Results 41 to 50 of about 86,770 (308)

CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity [PDF]

Glia
CDC42‐effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin‐dependent scaffolding of myelin. Myelin outfoldings do not cause secondary neuropathology per se. ABSTRACT The regular structure of CNS myelin requires specialized structural proteins, including septin ...
Hümmert S, de Faria J, Jahn O, Bilgin E, Łukasik N, Rao C, Mitkovski M, Benseler F, Brose N, Siems S, Goebbels S, Möbius W, Ewers H, Relvas J, Werner H.   +14 more
europepmc   +2 more sources

Cdc42 Oscillations in Yeasts

Science Signaling, 2012
Oscillations in the localization of active Cdc42 govern polarized cell growth in yeasts.
Bendezu, F. O., Martin, S. G.
openaire   +2 more sources

The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms [PDF]

, 2008
© 2008 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Ammerer G., Andoh T., Bose I., Bosl W. J., Bourmeyster N., Christopher Tiedje, Chuang T. H., Cole K. C., Daniel Lew, DerMardirossian C., DerMardirossian C., Dovas A., Dransart E., Eitzen G., Forget M. A., Gladfelter A. S., Gulli M. P., Hoffman G. R., Höfken T., Höfken T., Imme Sakwa, Irazoqui J. E., Irazoqui J. E., Jaffe A. B., Janke C., Jensen S., Kassir Y., Kim L., Knop M., Koch G., Lee D. H., Longtine M. S., Marco E., Masuda T., Mazón M. J., Mehta D., Mösch H. U., Nomanbhoy T. K., Palecek S. P., Park H. O., Ptacek J., Richman T. J., Richman T. J., Roberts R. L., Roth A. F., Rotin D., Scheffzek K., Schwamborn J. C., Seshan A., Takahashi K., Tcheperegine S. E., Thomas Höfken, Ursula Just, Valdez-Taubas J., Wang H. R., Wedlich-Soldner R., Yamashita T., Yamochi W., Ziman M.   +58 more
core   +3 more sources

Cell Division Control Protein 42 Interacts With Hepatitis E Virus Capsid Protein and Participates in Hepatitis E Virus Infection

Frontiers in Microbiology, 2021
Hepatitis E Virus (HEV) causes viral hepatitis in humans worldwide, while a subset of HEV species, avian HEV, causes hepatitis-splenomegaly syndrome in chickens.
Mengnan Fan, Yuhang Luo, Beibei Zhang, Jiaxi Wang, Tianxiang Chen, Baoyuan Liu, Yani Sun, Yuchen Nan, Julian A. Hiscox, Qin Zhao, En-Min Zhou   +10 more
doaj   +1 more source

The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility [PDF]

, 2013
Vaccinia virus dissemination relies on the N-WASP– ARP2/3 pathway, which mediates actin tail formation underneath cell-associated extracellular viruses (CEVs).
Alberts, Alvarez, Arakawa, Bagrodia, Bernardini, Block, Boujemaa-Paterski, Chong, Chong, Diego E. Alvarez, Earl, Engelstad, Feig, Frischknecht, Fukuoka, Gasteier, Goldberg, Haglund, Hannemann, Harris, Harris, Heindl, Hervé Agaisse, Hiller, Hollinshead, Hoppe, Humphries, Isaacs, Katz, Kleba, Koka, Kovar, Krall, Lammers, Lasa, Li, Madrid, Moseley, Moseley, Newsome, Newsome, Nezami, Otomo, Parkinson, Pollard, Pring, Pruyne, Qiu, Ridley, Rietdorf, Roberts, Rolls, Romero, Röttger, Sanderson, Scaplehorn, Schmelz, Schulte, Schönichen, Schönichen, Serio, Shibata, Siripala, Skoble, Smith, Suzuki, Takeya, Tooze, van Eijl, van Eijl, Wallar, Ward, Ward, Watanabe, Weisswange, Welch, Westendorf, Westendorf, Wolffe, Wolffe   +79 more
core   +2 more sources

Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting. [PDF]

PLoS ONE, 2012
The ras proto-oncogene is one of the most frequently mutated genes in human cancer. However, given the prevalence of activating mutations in Ras and its association with aggressive forms of cancer, attempts to therapeutically target aberrant Ras ...
Kristy R Stengel, Yi Zheng
doaj   +1 more source

Molecular subversion of Cdc42 signalling in cancer [PDF]

Biochemical Society Transactions, 2021
Cdc42 is a member of the Rho family of small GTPases and a master regulator of the actin cytoskeleton, controlling cell motility, polarity and cell cycle progression. This small G protein and its regulators have been the subject of many years of fruitful investigation and the advent of functional genomics and proteomics has opened up new avenues of ...
Murphy, Natasha P, Binti Ahmad Mokhtar, Ana Masara, Mott, Helen R, Owen, Darerca   +3 more
openaire   +2 more sources

Rho GTPases and their downstream effectors in megakaryocyte biology

Platelets, 2019
Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo ...
Irina Pleines, Deya Cherpokova, Markus Bender   +2 more
doaj   +1 more source

CDC42-mediated Wnt signaling facilitates odontogenic differentiation of DPCs during tooth root elongation

Stem Cell Research & Therapy, 2023
Background CDC42 is a member of Rho GTPase family, acting as a molecular switch to regulate cytoskeleton organization and junction maturation of epithelium in organ development.
Tao Zhou, Guoqing Chen, Yuchan Xu, Shuning Zhang, Huilin Tang, Tao Qiu, Weihua Guo   +6 more
doaj   +1 more source

Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases

International Journal of Molecular Sciences, 2019
Cdc42, a member of the Rho GTPases family, is involved in the regulation of several cellular functions including cell cycle progression, survival, transcription, actin cytoskeleton organization and membrane trafficking.
Qi-Yuan Huang, Xing-Ning Lai, X. Qian, Lin-Chen Lv, Jun Li, Jing Duan, Xing-Hua Xiao, Li-Xia Xiong   +7 more
semanticscholar   +1 more source