Results 41 to 50 of about 18,904 (232)
CDC20 maintains tumor initiating cells
Oncotarget, 2015 Glioblastoma is the most prevalent and lethal primary intrinsic brain tumor. Glioblastoma displays hierarchical arrangement with a population of self-renewing and tumorigenic glioma tumor initiating cells (TICs), or cancer stem cells. While non-neoplastic neural stem cells are generally quiescent, glioblastoma TICs are often proliferative with mitotic ...
Xie, Qi +9 more
openaire +3 more sources
A novel strategy to block mitotic progression for targeted therapyResarch in context
EBioMedicine, 2019 Background: Blockade of mitotic progression is an ideal approach to induce mitotic catastrophe that suppresses cancer cell expansion. Cdc20 is a critical mitotic factor governing anaphase initiation and the exit from mitosis through recruiting substrates
Junlong (Jack) Chi +11 more
doaj +1 more source
A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. [PDF]
, 2012 BackgroundEukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex ...
DaSilva, Lance F +6 more
core +3 more sources
Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]
, 2019 Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G. +5 more
core +2 more sources
EBioMedicine, 2019 Background: Cell division cycle 20 (CDC20) is frequently overexpressed in malignant tumours and involved in the differentiation process of hematopoietic stem cells.
Qin Zhang +9 more
doaj +1 more source
Active Transport Can Greatly Enhance Cdc20:Mad2 Formation [PDF]
International Journal of Molecular Sciences, 2014 To guarantee genomic integrity and viability, the cell must ensure proper distribution of the replicated chromosomes among the two daughter cells in mitosis. The mitotic spindle assembly checkpoint (SAC) is a central regulatory mechanism to achieve this goal.
Bashar Ibrahim, Richard Henze
openaire +2 more sources
Journal of Hematology & Oncology, 2012 Purpose Cell division cycle 20 (CDC20) homolog is an anaphase-promoting complex activator that is essential for cell division, but whether its expression in pancreatic ductal adenocarcinoma (PDAC) is significant is unknown.
Chang David Z +7 more
doaj +1 more source
Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex. [PDF]
PLoS Computational Biology, 2018 The mitotic checkpoint (also called spindle assembly checkpoint) is a signaling pathway that ensures faithful chromosome segregation. Mitotic checkpoint proteins inhibit the anaphase-promoting complex (APC/C) and its activator Cdc20 to prevent precocious
Fridolin Gross +3 more
doaj +1 more source
Pan-cancer noncoding genomic analysis identifies functional CDC20 promoter mutation hotspots
iScience, 2021 Summary: Noncoding DNA sequences occupy more than 98% of the human genome; however, few cancer noncoding drivers have been identified compared with cancer coding drivers, probably because cancer noncoding drivers have a distinct mutation pattern due to ...
Zaoke He +9 more
doaj +1 more source
Novel regulation of mitotic exit by the Cdc42 effectors Gic1 and Gic2 [PDF]
, 2004 Copyright @ The Rockefeller University PressThe guanine nucleotide exchange factor Cdc24, the GTPase Cdc42, and the Cdc42 effectors Cla4 and Ste20, two p21-activated kinases, form a signal transduction cascade that promotes mitotic exit in yeast.
Höfken, T, Schiebel, E
core +2 more sources