Results 71 to 80 of about 18,977 (237)

Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison. [PDF]

PLoS ONE, 2018
There is an interest in identifying Anaphase Promoting-Complex/Cyclosome (APC/C) inhibitors that lead to sensitivity to microtubule poisons as a strategy for targeting cancer cells.
Scott C Schuyler, Yueh-Fu Olivia Wu, Hsin-Yu Chen, Yi-Shan Ding, Chia-Jung Lin, Yu-Ting Chu, Ting-Chun Chen, Louis Liao, Wei-Wei Tsai, Anna Huang, Lin-Ing Wang, Ting-Wei Liao, Jia-Hua Jhuo, Vivien Cheng   +13 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.

PLoS Pathogens, 2012
Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC/C ...
David S Guttery, David J P Ferguson, Benoit Poulin, Zhengyao Xu, Ursula Straschil, Onny Klop, Lev Solyakov, Sara M Sandrini, Declan Brady, Conrad A Nieduszynski, Chris J Janse, Anthony A Holder, Andrew B Tobin, Rita Tewari   +13 more
doaj   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Catalytic Assembly of the Mitotic Checkpoint Inhibitor BubR1-Cdc20 by a Mad2-Induced Functional Switch in Cdc20

Molecular Cell, 2013
The mitotic checkpoint acts to maintain chromosome content by generation of a diffusible anaphase inhibitor. Unattached kinetochores catalyze a conformational shift in Mad2, converting an inactive open form into a closed form that can capture Cdc20, the mitotic activator of the APC/C ubiquitin ligase.
Han, Joo Seok, Holland, Andrew J., Fachinetti, Daniele, Kulukian, Anita, Cetin, Bulent, Cleveland, Don W.   +5 more
openaire   +2 more sources

Functional analysis of recurrent CDC20 promoter variants in human melanoma

Communications Biology, 2023
Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks.
Paula M. Godoy, Abimbola Oyedeji, Jacqueline L. Mudd, Vasilios A. Morikis, Anna P. Zarov, Gregory D. Longmore, Ryan C. Fields, Charles K. Kaufman   +7 more
doaj   +1 more source

Molecular Network Control Through Boolean Canalization [PDF]

, 2015
Boolean networks are an important class of computational models for molecular interaction networks. Boolean canalization, a type of hierarchical clustering of the inputs of a Boolean function, has been extensively studied in the context of network ...
Dimitrova, Elena S., Murrugarra, David
core   +3 more sources

Disengaging the Engine: Histone Deacetylases 1 and 2‐Mediated Acetylation of Hexokinase‐2 Regulates Energy Metabolism in Microglia Following Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study demonstrates that HDAC1/2 knockout in microglia alleviates neurological deficits, preserves white matter, and accelerates hematoma clearance after ICH. HDAC1/2 inhibition reduces HK2 acetylation, shifts metabolism from glycolysis to fatty acid oxidation, reduces inflammation, and enhances phagocytosis.
Zhiwen Jiang, Heng Yang, Xinjie Gao, Zengyu Zhang, Ruiyuan Weng, Yuchao Fei, Jiabin Su, Hanqiang Jiang, Wei Ni, Yuxiang Gu   +9 more
wiley   +1 more source

Doing the CDC20 shuffle

The Journal of Cell Biology, 2003
![][1] Without Cks1 (filled squares), CDC20 expression is flat. May/Macmillan For perhaps a decade, Suc1 was the hardy little protein that featured in almost every cell cycle paper. But it was used only as a reagent—its binding to cyclin-dependent kinases (such as Cdc2 or Cdc28)
openaire   +2 more sources

High Expression Levels of CDK1 and CDC20 in Patients With Lung Squamous Cell Carcinoma are Associated With Worse Prognosis

Frontiers in Molecular Biosciences, 2021
Purpose: Progress related to the early detection and molecular targeted therapy of lung squamous cell carcinoma (LUSC) remains limited. The goal of our study was to identify key candidate indicators of LUSC.Methods: Three microarray datasets (GSE33532 ...
Huan Deng, Huan Deng, Huan Deng, Huan Deng, Qingqing Hang, Dijian Shen, Dijian Shen, Dijian Shen, Hangjie Ying, Hangjie Ying, Hangjie Ying, Yibi Zhang, Xu Qian, Xu Qian, Xu Qian, Ming Chen, Ming Chen, Ming Chen   +17 more
doaj   +1 more source