Results 41 to 50 of about 20,775 (267)
Mad2 “Opens” Cdc20 for BubR1 Binding [PDF]
Molecular Cell, 2013 In this issue of Molecular Cell, Han et al. (2013) demonstrate that Mad2 induces a conformational change in Cdc20 that permits BubR1 binding, thereby producing the physiologically relevant APC/C(Cdc20) inhibitor.
Caldas, Gina V., DeLuca, Jennifer G.
openaire +2 more sources
Modeling Dual Pathways for the Metazoan Spindle Assembly Checkpoint [PDF]
, 2006 Using computational modelling, we investigate mechanisms of signal transduction focusing on the spindle assembly checkpoint where a single unattached kinetochore is able to signal to prevent cell cycle progression.
Acquaviva +29 more
core +3 more sources
Cdc20 associates with the kinase aurora2/Aik [PDF]
Proceedings of the National Academy of Sciences, 1999 Cdc20/fizzy family proteins are involved in activation of the anaphase-promoting complex/cyclosome, which catalyzes the ubiquitin-dependent proteolysis of cell cycle regulatory proteins such as anaphase inhibitors and mitotic cyclins, leading to chromosome segregation and exit from mitosis.
D C, Farruggio +2 more
openaire +2 more sources
Therapeutic target discovery using Boolean network attractors: avoiding pathological phenotypes [PDF]
, 2014 Target identification, one of the steps of drug discovery, aims at identifying biomolecules whose function should be therapeutically altered in order to cure the considered pathology.
Boissel, Jean-Pierre, Poret, Arnaud
core +4 more sources
Anticancer Research, 2022 Background/Aim: The functions of the specific genes involved in the three types of breast cancer (BC) are unclear. Materials and Methods: A total of 53,805 genes were assessed from the RNA-sequencing database of BC cells and classified into those ...
Christine Song +3 more
semanticscholar +1 more source
Cdc20 in S-phase: The Banquo at Replication’s Banquet [PDF]
Cell Cycle, 2004 The Anaphase Promoting Complex/Cyclosome (APC/C) is an E3 ubiquitin ligase that covalently attaches ubiquitins onto proteins to target them for proteolysis by the 26S proteasome. During mitosis, the APC/C is instrumental in allowing the cell to enter and exit from mitosis. The APC/C accomplishes this by using different specificity factors to recognize,
Catherine A, Andrews +3 more
openaire +2 more sources
M2I-1 disrupts the in vivo interaction between CDC20 and MAD2 and increases the sensitivities of cancer cell lines to anti-mitotic drugs via MCL-1s [PDF]
, 2019 Background Drugs such as taxanes, epothilones, and vinca alkaloids are widely used in the treatment of breast, ovarian, and lung cancers but come with major side effects such as neuropathy and loss of neutrophils and as single agents have a lack of ...
Dang, Nanmao +7 more
core +1 more source
CDC20 facilitates the proliferation of esophageal carcinoma cell by stabilizing NLRP3 expression [PDF]
Zhongguo aizheng zazhiBackground and purpose: Esophageal carcinoma (ESCA) is one of the malignant tumors with high mortality rate, and the underlying mechanism of its development is largely unknown.
GUAN Ruirui, HAO Qian, ZHANG Yaqi, SUN Qinggang, CHEN Yitian, LI Xiumin, ZHOU Xiang, HAN Tao
doaj +1 more source
A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. [PDF]
, 2012 BackgroundEukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex ...
DaSilva, Lance F +6 more
core +3 more sources
International Journal on Biological Sciences, 2021 Purpose: The incidence of hepatocellular carcinoma (HCC) is extremely high, and China accounts for approximately 50% of global liver cancer cases.
Shuai Zhao +11 more
semanticscholar +1 more source