Results 21 to 30 of about 20,775 (267)

Overexpression of CDC20 Confer a Poorer Prognosis in Bladder Cancer Identified by Gene Co-Expression Network Analysis [PDF]

Diagnostics
Background/Objectives: Bladder cancer (BCa) ranks as the tenth most prevalent malignancy worldwide, characterized by high morbidity and mortality rates.
Xuejian Yang, Yunjie Guo, Lanyu Wang, Zengli Miao, Xiaojie Lu, Jun Ruan, Wei Tian   +6 more
doaj   +2 more sources

Identification of Novel Mutations in CDC20: Expanding the Mutational Spectrum for Female Infertility

Frontiers in Cell and Developmental Biology, 2021
Oocyte maturation and fertilization are fundamental processes for successful human reproduction, and abnormalities in these processes will cause infertility.
Lin Zhao, Lin Zhao, Yichun Guan, Qingxia Meng, Weijie Wang, Ling Wu, Biaobang Chen, Jijun Hu, Jiawei Zhu, Zhihua Zhang, Jian Mu, Yao Chen, Yiming Sun, Tianyu Wu, Wenjing Wang, Zhou Zhou, Jie Dong, Yang Zeng, Ruyi Liu, Qiaoli Li, Jing Du, Yanping Kuang, Qing Sang, Lei Wang   +23 more
doaj   +2 more sources

CDC20 regulates sensitivity to chemotherapy and radiation in glioblastoma stem cells.

PLoS ONE, 2022
Glioblastoma stem cells (GSCs) are an important subpopulation in glioblastoma, implicated in tumor growth, tumor recurrence, and radiation resistance. Understanding the cellular mechanisms for chemo- and radiation resistance could lead to the development
Diane D Mao, Ryan T Cleary, Amit Gujar, Tatenda Mahlokozera, Albert H Kim   +4 more
doaj   +2 more sources

A signature of correlated CDC20 and UBCH10 expression indicates poor prognosis in primary head and neck squamous cell carcinoma [PDF]

BMC Cancer
Background The orchestration of mitotic checkpoint execution depends on the enzymatic activity of the anaphase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase.
Ratnadip Paul, Sayani Sinharay, Debanil Dhar, Purandar Sarkar, Puja Chakraborty, Saradindu Ghosh, Anup Roy, Abhik Saha, Susanta Roychoudhury, Somsubhra Nath   +9 more
doaj   +2 more sources

NSUN4 Facilitates the Activity of Oncogenic Protein CDC20 to Promote NSCLC Development by Mediating m5C Modification of CDC20 mRNA [PDF]

Thoracic Cancer
Background 5‐methylcytosine (m5C) methylation is the crucial posttranscriptional modification of RNA. NSUN4, a methyltransferase for m5C methylation, contributes to lung tumorigenesis. Here, we determined the precise action of NSUN4 on the development of
Zhilong Li, Xianzhen Wu
doaj   +2 more sources

Based on machine learning, CDC20 has been identified as a biomarker for postoperative recurrence and progression in stage I & II lung adenocarcinoma patients

Frontiers in Oncology
ObjectiveBy utilizing machine learning, we can identify genes that are associated with recurrence, invasion, and tumor stemness, thus uncovering new therapeutic targets.MethodsTo begin, we obtained a gene set related to recurrence and invasion from the ...
Rui Miao, Rui Miao, Rui Miao, Zhi Xu, Zhi Xu, Tao Han, Tao Han, Yafeng Liu, Yafeng Liu, Jiawei Zhou, Jiawei Zhou, Jianqiang Guo, Jianqiang Guo, Yingru Xing, Yingru Xing, Ying Bai, Ying Bai, Zhonglei He, Zhonglei He, Jing Wu, Jing Wu, Wenxin Wang, Wenxin Wang, Dong Hu, Dong Hu, Dong Hu   +25 more
doaj   +2 more sources

High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors. [PDF]

EMBO Rep
Spindle assembly checkpoint (SAC) inhibitors are a recently developed class of drugs, which perturb chromosome segregation during cell division, induce chromosomal instability (CIN), and eventually lead to cell death.
Zheng S, Raz L, Zhou L, Cohen-Sharir Y, Tian R, Ippolito MR, Gianotti S, Saad R, Wardenaar R, Broekhuis M, Suarez Peredo Rodriguez M, Wobben S, van den Brink A, Bakker P, Santaguida S, Foijer F, Ben-David U, Ben-David U.   +17 more
europepmc   +2 more sources

Parallel Parkin: Cdc20 Takes a New Partner [PDF]

Molecular Cell, 2015
CDC20 and CDH1 are well-established substrate receptors for the Anaphase Promoting Complex/Cyclosome (APC/C). In this issue of Molecular Cell, Lee et al. (2015) show that these adaptors can also target cell cycle proteins for destruction through a second ubiquitin ligase, Parkin.
Fernando Meza-Gutierrez, Frances V Hundley, David P. Toczyski   +2 more
openalex   +5 more sources

Molecular mechanism of Mad2 conformational conversion promoted by the Mad2-interaction motif of Cdc20. [PDF]

Protein Sci
Yu CWH, Fischer ES, Greener JG, Yang J, Zhang Z, Freund SMV, Barford D.   +6 more
europepmc   +3 more sources

Coupling of Cdc20 inhibition and activation by BubR1 [PDF]

Journal of Cell Biology, 2020
Tight regulation of the APC/C-Cdc20 ubiquitin ligase that targets Cyclin B1 for degradation is important for mitotic fidelity. The spindle assembly checkpoint (SAC) inhibits Cdc20 through the mitotic checkpoint complex (MCC). In addition, phosphorylation of Cdc20 by Cyclin B1-Cdk1 independently inhibits APC/C-Cdc20 activation.
Jamin B. Hein, Dimitriya H. Garvanska, Isha Nasa, Arminja N. Kettenbach, Jakob Nilsson   +4 more
openaire   +3 more sources