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Identification of key candidate genes for ovarian cancer using integrated statistical and machine learning approaches. [PDF]

Brief Bioinform
Hossain MA, Asa TA, Islam MS, Rahman MZ, Moni MA.   +4 more
europepmc   +1 more source

Balancing Efficiency and Equity in Population-Wide CKD Screening.

JAMA Netw Open
Cusick MM, Tisdale RL, Adams AS, Chertow GM, Owens DK, Salomon JA, Goldhaber-Fiebert JD.   +6 more
europepmc   +1 more source

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Targeting Cdc20 for cancer therapy

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2022
The Anaphase-Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase, and two co-activators, Cdc20 and Cdh1, enable the ubiquitin-dependent proteasomal degradation of various critical cell cycle regulators and govern cell division in a timely and precise manner.
Seung Min, Jeong, Quyen Thu, Bui, Minseok, Kwak, Ji Yeon, Lee, Peter Chang-Whan, Lee   +4 more
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Leishmania express a functional Cdc20 homologue

Biochemical and Biophysical Research Communications, 2011
Our knowledge concerning the mechanisms of cell cycle regulation in organisms belonging to the Trypanosometidae family is limited. Leishmania donovani are parasitic protozoa that cause kala azar, a fatal form of visceral leishmaniasis in humans. Here we provide evidence that the L. donovani genome contains a Cdc20 homologue. Cdc20 is a regulator of the
Listovsky, Tamar, Brandeis, Michael, Zilberstein, Dan   +2 more
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Alternative CDC20 translational isoforms tune mitotic arrest duration

Nature, 2023
Mitotic defects activate the spindle-assembly checkpoint, which inhibits the anaphase-promoting complex co-activator CDC20 to induce a prolonged cell cycle arrest1,2. Once errors are corrected, the spindle-assembly checkpoint is silenced, allowing anaphase onset to occur.
Mary-Jane Tsang, Iain M. Cheeseman
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Under arrest in mitosis: Cdc20 dies twice

Nature Cell Biology, 2008
The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.
Fry, AM, Yamano, H
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Cdc20-APC in Synapse Formation

Science, 2009
The ubiquitin ligase Cdc20-APC is required for proper synapse formation in the developing rat brain.
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Cdc20 mediates D-box-dependent degradation of Sp100

Biochemical and Biophysical Research Communications, 2011
Cdc20 is a co-activator of the anaphase-promoting complex/cyclosome (APC/C complex), which recruits substrates at particular phases of the cell cycle and mediates their degradation. Sp100 is a PML-NB scaffold protein, which localizes to nuclear particles during interphase and disperses from them during mitosis, participates in viral resistance ...
Ran, Wang, Ke-min, Li, Cai-hong, Zhou, Jing-lun, Xue, Chao-neng, Ji, Jin-zhong, Chen   +5 more
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Regulation of APC–Cdc20 by the spindle checkpoint

Current Opinion in Cell Biology, 2002
The spindle checkpoint ensures the fidelity of chromosome segregation in mitosis and meiosis. In response to defects in the mitotic apparatus, it blocks the activity of the anaphase-promoting complex, a large ubiquitin ligase required for chromosome segregation.
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