Results 61 to 70 of about 20,500 (223)
Journal of clinical laboratory analysis (Print), 2022 CCT6A promotes several carcinomas' growth and invasion in multiple ways, and it relates to CCNB1 and PLK1 through its interaction with CDC20 via protein–protein interaction bioinformatics.
Wei Peng +4 more
semanticscholar +1 more source
An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination [PDF]
, 2012 The Anaphase-Promoting Complex/Cyclosome (APC) is a ubiquitin ligase required for exit from mitosis. We previously showed that Tosyl Arginine Methyl Ester (TAME) inhibits APC-dependent proteolysis by competing with the C-terminal IR-tail of the APC ...
King, Randall Wharton, Zeng, Xing
core +1 more source
REC8 inhibits proliferation, migration and invasion of breast cancer cells by targeting CDC20
Molecular Medicine Reports, 2022 Breast cancer is one of the most types of common malignant tumor in women. REC8 is a known tumor suppressor in several types of cancer; however, the role of REC8 in breast cancer remains unknown.
Shaodan He, Danping Liu, Zhuanhong Chen
semanticscholar +1 more source
Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. [PDF]
, 2017 The HORMA domain is a highly conserved protein-protein interaction module found in eukaryotic signaling proteins including the spindle assembly checkpoint protein Mad2 and the meiotic HORMAD proteins.
Corbett, Kevin D +2 more
core +2 more sources
Genetics Research, 2022 Uterine Corpus Endometrial Carcinoma (UCEC), the most common gynecologic malignancy in developed countries, remains to be a major public health problem. Further studies are surely needed to elucidate the tumorigenesis of UCEC.
Qiaoling Zhang, Yingmei Wang, F. Xue
semanticscholar +1 more source
Developmental regulation of an organelle tether coordinates mitochondrial remodeling in meiosis. [PDF]
, 2018 Cellular differentiation involves remodeling cellular architecture to transform one cell type to another. By investigating mitochondrial dynamics during meiotic differentiation in budding yeast, we sought to understand how organelle morphogenesis is ...
Berchowitz, Luke +5 more
core +2 more sources
The influence of catalysis on mad2 activation dynamics.
PLoS Biology, 2009 Mad2 is a key component of the spindle assembly checkpoint, a safety device ensuring faithful sister chromatid separation in mitosis. The target of Mad2 is Cdc20, an activator of the anaphase-promoting complex/cyclosome (APC/C).
Marco Simonetta +8 more
doaj +1 more source
Bifurcation analysis of a model of the budding yeast cell cycle
, 2004 We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae.
Battogtokh, Dorjsuren, Tyson, John J.
core +1 more source
Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison. [PDF]
PLoS ONE, 2018 There is an interest in identifying Anaphase Promoting-Complex/Cyclosome (APC/C) inhibitors that lead to sensitivity to microtubule poisons as a strategy for targeting cancer cells.
Scott C Schuyler +13 more
doaj +1 more source
The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase. [PDF]
, 2018 Smk1 is a meiosis-specific MAP kinase (MAPK) in budding yeast that is required for spore formation. It is localized to prospore membranes (PSMs), the structures that engulf haploid cells during meiosis II (MII).
Diamond, Aviva +5 more
core +3 more sources