Results 41 to 50 of about 8,872 (149)

Bifurcation analysis of a model of the budding yeast cell cycle

, 2004
We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae.
Battogtokh, Dorjsuren, Tyson, John J.
core   +1 more source

Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison. [PDF]

PLoS ONE, 2018
There is an interest in identifying Anaphase Promoting-Complex/Cyclosome (APC/C) inhibitors that lead to sensitivity to microtubule poisons as a strategy for targeting cancer cells.
Scott C Schuyler, Yueh-Fu Olivia Wu, Hsin-Yu Chen, Yi-Shan Ding, Chia-Jung Lin, Yu-Ting Chu, Ting-Chun Chen, Louis Liao, Wei-Wei Tsai, Anna Huang, Lin-Ing Wang, Ting-Wei Liao, Jia-Hua Jhuo, Vivien Cheng   +13 more
doaj   +1 more source

The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase. [PDF]

, 2018
Smk1 is a meiosis-specific MAP kinase (MAPK) in budding yeast that is required for spore formation. It is localized to prospore membranes (PSMs), the structures that engulf haploid cells during meiosis II (MII).
Diamond, Aviva, Neiman, Aaron M., Omerza, Gregory, Philips, Timothy, Tio, Chong Wai, Winter, Edward   +5 more
core   +3 more sources

Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint

Cell Division, 2007
During mitosis, the genome duplicated during S-phase is synchronously and accurately segregated to the two daughter cells. The spindle checkpoint prevents premature sister-chromatid separation and mitotic exit.
Yu Hongtao, Díaz-Martínez Laura A
doaj   +1 more source

Functional analysis of recurrent CDC20 promoter variants in human melanoma

Communications Biology, 2023
Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks.
Paula M. Godoy, Abimbola Oyedeji, Jacqueline L. Mudd, Vasilios A. Morikis, Anna P. Zarov, Gregory D. Longmore, Ryan C. Fields, Charles K. Kaufman   +7 more
doaj   +1 more source

Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk [PDF]

, 2011
During meiosis, one round of deoxyribonucleic acid replication is followed by two rounds of nuclear division. In Saccharomyces cerevisiae, activation of the Cdc14 early anaphase release (FEAR) network is required for exit from meiosis I but does not lead
Arumugam, Prakash, Kerr, Gary W., Millar, Jonathan B. A., Petronczki, Mark, Sarkar, Sourav, Tibbles, Katherine L.   +5 more
core   +3 more sources

Targeting APC/CCDC20 by Pro-TAME Suppresses Tumor Proliferation and Induces Apoptosis in Endometrial Carcinoma

Clinical and Experimental Obstetrics & Gynecology
Background: Anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that recruits substrates for ubiquitination and subsequent degradation.
Fang Fang, Ke Ni
doaj   +1 more source

High Expression Levels of CDK1 and CDC20 in Patients With Lung Squamous Cell Carcinoma are Associated With Worse Prognosis

Frontiers in Molecular Biosciences, 2021
Purpose: Progress related to the early detection and molecular targeted therapy of lung squamous cell carcinoma (LUSC) remains limited. The goal of our study was to identify key candidate indicators of LUSC.Methods: Three microarray datasets (GSE33532 ...
Huan Deng, Huan Deng, Huan Deng, Huan Deng, Qingqing Hang, Dijian Shen, Dijian Shen, Dijian Shen, Hangjie Ying, Hangjie Ying, Hangjie Ying, Yibi Zhang, Xu Qian, Xu Qian, Xu Qian, Ming Chen, Ming Chen, Ming Chen   +17 more
doaj   +1 more source

The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation [PDF]

, 2005
Deciphering regulatory events that drive malignant transformation represents a major challenge for systems biology. Here we analyzed genome-wide transcription profiling of an in-vitro transformation process.
Assif Yitzhaky, Badie C, Barrett MT, Blatt M, Eytan Domany, Halfon MS, Hoffman WH, Igor Shats, Mantovani R, Michael Milyavsky, Milyavsky M, Or Zuk, Ran Brosh, Roberto Mantovani, Varda Rotter, Yitzhak Pilpel, Yuval Tabach, Zhou X   +17 more
core   +3 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source