Results 41 to 50 of about 4,383 (155)
Construction of Large‐Scale Bioengineered Hair Germs and In Vivo Transplantation
Advanced Science, EarlyView.Here, a novel bioengineered hair germ (BHG) system is developed using thermodynamically incompatible mucopolysaccharides for efficient hair follicle regeneration. The BHG microspheres, produced via microfluidic technology, encapsulate Wnt3a for sustained release, enhancing mesenchymal stem cell differentiation and activating key regeneration pathways ...
Yangpeng Chen +8 more
wiley +1 more source
Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer
Advanced Science, EarlyView.Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng +8 more
wiley +1 more source
Effects of cdc42 gene knockout by CRISPR/Cas9 technology on osteochondral development in zebrafish
陆军军医大学学报Objective To knock out cdc42 gene in zebrafish using CRISPR/Cas9 technology, and investigate the effect of cdc42 on early osteochondral development.
YANG Yunfei, LI Yi, SUN Xianding
doaj +1 more source
Cells, 2019 : T cell activation is immediately followed by internalization of the T cell receptor (TCR). TCR endocytosis is required for T cell activation, but the mechanisms supporting removal of TCR from the cell surface remain incompletely understood.
Pascal Rossatti +5 more
doaj +1 more source
Advanced Science, EarlyView.This study develops RPTH by re‐modifying teriparatide and designs a biomimetic microstructured scaffold (BMRP) loaded with RPTH to address osteoporotic tendon‐to‐bone interface repair. The BMRP restores tissue architecture by balancing bone homeostasis and remodeling the microstructure, achieving functional recovery in an osteoporotic rotator cuff tear
Chengzhong Xu +11 more
wiley +1 more source
Chronic inflammation evoked by pathogenic stimulus during carcinogenesis
4 open, 2019 A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
Targeting Rac and Cdc42 GEFs in Metastatic Cancer
Frontiers in Cell and Developmental Biology, 2020 The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin cytoskeletal rearrangements; and thus, cell growth, migration/invasion, polarity, and adhesion.
Maria del Mar Maldonado +3 more
doaj +1 more source
Relation of CDC42, Th1, Th2, and Th17 cells with cognitive function decline in Alzheimer's disease
Annals of Clinical and Translational Neurology, 2022 Objective Cell division cycle 42 (CDC42) regulates neurite outgrowth, neurotransmitter, and T help (Th) cell‐mediated neuroinflammation, while its clinical implication in Alzheimer's disease (AD) is not clear.
Yi Zhang, Chenglin Niu
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Phenotypic Expansion of Knobloch Syndrome Type 2 in an Individual With a De Novo PAK2 Variant
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT P21‐activated kinase 2 (PAK2) is a serine/threonine kinase essential for a variety of cellular processes including signal transduction, cellular survival, proliferation, and migration. A recent report proposed monoallelic PAK2 variants cause Knobloch syndrome type 2 (KNO2)—a developmental disorder primarily characterized by ocular anomalies ...
Elizabeth A. Werren +10 more
wiley +1 more source
Negative regulation of CDC42 expression and cell cycle progression by miR-29a in breast cancer
Open Medicine, 2016 The inhibitory role of microRNA-29a (miR-29a) has been assessed in breast cancer cells. Herein, we analyze the underlying mechanisms of its role in cell cycle progression in breast cancer cells.
Zhang Mingliang +3 more
doaj +1 more source