Results 21 to 30 of about 18,977 (237)
Frontiers in Bioengineering and Biotechnology, 2023 Objectives An acute injury is often accompanied by tissue regeneration. In this process, epithelial cells show a tendency of cell proliferation under the induction of injury stress, inflammatory factors, and other factors, accompanied by a temporary ...
Jihang Shi +17 more
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Effects of SP600125 on Proliferation and Invasion of Human Cervical Cancer HeLa Cells
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the effect of SP600125 on the proliferation, cell cycle, apoptosis and invasion of human cervical cancer HeLa cells. Methods CCK-8 method was used to detect the proliferation of HeLa cells treated with different concentrations of
MO Yanxiu +4 more
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Cdc20, an Activator at Last [PDF]
Molecular Cell, 2008 In this issue of Molecular Cell, Kimata et al. (2008) show that Cdc20 functions not only in the recruitment of substrates to the anaphase-promoting complex but also in its activation.
Benanti, Jennifer A., Toczyski, David P.
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Mad2 “Opens” Cdc20 for BubR1 Binding [PDF]
Molecular Cell, 2013 In this issue of Molecular Cell, Han et al. (2013) demonstrate that Mad2 induces a conformational change in Cdc20 that permits BubR1 binding, thereby producing the physiologically relevant APC/C(Cdc20) inhibitor.
Caldas, Gina V., DeLuca, Jennifer G.
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Coupling of Cdc20 inhibition and activation by BubR1 [PDF]
Journal of Cell Biology, 2020 Tight regulation of the APC/C-Cdc20 ubiquitin ligase that targets Cyclin B1 for degradation is important for mitotic fidelity. The spindle assembly checkpoint (SAC) inhibits Cdc20 through the mitotic checkpoint complex (MCC). In addition, phosphorylation of Cdc20 by Cyclin B1-Cdk1 independently inhibits APC/C-Cdc20 activation.
Jamin B. Hein +4 more
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Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest [PDF]
Current Biology, 2017 During mitosis, cells must segregate the replicated copies of their genome to their daughter cells with extremely high fidelity. Segregation errors lead to an abnormal chromosome number (aneuploidy), which typically results in disease or cell death [1].
May, Karen M. +2 more
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CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma. [PDF]
, 2015 BackgroundCytochrome P450 1B1 (CYP1B1) has been shown to be up-regulated in many types of cancer including renal cell carcinoma (RCC). Several reports have shown that CYP1B1 can influence the regulation of tumor development; however, its role in RCC has ...
Arichi, Naoko +14 more
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Journal of Experimental & Clinical Cancer Research, 2022 Cell division cycle 20 homologue (CDC20) is a well-known regulator of cell cycle, as it controls the correct segregation of chromosomes during mitosis. Many studies have focused on the biological role of CDC20 in cancer development, as alterations of its
Samantha Bruno +5 more
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Modeling Dual Pathways for the Metazoan Spindle Assembly Checkpoint [PDF]
, 2006 Using computational modelling, we investigate mechanisms of signal transduction focusing on the spindle assembly checkpoint where a single unattached kinetochore is able to signal to prevent cell cycle progression.
Acquaviva +29 more
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Experimental Hematology & Oncology, 2023 Background Cell cycle dysregulation characterized by cyclin D1 overexpression is common in mantle cell lymphoma (MCL), while mitotic disorder was less studied. Cell division cycle 20 homologue (CDC20), an essential mitotic regulator, was highly expressed
Yingtong Chen +9 more
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