Design, Synthesis, and Biological Evaluation of Apcin-Based CDC20 Inhibitors.
ACS Medicinal Chemistry Letters, 2022 CDC20 binds to anaphase-promoting complex/cyclosome E3 ubiquitin ligase to recruit substrates for ubiquitination to promote mitotic progression. In breast and other cancers, CDC20 overexpression causes cell cycle dysregulation and is associated with poor
R. Bhuniya +7 more
semanticscholar +1 more source
The meiosis-specific Cdc20 family-member Ama1 promotes binding of the Ssp2 activator to the Smk1 MAP kinase. [PDF]
, 2018 Smk1 is a meiosis-specific MAP kinase (MAPK) in budding yeast that is required for spore formation. It is localized to prospore membranes (PSMs), the structures that engulf haploid cells during meiosis II (MII).
Diamond, Aviva +5 more
core +3 more sources
REC8 inhibits proliferation, migration and invasion of breast cancer cells by targeting CDC20
Molecular Medicine Reports, 2022 Breast cancer is one of the most types of common malignant tumor in women. REC8 is a known tumor suppressor in several types of cancer; however, the role of REC8 in breast cancer remains unknown.
Shaodan He, Danping Liu, Zhuanhong Chen
semanticscholar +1 more source
Peptide inhibitors of the anaphase promoting-complex that cause sensitivity to microtubule poison. [PDF]
PLoS ONE, 2018 There is an interest in identifying Anaphase Promoting-Complex/Cyclosome (APC/C) inhibitors that lead to sensitivity to microtubule poisons as a strategy for targeting cancer cells.
Scott C Schuyler +13 more
doaj +1 more source
The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation [PDF]
, 2005 Deciphering regulatory events that drive malignant transformation represents a major challenge for systems biology. Here we analyzed genome-wide transcription profiling of an in-vitro transformation process.
Assif Yitzhaky +17 more
core +3 more sources
Molecular Cell, 2013 The mitotic checkpoint acts to maintain chromosome content by generation of a diffusible anaphase inhibitor. Unattached kinetochores catalyze a conformational shift in Mad2, converting an inactive open form into a closed form that can capture Cdc20, the mitotic activator of the APC/C ubiquitin ligase.
Han, Joo Seok +5 more
openaire +2 more sources
Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint
Cell Division, 2007 During mitosis, the genome duplicated during S-phase is synchronously and accurately segregated to the two daughter cells. The spindle checkpoint prevents premature sister-chromatid separation and mitotic exit.
Yu Hongtao, Díaz-Martínez Laura A
doaj +1 more source
Meiotic nuclear divisions in budding yeast require PP2ACdc55-mediated antagonism of Net1 phosphorylation by Cdk [PDF]
, 2011 During meiosis, one round of deoxyribonucleic acid replication is followed by two rounds of nuclear division. In Saccharomyces cerevisiae, activation of the Cdc14 early anaphase release (FEAR) network is required for exit from meiosis I but does not lead
Arumugam, Prakash +5 more
core +3 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of AmericaSignificance Mitotic progression into anaphase is monitored by the spindle assembly checkpoint that is poorly understood in plants. Using Arabidopsis thaliana as a model system, we identified an interaction pattern centered at the BUB1 and MAD3 protein ...
Xingguang Deng +5 more
semanticscholar +1 more source