Results 51 to 60 of about 20,775 (267)

Expression of CDC20 in lung adenocarcinoma tissues and its effect on the proliferation and invasion of lung adenocarcinoma cells [PDF]

Zhongguo aizheng zazhi
Background and purpose: Lung adenocarcinoma has the characteristics of difficult early detection, rapid tumor progression and low surgical resection rate.
ZHOU Xueqin, LUAN Yanchao, ZHAO Li, RONG Chaochao, YANG Na
doaj   +1 more source

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. [PDF]

, 2015
The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Corbett, Kevin D, Moeller, Arne, Rosenberg, Scott C, Speir, Jeffrey A, Su, Tiffany Y, Ye, Qiaozhen   +5 more
core   +2 more sources

A novel strategy to block mitotic progression for targeted therapyResarch in context

EBioMedicine, 2019
Background: Blockade of mitotic progression is an ideal approach to induce mitotic catastrophe that suppresses cancer cell expansion. Cdc20 is a critical mitotic factor governing anaphase initiation and the exit from mitosis through recruiting substrates
Junlong (Jack) Chi, Hongchun Li, Zhuan Zhou, Javier Izquierdo-Ferrer, Yifan Xue, Cindy M. Wavelet, Gary E. Schiltz, Bin Zhang, Massimo Cristofanilli, Xinghua Lu, Ivet Bahar, Yong Wan   +11 more
doaj   +1 more source

Chromobox 4 (CBX4) promotes tumor progression and stemness via activating CDC20 in gastric cancer.

Journal of Gastrointestinal Oncology, 2022
Background The Chromobox homolog 4 (CBX4) has been found to be overexpressed in multiple malignancies. However, the associations between CBX4 and gastric cancer (GC) have remained unclear.
Wen Li, Honghui Chen, Zheng-Gen Wang, Jingjing Liu, Xinan Lei, Wen Chen   +5 more
semanticscholar   +1 more source

Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]

, 2019
Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G., Dunn, Michael, Jowsey, Paul, Meyer, Stephanie K., Porter, Andrew, Vidier, Daniel S.   +5 more
core   +2 more sources

Role of phosphorylation of Cdc20 in the regulation of the action of APC/C in mitosis

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance The ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) is essential for the control of mitosis, and its action is tightly regulated.
Danielle Shevah-Sitry, Shirly Miniowitz-Shemtov, Adar Teichner, S. Kaisari, A. Hershko   +4 more
semanticscholar   +1 more source

Novel regulation of mitotic exit by the Cdc42 effectors Gic1 and Gic2 [PDF]

, 2004
Copyright @ The Rockefeller University PressThe guanine nucleotide exchange factor Cdc24, the GTPase Cdc42, and the Cdc42 effectors Cla4 and Ste20, two p21-activated kinases, form a signal transduction cascade that promotes mitotic exit in yeast.
Höfken, T, Schiebel, E
core   +2 more sources

A Novel Gene Signature Based on CDC20 and FCN3 for Prediction of Prognosis and Immune Features in Patients with Hepatocellular Carcinoma

Journal of Immunological Research, 2022
Long‐term survivals of patients with hepatocellular carcinoma (HCC) remain unfavorable, which is largely attributed to active carcinogenesis. Growing studies have suggested that the reliable gene signature could act as an independent prognosis factor for
X. Lai, Yakun Wu, Guoqing Hong, Jun-ke Li, Qing Luo, Jin Yuan, Guo-hua Dai, Shuang Liu, Hua-Guo Feng   +8 more
semanticscholar   +1 more source

Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression

Journal of Hematology & Oncology, 2012
Purpose Cell division cycle 20 (CDC20) homolog is an anaphase-promoting complex activator that is essential for cell division, but whether its expression in pancreatic ductal adenocarcinoma (PDAC) is significant is unknown.
Chang David Z, Ma Ying, Ji Baoan, Liu Yan, Hwu Patrick, Abbruzzese James L, Logsdon Craig, Wang Huamin   +7 more
doaj   +1 more source

Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex. [PDF]

PLoS Computational Biology, 2018
The mitotic checkpoint (also called spindle assembly checkpoint) is a signaling pathway that ensures faithful chromosome segregation. Mitotic checkpoint proteins inhibit the anaphase-promoting complex (APC/C) and its activator Cdc20 to prevent precocious
Fridolin Gross, Paolo Bonaiuti, Silke Hauf, Andrea Ciliberto   +3 more
doaj   +1 more source