Results 21 to 30 of about 18,904 (232)
Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]
, 2014 The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
Corbishley, Stephen +5 more
core +11 more sources
Kaohsiung Journal of Medical Sciences, 2022 Cell division cycle 20 (CDC20) and microRNAs (miRNAs) are differentially expressed in non‐small cell lung cancer (NSCLC). The current study aimed to investigate the role of miR‐1321 and miR‐7515 regulation in CDC20 during NSCLC development.
Hao Hu +7 more
doaj +1 more source
Knockdown of CDC20 promotes adipogenesis of bone marrow-derived stem cells by modulating β-catenin
Stem Cell Research & Therapy, 2022 Background Bone is a rigid organ that provides physical protection and support to vital organs of the body. Bone loss disorders are commonly associated with increased bone marrow adipose tissue.
Yangge Du +3 more
doaj +1 more source
Cdc20-APC in Synapse Formation [PDF]
Science, 2009 The ubiquitin ligase Cdc20-APC is required for proper synapse formation in the developing rat brain.
Yue, Yang +8 more
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Effects of SP600125 on Proliferation and Invasion of Human Cervical Cancer HeLa Cells
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the effect of SP600125 on the proliferation, cell cycle, apoptosis and invasion of human cervical cancer HeLa cells. Methods CCK-8 method was used to detect the proliferation of HeLa cells treated with different concentrations of
MO Yanxiu +4 more
doaj +1 more source
Cdc20, an Activator at Last [PDF]
Molecular Cell, 2008 In this issue of Molecular Cell, Kimata et al. (2008) show that Cdc20 functions not only in the recruitment of substrates to the anaphase-promoting complex but also in its activation.
Benanti, Jennifer A., Toczyski, David P.
openaire +2 more sources
Frontiers in Bioengineering and Biotechnology, 2023 Objectives An acute injury is often accompanied by tissue regeneration. In this process, epithelial cells show a tendency of cell proliferation under the induction of injury stress, inflammatory factors, and other factors, accompanied by a temporary ...
Jihang Shi +17 more
doaj +1 more source
Targeting Cdc20 as a novel cancer therapeutic strategy [PDF]
Pharmacology & Therapeutics, 2015 The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub-complexes, APC(Cdc20) and APC(Cdh1), respectively. Emerging evidence has begun to reveal that Cdc20 and Cdh1 have opposing functions in tumorigenesis.
Lixia Wang +5 more
openalex +3 more sources
Mad2 “Opens” Cdc20 for BubR1 Binding [PDF]
Molecular Cell, 2013 In this issue of Molecular Cell, Han et al. (2013) demonstrate that Mad2 induces a conformational change in Cdc20 that permits BubR1 binding, thereby producing the physiologically relevant APC/C(Cdc20) inhibitor.
Caldas, Gina V., DeLuca, Jennifer G.
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Coupling of Cdc20 inhibition and activation by BubR1 [PDF]
Journal of Cell Biology, 2020 Tight regulation of the APC/C-Cdc20 ubiquitin ligase that targets Cyclin B1 for degradation is important for mitotic fidelity. The spindle assembly checkpoint (SAC) inhibits Cdc20 through the mitotic checkpoint complex (MCC). In addition, phosphorylation of Cdc20 by Cyclin B1-Cdk1 independently inhibits APC/C-Cdc20 activation.
Jamin B. Hein +4 more
openaire +3 more sources