Results 81 to 90 of about 20,500 (223)
Molecular Network Control Through Boolean Canalization [PDF]
, 2015 Boolean networks are an important class of computational models for molecular interaction networks. Boolean canalization, a type of hierarchical clustering of the inputs of a Boolean function, has been extensively studied in the context of network ...
Dimitrova, Elena S., Murrugarra, David
core +3 more sources
Advanced Healthcare Materials, EarlyView.Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel +13 more
wiley +1 more source
Aging, 2022 Infection virus including HBV and HCV has been well recognized as a major cause inducing hepatocellular carcinoma (HCC). However, molecular investigations into the HTLV-1 (Human T-lymphotropic virus type-1) and HCC have been rare.
Juanni Li +3 more
semanticscholar +1 more source
A Method to Identify and Analyze Biological Programs through Automated Reasoning. [PDF]
, 2016 Predictive biology is elusive because rigorous, data-constrained, mechanistic models of complex biological systems are difficult to derive and validate.
and Stephen Emmott, 5 +5 more
core +1 more source
CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation
Advanced Science, EarlyView.Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao +18 more
wiley +1 more source
A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores
Science, 2021 Checking fidelity in cell division Everything has to go right during cell division, so a checkpoint mechanism known as the spindle-assembly checkpoint prevents mitosis from proceeding unless the kinetochores that attach chromosomes to the spindle ...
Pablo Lara-Gonzalez +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.Clathrin Light Chain B (CLTB) drives hepatocellular carcinoma progression through dual pathways: intracellularly, it activates the NF‐κB–PCLAF axis to enhance small extracellular vesicle (sEV) uptake and tumor proliferation; extracellularly, CLTB‐enriched sEVs bind SH3KBP1 to inhibit its degradation, inducing angiogenesis and vascular leakage ...
Xiaoke Sun +7 more
wiley +1 more source
Conserved CDC20 cell cycle functions are carried out by two of the five isoforms in Arabidopsis thaliana. [PDF]
PLoS ONE, 2011 The CDC20 and Cdh1/CCS52 proteins are substrate determinants and activators of the Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligase and as such they control the mitotic cell cycle by targeting the degradation of various cell cycle ...
Zoltán Kevei +7 more
doaj +1 more source
Securin Is Not Required for Chromosomal Stability in Human Cells [PDF]
, 2005 Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human cells are therefore of great interest.
Azofeifa +32 more
core +4 more sources
Advanced Science, EarlyView.This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang +13 more
wiley +1 more source