Results 61 to 70 of about 20,775 (267)
Pan-cancer noncoding genomic analysis identifies functional CDC20 promoter mutation hotspots
iScience, 2021 Summary: Noncoding DNA sequences occupy more than 98% of the human genome; however, few cancer noncoding drivers have been identified compared with cancer coding drivers, probably because cancer noncoding drivers have a distinct mutation pattern due to ...
Zaoke He +9 more
doaj +1 more source
CDC20 maintains tumor initiating cells
Oncotarget, 2015 Glioblastoma is the most prevalent and lethal primary intrinsic brain tumor. Glioblastoma displays hierarchical arrangement with a population of self-renewing and tumorigenic glioma tumor initiating cells (TICs), or cancer stem cells. While non-neoplastic neural stem cells are generally quiescent, glioblastoma TICs are often proliferative with mitotic ...
Xie, Qi +9 more
openaire +3 more sources
A new Mad2-interacting domain of Cdc20 is critical for the function of Mad2–Cdc20 complex in the spindle assembly checkpoint [PDF]
Biochemical Journal, 2006 Interaction between Mad2 and Cdc20 (cell division cycle 20) is a key event during spindle assembly checkpoint activation. In the past, an N-terminal peptide containing amino acid residues 111–150 of Cdc20 was shown to bind Mad2 much better than the full-length Cdc20 protein.
Gourish, Mondal +2 more
openaire +2 more sources
Frontiers in Bioengineering and Biotechnology, 2015 The cell cycle proteins are key regulators of cell cycle progression whose de-regulation is one of the causes of breast cancer. RNA interference (RNAi) is an endogenous mechanism to regulate gene expression and it could serve as the basis of regulating ...
Manoj eParmar +6 more
doaj +1 more source
An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination [PDF]
, 2012 The Anaphase-Promoting Complex/Cyclosome (APC) is a ubiquitin ligase required for exit from mitosis. We previously showed that Tosyl Arginine Methyl Ester (TAME) inhibits APC-dependent proteolysis by competing with the C-terminal IR-tail of the APC ...
King, Randall Wharton, Zeng, Xing
core +1 more source
Baculovirus expression: tackling the complexity challenge [PDF]
, 2013 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Barford, David +3 more
core +2 more sources
CDC20-Mediated hnRNPU Ubiquitination Regulates Chromatin Condensation and Anti-Cancer Drug Response
Cancers, 2022 Simple Summary CDC20 has been shown to function as an oncogene in multiple human malignancies and is recognized as a promising target for developing novel therapeutic strategies.
Cindy Wavelet-Vermuse +5 more
semanticscholar +1 more source
International Journal of Oncology, 2019 Aberrant expression of cell division cycle 20 (CDC20) is associated with malignant progression and poor prognosis in various types of cancer. The development of specific CDC20 inhibitors may be a novel strategy for the treatment of cancer with elevated expression of CDC20.
Shujie, Cheng +2 more
openaire +3 more sources
Conditional knockout of Cdc20 attenuates osteogenesis in craniofacial bones
Tissue and Cell, 2022 Abstract Background: Craniofacial bone defects cause significant problems to patients with harmful consequences. Mesenchymal stem cells (MSCs) can self-renew and exhibit multilineage differentiation, which could be applied to bone regeneration. However, craniofacial bone tissue MSCs have unique properties, differing in their characteristics to ...
Yawen, Cheng +4 more
openaire +2 more sources
Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. [PDF]
PLoS ONE, 2011 Cdc20-anaphase promoting complex/cyclosome (Cdc20-APC/C) E3 ubiquitin ligase activity is essential for orderly mitotic progression. The deubiqituinase USP44 was identified as a key regulator of APC/C and has been proposed to suppress Cdc20-APC/C activity
Ying Zhang +2 more
doaj +1 more source