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Leishmania express a functional Cdc20 homologue
Biochemical and Biophysical Research Communications, 2011Our knowledge concerning the mechanisms of cell cycle regulation in organisms belonging to the Trypanosometidae family is limited. Leishmania donovani are parasitic protozoa that cause kala azar, a fatal form of visceral leishmaniasis in humans. Here we provide evidence that the L. donovani genome contains a Cdc20 homologue. Cdc20 is a regulator of the
Listovsky, Tamar +2 more
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Alternative CDC20 translational isoforms tune mitotic arrest duration
Nature, 2023Mitotic defects activate the spindle-assembly checkpoint, which inhibits the anaphase-promoting complex co-activator CDC20 to induce a prolonged cell cycle arrest1,2. Once errors are corrected, the spindle-assembly checkpoint is silenced, allowing anaphase onset to occur.
Mary-Jane Tsang, Iain M. Cheeseman
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Under arrest in mitosis: Cdc20 dies twice
Nature Cell Biology, 2008The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.
Fry, AM, Yamano, H
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Cdc20 mediates D-box-dependent degradation of Sp100
Biochemical and Biophysical Research Communications, 2011Cdc20 is a co-activator of the anaphase-promoting complex/cyclosome (APC/C complex), which recruits substrates at particular phases of the cell cycle and mediates their degradation. Sp100 is a PML-NB scaffold protein, which localizes to nuclear particles during interphase and disperses from them during mitosis, participates in viral resistance ...
Ran, Wang +5 more
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Regulation of APC–Cdc20 by the spindle checkpoint
Current Opinion in Cell Biology, 2002The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase-promoting complex, a large ubiquitin ligase required for chromosome segregation.
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Budding Yeast Cdc20: A Target of the Spindle Checkpoint
Science, 1998The spindle checkpoint regulates the cell division cycle by keeping cells with defective spindles from leaving mitosis. In the two-hybrid system, three proteins that are components of the checkpoint, Mad1, Mad2, and Mad3, were shown to interact with Cdc20, a protein required for exit from mitosis.
L H, Hwang +7 more
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Cdc20 control of cell fate during prolonged mitotic arrest
BioEssays, 2011AbstractThe fate of cells arrested in mitosis by antimitotic compounds is complex but is influenced by competition between pathways promoting cell death and pathways promoting mitotic exit. As components of both of these pathways are regulated by Cdc20‐dependent degradation, I hypothesize that variations in Cdc20 protein levels, rather than mutations ...
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CDC20 is differentially expressed in glioblastoma.
Glioblastoma is difficult to treat and patients are often provided poor prognosis (1), indicating a requirement for therapeutic target identification and drug development. Differentially expressed genes represent by definition among the most promising targets for the development of novel chemotherapies (2, 3).openaire +1 more source