Results 71 to 80 of about 6,449 (175)

A Heavy‐Duty Vehicle Routing Problem With Temperature Constraints

Networks, Volume 87, Issue 2, Page 131-150, March 2026.
ABSTRACT This article studies a vehicle routing problem involving a fleet of heavy‐duty vehicles and pickup‐and‐delivery requests for crude items that are both heavy and high‐temperature. The objective is to route the fleet in such a way that maximizes resource efficiency and operational efficiency while simultaneously avoiding thermal overload of any ...
Biljana Roljić, Yuan Chen
wiley   +1 more source

Quantifying the Impacts of the May 2024 Geomagnetic Storm on Transatlantic Aviation: Rerouting, Delays, and Economic Losses

Space Weather, Volume 24, Issue 3, March 2026.
Abstract The May 2024 geomagnetic storm, one of the most intense events of Solar Cycle 25 to date, caused widespread disruptions in aviation operations, particularly for polar and high‐latitude routes. This study quantifies the operational and economic impacts of the storm on 12 selected transatlantic flights between North America and Europe.
Jie Li, Xiaojian Hu, Dabin Xue, Zhizhao Liu, Qing‐He Zhang, Xueshang Feng   +5 more
wiley   +1 more source

Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG

Disease Models & Mechanisms, 2019
Phosphomannomutase 2 deficiency, or PMM2-CDG, is the most common congenital disorder of glycosylation and affects over 1000 patients globally. There are no approved drugs that treat the symptoms or root cause of PMM2-CDG.
Sangeetha Iyer, Feba S. Sam, Nina DiPrimio, Graeme Preston, Jan Verheijen, Kausalya Murthy, Zachary Parton, Hillary Tsang, Jessica Lao, Eva Morava, Ethan O. Perlstein   +10 more
doaj   +1 more source

Effectiveness of In‐Person Versus Online Psychoeducational Interventions With Divorced/Separated Parents: A Comparative Analysis

Family Process, Volume 65, Issue 1, March 2026.
ABSTRACT The dissolution of marriage frequently results in parental distress, strained coparental relationships, and adverse effects on children. Psychoeducational interventions have the potential to mitigate these effects, but there is a paucity of research exploring their comparative efficacy in in‐person versus online formats. The present study aims
Ángela Ordóñez‐Carabaño, Pilar Martínez‐Díaz, Mª. Angustias Roldán Franco, Virginia Cagigal de Gregorio   +3 more
wiley   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, Volume 293, Issue 6, Page 1681-1707, March 2026.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Influence of cement content on constitutive model parameters of reinforced completely decomposed granite soil

Shenzhen Daxue xuebao. Ligong ban
Completely decomposed granite (CDG) is widely distributed throughout the South China. Due to its tendency to soften and disintegrate upon contact with water, the post-grouting method is employed in some engineering projects to reinforce the soil around ...
MA Deshan, ZHANG Dong, TANG Rui, LIU Fei, JIAO Jingzhi, LIU Shaowen, SU Dong   +6 more
doaj   +1 more source

Evaluation of the effects of Chinese Dietary Guidelines on nutrition, environment, and cost

Chinese Journal of Population, Resources and Environment
National dietary guidelines serve as a strategic tool to facilitate dietary adjustments, improve human nutrition, and reduce environmental strain by guiding individuals toward healthier dietary choices.
Shunan Zhao, Rui Li, Meng Li, Yanan Wang, Juan Wang, Rong Yuan   +5 more
doaj   +1 more source

A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential therapeutics for the rare disease DPAGT1-CDG.

PLoS Genetics
DPAGT1-CDG is a Congenital Disorder of Glycosylation (CDG) that lacks effective therapies. It is caused by mutations in the gene DPAGT1 which encodes the first enzyme in N-linked glycosylation.
Hans M Dalton, Naomi J Young, Alexys R Berman, Heather D Evans, Sydney J Peterson, Kaylee A Patterson, Clement Y Chow   +6 more
doaj   +1 more source

Clinical and Molecular Features of Patients With Congenital Disorders of Glycosylation in Japan

JIMD Reports
Congenital disorders of glycosylation (CDG) are a heterogeneous group of diseases caused by defects in various steps of the glycosylation pathway. There are over 200 known human glycosylation‐related disorders. Many of these defects lead to multisystemic
Nobuhiko Okamoto, Machiko Kadoya, Yoshinao Wada   +2 more
doaj   +1 more source

Candidate Dark Galaxy-2: Validation and Analysis of an Almost Dark Galaxy in the Perseus Cluster

The Astrophysical Journal Letters
Candidate Dark Galaxy-2 (CDG-2) is a potential dark galaxy consisting of four globular clusters (GCs) in the Perseus cluster, first identified in D. Li et al. through a sophisticated statistical method. The method searched for overdensities of GCs from a
Dayi (David) Li, Qing Liu, Gwendolyn M. Eadie, Roberto G. Abraham, Francine R. Marleau, William E. Harris, Pieter van Dokkum, Aaron J. Romanowsky, Shany Danieli, Patrick E. Brown, Alex Stringer   +10 more
doaj   +1 more source