Results 11 to 20 of about 20,775 (267)

Regulated degradation of the APC coactivator Cdc20 [PDF]

Cell Division, 2010
Background Cdc20 is a highly conserved activator of the anaphase-promoting complex (APC), promoting cell-cycle-regulated ubiquitination and proteolysis of a number of critical cell-cycle-regulatory targets including securin and mitotic cyclins. APC-Cdc20
Robbins Jonathan A, Cross Frederick R
doaj   +3 more sources

The Oncogenic Role of APC/C Activator Protein Cdc20 by an Integrated Pan-Cancer Analysis in Human Tumors

Frontiers in Oncology, 2021
The landscape of CDC20 gene expression and its biological impacts across different types of cancers remains largely unknown. Here, a pan-cancer analysis was performed to analyze the role of Cdc20 in various human cancers.
Fei Wu, Fei Wu, Yang Sun, Jie Chen, Hongyun Li, Kang Yao, Yongjun Liu, Qingyong Liu, Jiaju Lu   +8 more
doaj   +2 more sources

A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.

PLoS Pathogens, 2012
Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC/C ...
David S Guttery, David J P Ferguson, Benoit Poulin, Zhengyao Xu, Ursula Straschil, Onny Klop, Lev Solyakov, Sara M Sandrini, Declan Brady, Conrad A Nieduszynski, Chris J Janse, Anthony A Holder, Andrew B Tobin, Rita Tewari   +13 more
doaj   +2 more sources

Functional analysis of recurrent CDC20 promoter variants in human melanoma

Communications Biology, 2023
Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks.
Paula M. Godoy, Abimbola Oyedeji, Jacqueline L. Mudd, Vasilios A. Morikis, Anna P. Zarov, Gregory D. Longmore, Ryan C. Fields, Charles K. Kaufman   +7 more
doaj   +2 more sources

A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells [PDF]

Cell Reports, 2015
Glioblastoma harbors a dynamic subpopulation of glioblastoma stem-like cells (GSCs) that can propagate tumors in vivo and is resistant to standard chemoradiation.
Diane D. Mao, Amit D. Gujar, Tatenda Mahlokozera, Ishita Chen, Yanchun Pan, Jingqin Luo, Taylor Brost, Elizabeth A. Thompson, Alice Turski, Eric C. Leuthardt, Gavin P. Dunn, Michael R. Chicoine, Keith M. Rich, Joshua L. Dowling, Gregory J. Zipfel, Ralph G. Dacey, Samuel Achilefu, David D. Tran, Hiroko Yano, Albert H. Kim   +19 more
doaj   +2 more sources

Juxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly

Nature Communications, 2022
Formation of the mitotic checkpoint complex (MCC) is catalysed by a phosphorylation-dependent scaffold. This work provides structural details of how a tripartite Mad1:Bub1:Cdc20 complex presents Cdc20 to Mad2, triggering open-to-closed conversion of Mad2
Elyse S. Fischer, Conny W. H. Yu, Johannes F. Hevler, Stephen H. McLaughlin, Sarah L. Maslen, Albert J. R. Heck, Stefan M. V. Freund, David Barford   +7 more
doaj   +2 more sources

Cell division cycle 20 (CDC20) drives prostate cancer progression via stabilization of β-catenin in cancer stem-like cellsResearch in context [PDF]

EBioMedicine, 2019
Background: Cell division cycle 20 (CDC20) is frequently overexpressed in malignant tumours and involved in the differentiation process of hematopoietic stem cells.
Qin Zhang, Hai Huang, Ao Liu, Jiang Li, Chunying Liu, Bin Sun, Lu Chen, Yi Gao, Danfeng Xu, Changqing Su   +9 more
doaj   +2 more sources

Cell division cycle 20 promotes tumor progression and predicts poor clinical outcome in childhood and adult adrenocortical carcinoma [PDF]

Journal of Clinical & Translational Endocrinology
Background: Adrenocortical carcinoma (ACC) is an uncommon and highly aggressive tumor with a grim prognosis. Numerous investigations have elucidated a close association between the dysregulated expression of multiple genes within tumors and the ...
Jiahong Chen, Peisheng Huang, Yongcheng Shi, Shanshan Mo, Cheng-Ya Hsu, Shumin Fang, Chuanfan Zhong, Le Zhang, Lanting Zuo, Jianming Lu, Weide Zhong, Zhuoya Huang, Zhong Dong   +12 more
doaj   +2 more sources

Prognostic significance of CDC20 expression in malignancy patients: A meta-analysis

Frontiers in Oncology, 2022
BackgroundCell Division Cycle Protein 20(CDC20) is reported to promote cancer initiation, progression and drug resistance in many preclinical models and is demonstrated in human cancer tissues.
Feng Xian, Feng Xian, Xuegang Yang, Guohui Xu   +3 more
doaj   +2 more sources

CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma. [PDF]

, 2015
BackgroundCytochrome P450 1B1 (CYP1B1) has been shown to be up-regulated in many types of cancer including renal cell carcinoma (RCC). Several reports have shown that CYP1B1 can influence the regulation of tumor development; however, its role in RCC has ...
Arichi, Naoko, Chang, Inik, Dahiya, Rajvir, Deng, Guoren, Fukuhara, Shinichiro, Hiraki, Miho, Hirata, Hiroshi, Majid, Shahana, Mitsui, Yozo, Shahryari, Varahram, Shiina, Hiroaki, Tanaka, Yuichiro, Wong, Darryn K, Yamamura, Soichiro, Yasumoto, Hiroaki   +14 more
core   +4 more sources