Results 71 to 80 of about 20,500 (223)

The Arabidopsis BUB1/MAD3 family protein BMF3 requires BUB3.3 to recruit CDC20 to kinetochores in spindle assembly checkpoint signaling

Proceedings of the National Academy of Sciences of the United States of America
Significance Mitotic progression into anaphase is monitored by the spindle assembly checkpoint that is poorly understood in plants. Using Arabidopsis thaliana as a model system, we identified an interaction pattern centered at the BUB1 and MAD3 protein ...
Xingguang Deng, F. Peng, Xiaoya Tang, Y. Lee, Honghui Lin, Bo Liu   +5 more
semanticscholar   +1 more source

The Prognostic Assessment of CDC20 in Patients with Renal Clear Cell Carcinoma and Its Relationship with Body Immunity

Contrast Media & Molecular Imaging, 2022
This article analyzes the relationship between cell division cycle (CDC20) molecules and oncology outcomes in patients with renal clear cell carcinoma (KIRC).
Jiaqi Shi, Yinhao Chen, Xiameng Gu, Xuerong Wang, Jing Liu, Xiaolan Chen   +5 more
semanticscholar   +1 more source

Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint

Cell Division, 2007
During mitosis, the genome duplicated during S-phase is synchronously and accurately segregated to the two daughter cells. The spindle checkpoint prevents premature sister-chromatid separation and mitotic exit.
Yu Hongtao, Díaz-Martínez Laura A
doaj   +1 more source

The Mitotic Checkpoint Complex controls the association of Cdc20 regulatory protein with the ubiquitin ligase APC/C in mitosis

Proceedings of the National Academy of Sciences of the United States of America
Significance Cdc20 is involved in both positive and negative regulation of the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C) at different stages of mitosis.
Danielle Sitry-Shevah, Shirly Miniowitz-Shemtov, Tanya Liburkin Dan, A. Hershko   +3 more
semanticscholar   +1 more source

Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk [PDF]

, 2011
During meiosis, one round of deoxyribonucleic acid replication is followed by two rounds of nuclear division. In Saccharomyces cerevisiae, activation of the Cdc14 early anaphase release (FEAR) network is required for exit from meiosis I but does not lead
Arumugam, Prakash, Kerr, Gary W., Millar, Jonathan B. A., Petronczki, Mark, Sarkar, Sourav, Tibbles, Katherine L.   +5 more
core   +3 more sources

Targeting APC/CCDC20 by Pro-TAME Suppresses Tumor Proliferation and Induces Apoptosis in Endometrial Carcinoma

Clinical and Experimental Obstetrics & Gynecology
Background: Anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that recruits substrates for ubiquitination and subsequent degradation.
Fang Fang, Ke Ni
doaj   +1 more source

High Expression Levels of CDK1 and CDC20 in Patients With Lung Squamous Cell Carcinoma are Associated With Worse Prognosis

Frontiers in Molecular Biosciences, 2021
Purpose: Progress related to the early detection and molecular targeted therapy of lung squamous cell carcinoma (LUSC) remains limited. The goal of our study was to identify key candidate indicators of LUSC.Methods: Three microarray datasets (GSE33532 ...
Huan Deng, Huan Deng, Huan Deng, Huan Deng, Qingqing Hang, Dijian Shen, Dijian Shen, Dijian Shen, Hangjie Ying, Hangjie Ying, Hangjie Ying, Yibi Zhang, Xu Qian, Xu Qian, Xu Qian, Ming Chen, Ming Chen, Ming Chen   +17 more
doaj   +1 more source

High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors. [PDF]

EMBO Rep
Spindle assembly checkpoint (SAC) inhibitors are a recently developed class of drugs, which perturb chromosome segregation during cell division, induce chromosomal instability (CIN), and eventually lead to cell death.
Zheng S, Raz L, Zhou L, Cohen-Sharir Y, Tian R, Ippolito MR, Gianotti S, Saad R, Wardenaar R, Broekhuis M, Suarez Peredo Rodriguez M, Wobben S, van den Brink A, Bakker P, Santaguida S, Foijer F, Ben-David U, Ben-David U.   +17 more
europepmc   +2 more sources

The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation [PDF]

, 2005
Deciphering regulatory events that drive malignant transformation represents a major challenge for systems biology. Here we analyzed genome-wide transcription profiling of an in-vitro transformation process.
Assif Yitzhaky, Badie C, Barrett MT, Blatt M, Eytan Domany, Halfon MS, Hoffman WH, Igor Shats, Mantovani R, Michael Milyavsky, Milyavsky M, Or Zuk, Ran Brosh, Roberto Mantovani, Varda Rotter, Yitzhak Pilpel, Yuval Tabach, Zhou X   +17 more
core   +3 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source