Results 71 to 80 of about 20,775 (267)
Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]
, 2014 The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
core +2 more sources
Genetics Research, 2022 Uterine Corpus Endometrial Carcinoma (UCEC), the most common gynecologic malignancy in developed countries, remains to be a major public health problem. Further studies are surely needed to elucidate the tumorigenesis of UCEC.
Qiaoling Zhang, Yingmei Wang, F. Xue
semanticscholar +1 more source
Bifurcation analysis of a model of the budding yeast cell cycle
, 2004 We study the bifurcations of a set of nine nonlinear ordinary differential equations that describe the regulation of the cyclin-dependent kinase that triggers DNA synthesis and mitosis in the budding yeast, Saccharomyces cerevisiae.
Battogtokh, Dorjsuren, Tyson, John J.
core +1 more source
Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. [PDF]
, 2017 The HORMA domain is a highly conserved protein-protein interaction module found in eukaryotic signaling proteins including the spindle assembly checkpoint protein Mad2 and the meiotic HORMAD proteins.
Corbett, Kevin D +2 more
core +2 more sources
Control of APC-Cdc20 by the Tumor Suppressor RASSF1A [PDF]
Cell Cycle, 2004 The tumor suppressor gene RASSF1A is frequently hypermethylated in various tumors. However, how RASSF1A functions in tumor suppression was unknown. Our study shows that RASSF1A regulates the stability of mitotic cyclins and the timing of mitotic progression by inhibiting APC-Cdc20.
Song, MS Song, Min Sup +1 more
openaire +2 more sources
Proceedings of the National Academy of Sciences of the United States of AmericaSignificance Cdc20 is involved in both positive and negative regulation of the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C) at different stages of mitosis.
Danielle Sitry-Shevah +3 more
semanticscholar +1 more source
Journal of clinical laboratory analysis (Print), 2022 CCT6A promotes several carcinomas' growth and invasion in multiple ways, and it relates to CCNB1 and PLK1 through its interaction with CDC20 via protein–protein interaction bioinformatics.
Wei Peng +4 more
semanticscholar +1 more source
Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest [PDF]
Current Biology, 2017 During mitosis, cells must segregate the replicated copies of their genome to their daughter cells with extremely high fidelity. Segregation errors lead to an abnormal chromosome number (aneuploidy), which typically results in disease or cell death [1].
May, Karen M. +2 more
openaire +4 more sources
The influence of catalysis on mad2 activation dynamics.
PLoS Biology, 2009 Mad2 is a key component of the spindle assembly checkpoint, a safety device ensuring faithful sister chromatid separation in mitosis. The target of Mad2 is Cdc20, an activator of the anaphase-promoting complex/cyclosome (APC/C).
Marco Simonetta +8 more
doaj +1 more source
Developmental regulation of an organelle tether coordinates mitochondrial remodeling in meiosis. [PDF]
, 2018 Cellular differentiation involves remodeling cellular architecture to transform one cell type to another. By investigating mitochondrial dynamics during meiotic differentiation in budding yeast, we sought to understand how organelle morphogenesis is ...
Berchowitz, Luke +5 more
core +2 more sources