Results 51 to 60 of about 18,977 (237)

Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]

open access: yes, 2014
The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
core   +2 more sources

Conditional knockout of Cdc20 attenuates osteogenesis in craniofacial bones

open access: yesTissue and Cell, 2022
Abstract Background: Craniofacial bone defects cause significant problems to patients with harmful consequences. Mesenchymal stem cells (MSCs) can self-renew and exhibit multilineage differentiation, which could be applied to bone regeneration. However, craniofacial bone tissue MSCs have unique properties, differing in their characteristics to ...
Yawen, Cheng   +4 more
openaire   +2 more sources

Inhibition of CDC20 potentiates anti-tumor immunity through facilitating GSDME-mediated pyroptosis in prostate cancer

open access: yesExperimental Hematology & Oncology, 2023
Background Increasing evidence suggests that immunotherapy, especially immune checkpoint inhibitors (ICIs), has the potential to facilitate long-term survival in various cancer besides prostate cancer.
Fei Wu   +8 more
doaj   +1 more source

Baculovirus expression: tackling the complexity challenge [PDF]

open access: yes, 2013
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Barford, David   +3 more
core   +2 more sources

CDC20 associated with cancer metastasis and novel mushroom‑derived CDC20 inhibitors with antimetastatic activity

open access: yesInternational Journal of Oncology, 2019
Aberrant expression of cell division cycle 20 (CDC20) is associated with malignant progression and poor prognosis in various types of cancer. The development of specific CDC20 inhibitors may be a novel strategy for the treatment of cancer with elevated expression of CDC20.
Shujie, Cheng   +2 more
openaire   +3 more sources

Targeting Cdc20 as a novel cancer therapeutic strategy [PDF]

open access: yesPharmacology & Therapeutics, 2015
The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub-complexes, APC(Cdc20) and APC(Cdh1), respectively. Emerging evidence has begun to reveal that Cdc20 and Cdh1 have opposing functions in tumorigenesis.
Lixia, Wang   +5 more
openaire   +2 more sources

Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. [PDF]

open access: yesPLoS ONE, 2011
Cdc20-anaphase promoting complex/cyclosome (Cdc20-APC/C) E3 ubiquitin ligase activity is essential for orderly mitotic progression. The deubiqituinase USP44 was identified as a key regulator of APC/C and has been proposed to suppress Cdc20-APC/C activity
Ying Zhang   +2 more
doaj   +1 more source

Prognostic significance of CDC20 expression in malignancy patients: A meta-analysis

open access: yesFrontiers in Oncology, 2022
BackgroundCell Division Cycle Protein 20(CDC20) is reported to promote cancer initiation, progression and drug resistance in many preclinical models and is demonstrated in human cancer tissues.
Feng Xian   +3 more
doaj   +1 more source

An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination [PDF]

open access: yes, 2012
The Anaphase-Promoting Complex/Cyclosome (APC) is a ubiquitin ligase required for exit from mitosis. We previously showed that Tosyl Arginine Methyl Ester (TAME) inhibits APC-dependent proteolysis by competing with the C-terminal IR-tail of the APC ...
King, Randall Wharton, Zeng, Xing
core   +1 more source

Identification of Novel Mutations in CDC20: Expanding the Mutational Spectrum for Female Infertility

open access: yesFrontiers in Cell and Developmental Biology, 2021
Oocyte maturation and fertilization are fundamental processes for successful human reproduction, and abnormalities in these processes will cause infertility.
Lin Zhao   +23 more
doaj   +1 more source

Home - About - Disclaimer - Privacy