Results 41 to 50 of about 6,449 (175)

Abnormal expression of lysosomal glycoproteins in patients with congenital disorders of glycosylation

BMC Research Notes, 2023
Objective The study of the impact of some inherited defects in glycosylation on the biosynthesis of some lysosomal glycoproteins. Results description: Whole-exome sequencing revealed a homozygous variant; 428G > A; p. (R143K) in SRD5A3 in one patient and
Sahar Sabry, Noura R. Eissa, Maha S. Zaki   +2 more
doaj   +1 more source

Relaxivity of Gadobutrol and Gadoteric Acid in Cerebrospinal Fluid at 3T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose The aim was to estimate T1 relaxivity of gadobutrol and gadoteric acid in cerebrospinal fluid (CSF) at 3T, to support research on CSF‐flow and the glymphatic system in humans utilizing T1 mapping after intrathecal injection. Methods Using a phantom, relaxivity was estimated for gadobutrol and gadoteric acid in lumbar CSF and an ...
Sofia Behndig, Anders Garpebring, Daniel Dahlgren Lindström, Jan Malm, Anders Wåhlin, Anders Eklund   +5 more
wiley   +1 more source

Cyclic-di-GMP Induces STING-Dependent ILC2 to ILC1 Shift During Innate Type 2 Lung Inflammation

Frontiers in Immunology, 2021
Type 2 inflammation is found in most forms of asthma, which may co-exist with recurrent viral infections, bacterial colonization, and host cell death.
Kellen J. Cavagnero, Kellen J. Cavagnero, Jana H. Badrani, Luay H. Naji, Michael B. Amadeo, Anthea S. Leng, Lee Diego Lacasa, Allyssa N. Strohm, Samantha R. Renusch, Suzanna S. Gasparian, Taylor A. Doherty, Taylor A. Doherty   +11 more
doaj   +1 more source

The effects of single versus successive warm summers on an intertidal community

Oikos, EarlyView.
To accurately predict how organisms and ecological communities will respond to future conditions caused by climate change, we must consider the temporal dynamics of environmental stressors, including the effects of repeated exposures to stress. We performed a two‐year passive thermal manipulation in coastal British Columbia, Canada to determine how ...
Amelia V. Hesketh, Cassandra A. Konecny, Sandra M. Emry, Christopher D. G. Harley   +3 more
wiley   +1 more source

The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo

eLife, 2015
Effective mucosal adjuvants enhance the magnitude and quality of the vaccine response. Cyclic di-GMP (CDG) is a promising mucosal vaccine adjuvant. However, its in vivo mechanisms are unclear. Here, we showed, in mice, that CDG elicits stronger Ab and TH
Steven M Blaauboer, Samira Mansouri, Heidi R Tucker, Hatti L Wang, Vincent D Gabrielle, Lei Jin   +5 more
doaj   +1 more source

Vascular ring anomaly in a patient with phosphomannomutase 2 deficiency: A case report and review of the literature

JIMD Reports, 2020
Background Congenital disorders of glycosylation (CDG) are a group of metabolic disorders well known to be associated with developmental delay and central nervous system anomalies.
Zhen Qian, Jef Van den Eynde, Stephane Heymans, Luc Mertens, Eva Morava   +4 more
doaj   +1 more source

Repositories of biocultural diversity: Toward best practices for empowering ethnobotany in digital herbaria

PLANTS, PEOPLE, PLANET, EarlyView.
Societal Impact Statement As herbaria digitize millions of plant specimens, ethnobotanical information associated with them is becoming increasingly accessible. These biocultural data include plant uses, names, and/or management practices of Indigenous Peoples and Local Communities (IPLCs).
Robbie Hart, Viviane Fonseca‐Kruel, Eduardo Dalcin, Estevão da Silva Luís Alexandre, Matthew Pace, Michaela Schmull, Leonardo Beltran‐Rodríguez, Miguel Murguía‐Romero, Diana G. Flores‐Camargo, Cristina Mapes‐Sánchez, Mark Nesbitt, Carolina Romero, Andrew Townesmith, Jan Salick, Alex McAlvay, Kenneth R. Otero‐Walker, Michael J. Balick, Jacob Golan, Bruce Hoffman, Kelsey Leonard, Giulia Mattalia, Guillaume Odonne, Aurora Prehn, Ina Vandebroek   +23 more
wiley   +1 more source

Alteration of Phase Transformation Behavior and Prior Austenite Grain Structure Due to Elevated Tramp Element Concentrations in a Hypoeutectoid Steel

steel research international, EarlyView.
The phase transformation behavior of a hypoeutectoid steel is studied in comparison with alloys containing higher concentrations of tramp elements, simulating high recycling rates. The examination of microstructures reveals that the tramp elements facilitate the formation of displacive phases along with retained austenite.
Lukas Hatzenbichler, Marek Gocnik, Phillip Haslberger, Matthew Galler, Andreas Stark, Oleksandr Glushko, Jozef Keckes, Ronald Schnitzer   +7 more
wiley   +1 more source

New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice

Frontiers in Immunology, 2020
Cyclic dinucleotides (CDNs) are promising vaccine adjuvants inducing balanced, potent humoral, and cellular immune responses. How aging influences CDN efficacy is unclear.
Himanshu Gogoi, Samira Mansouri, Divya S. Katikaneni, Lei Jin   +3 more
doaj   +1 more source

Investigation of Microscopic Nonmetallic Inclusions in Powder Metallurgical High‐Speed Steels

steel research international, EarlyView.
Methods for inclusion analysis are evaluated for suitability. Various powder metallurgical steels in different processing states are characterized. SEM/EDS data are further analyzed using analytical and statistical approaches. A thermodynamic method for determining inclusion phase composition is tested.
Manuel Schickbichler, Robert Musi, Martin Hafok, Christoph Turk, Gerald Schneeberger, Susanne Michelic   +5 more
wiley   +1 more source