Results 41 to 50 of about 75,568 (261)
Frontiers in Microbiology, 2021 Hepatitis E Virus (HEV) causes viral hepatitis in humans worldwide, while a subset of HEV species, avian HEV, causes hepatitis-splenomegaly syndrome in chickens.
Mengnan Fan +10 more
doaj +1 more source
The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility [PDF]
, 2013 Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs).
Alberts +79 more
core +2 more sources
Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected [PDF]
, 2004 Polycystin-1, the polycystic kidney disease 1 gene product, has been implicated in several signaling complexes that are known to regulate essential cellular functions. We investigated the role of polycystin-1 in Wnt signaling and activator protein-1 (
Arnould +37 more
core +3 more sources
Rho GTPases and their downstream effectors in megakaryocyte biology
Platelets, 2019 Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo ...
Irina Pleines +2 more
doaj +1 more source
Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting. [PDF]
PLoS ONE, 2012 The ras proto-oncogene is one of the most frequently mutated genes in human cancer. However, given the prevalence of activating mutations in Ras and its association with aggressive forms of cancer, attempts to therapeutically target aberrant Ras ...
Kristy R Stengel, Yi Zheng
doaj +1 more source
Molecular subversion of Cdc42 signalling in cancer [PDF]
Biochemical Society Transactions, 2021 Cdc42 is a member of the Rho family of small GTPases and a master regulator of the actin cytoskeleton, controlling cell motility, polarity and cell cycle progression. This small G protein and its regulators have been the subject of many years of fruitful investigation and the advent of functional genomics and proteomics has opened up new avenues of ...
Murphy, Natasha P +3 more
openaire +2 more sources
Cell-cell and cell-matrix adhesion in survival and metastasis: Stat3 versus Akt
Biomolecular Concepts, 2015 Both cell-cell and cell-matrix adhesion are important for epithelial cell differentiation and function. Classical cadherins mediate cell to cell interactions and are potent activators of the signal transducer and activator of transcription (Stat3 ...
Niit Maximilian +6 more
doaj +1 more source
Inhibition of Cdc42 during mitotic exit is required for cytokinesis [PDF]
, 2014 The role of Cdc42 and its regulation during cytokinesis is not well understood. Using biochemical and imaging approaches in budding yeast, we demonstrate that Cdc42 activation peaks during the G1/S transition and during anaphase but drops during mitotic ...
Atkins, Benjamin D. +5 more
core +1 more source
Cdc42 - the centre of polarity [PDF]
Journal of Cell Science, 2004 All cell types polarize, at least transiently, during division or to generate specialized shapes and functions. This capacity extends from yeast to mammals, and it is now clear that many features of the molecular mechanisms controlling polarization are conserved in all eukaryotic cells.
openaire +2 more sources
Cdc42-Mediated Tubulogenesis Controls Cell Specification [PDF]
Cell, 2009 Understanding how cells polarize and coordinate tubulogenesis during organ formation is a central question in biology. Tubulogenesis often coincides with cell-lineage specification during organ development. Hence, an elementary question is whether these two processes are independently controlled, or whether proper cell specification depends on ...
Kesavan, Gokul +7 more
openaire +4 more sources