Results 31 to 40 of about 20,775 (267)
PRMT6-CDC20 facilitates glioblastoma progression via the degradation of CDKN1B
Oncogene, 2023 PRMT6, a type I arginine methyltransferase, di-methylates the arginine residues of both histones and non-histones asymmetrically. Increasing evidence indicates that PRMT6 plays a tumor mediator involved in human malignancies.
Ji Wang +11 more
semanticscholar +1 more source
Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]
, 2014 The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
Corbishley, Stephen +5 more
core +9 more sources
Knockdown of CDC20 promotes adipogenesis of bone marrow-derived stem cells by modulating β-catenin
Stem Cell Research & Therapy, 2022 Background Bone is a rigid organ that provides physical protection and support to vital organs of the body. Bone loss disorders are commonly associated with increased bone marrow adipose tissue.
Yangge Du +3 more
doaj +1 more source
Cdc20, an Activator at Last [PDF]
Molecular Cell, 2008 In this issue of Molecular Cell, Kimata et al. (2008) show that Cdc20 functions not only in the recruitment of substrates to the anaphase-promoting complex but also in its activation.
Benanti, Jennifer A., Toczyski, David P.
openaire +2 more sources
Targeting Cdc20 as a novel cancer therapeutic strategy [PDF]
Pharmacology & Therapeutics, 2015 The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub-complexes, APC(Cdc20) and APC(Cdh1), respectively. Emerging evidence has begun to reveal that Cdc20 and Cdh1 have opposing functions in tumorigenesis.
Lixia Wang +5 more
openalex +3 more sources
The potential role of CDC20 in tumorigenesis, cancer progression and therapy: A narrative review
Medicine, 2023 The cell division cycle 20 homologue (CDC20) is known to regulate the cell cycle. Many studies have suggested that dysregulation of CDC20 is associated with various pathological processes in malignant solid tumors, including tumorigenesis, progression ...
F. Xian +4 more
semanticscholar +1 more source
Frontiers in Bioengineering and Biotechnology, 2023 Objectives An acute injury is often accompanied by tissue regeneration. In this process, epithelial cells show a tendency of cell proliferation under the induction of injury stress, inflammatory factors, and other factors, accompanied by a temporary ...
Jihang Shi +17 more
doaj +1 more source
Effects of SP600125 on Proliferation and Invasion of Human Cervical Cancer HeLa Cells
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the effect of SP600125 on the proliferation, cell cycle, apoptosis and invasion of human cervical cancer HeLa cells. Methods CCK-8 method was used to detect the proliferation of HeLa cells treated with different concentrations of
MO Yanxiu +4 more
doaj +1 more source
Oncology Letters, 2023 Chaperonin-containing tailless complex polypeptide 1 subunit 6A (CCT6A) regulates the proliferation, invasiveness and stemness of numerous types of cancer, and may interact with cell division cycle 20 (CDC20); however, its implication in osteosarcoma ...
Ning Wang, Yong Chen, Jie Wu
semanticscholar +1 more source
The Role of the APC/C and Its Coactivators Cdh1 and Cdc20 in Cancer Development and Therapy
Frontiers in Genetics, 2022 To sustain genomic stability by correct DNA replication and mitosis, cell cycle progression is tightly controlled by the cyclic activity of cyclin-dependent kinases, their binding to cyclins in the respective phase and the regulation of cyclin levels by ...
C. Greil, M. Engelhardt, R. Wäsch
semanticscholar +1 more source