal of Medical Sciences, 2022 Cell division cycle 20 (CDC20) and microRNAs (miRNAs) are differentially expressed in non‐small cell lung cancer (NSCLC). The current study aimed to investigate the role of miR‐1321 and miR‐7515 regulation in CDC20 during NSCLC development.
Hao Hu +7 more
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Knockdown of CDC20 promotes adipogenesis of bone marrow-derived stem cells by modulating β-catenin
Stem Cell Research & Therapy, 2022 Background Bone is a rigid organ that provides physical protection and support to vital organs of the body. Bone loss disorders are commonly associated with increased bone marrow adipose tissue.
Yangge Du +3 more
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