Results 71 to 80 of about 6,717 (197)

Real‐world‐data for phenotypes and genotypes of rare monogenic genetic epilepsies and genes of uncertain significance for epilepsy

Epilepsia Open, Volume 11, Issue 4, Page 1184-1199, August 2026.
Abstract Objectives The objectives of this study were to develop a real‐world‐data (RWD) database for patients with epilepsy to provide further real‐world‐evidence (RWE) for monogenic genetic epilepsies; to assess the usefulness of a diagnostic algorithm in epilepsy; and to examine protein 3D structures using in silico tools to predict variant ...
Haley Morris, Elizabeth Mathew, Shalini Bahl, Marta Villa‐Lopez, Saadet Mercimek‐Andrews   +4 more
wiley   +1 more source

Thioredoxin system modulates metabolic and stomatal responses to elevated CO2 in Arabidopsis

New Phytologist, Volume 251, Issue 4, Page 1774-1791, August 2026.
Integrative model of extraplastidial NADPH‐dependent thioredoxin reductase/thioredoxin system‐mediated regulation of stomatal function, redox homeostasis, and metabolic responses under ambient and elevated CO2 in Arabidopsis thaliana. Summary The NADPH‐dependent thioredoxin reductase/thioredoxin (NTR/TRX) system plays a central role in maintaining ...
Paula da Fonseca‐Pereira, Domingos F. Mélo Neto, Rita de Cássia Monteiro‐Batista, Daniel Gomes Coelho, Jaciara Lana‐Costa, Leonardo Perez de Souza, Ina Krahnert, Danilo M. Daloso, Jorge Gago, Alisdair R. Fernie, Wagner L. Araújo, Adriano Nunes‐Nesi   +11 more
wiley   +1 more source

Natural variation in OsMYB305 downregulating cytokinin‐mediated inhibition of leaf senescence contributes to regional adaptation in rice

New Phytologist, Volume 251, Issue 4, Page 1873-1888, August 2026.
Proposed regulatory model of OsMYB305 in leaf senescence. Summary Accumulating evidence has identified transcription factors (TFs) as key regulators of the onset and progression of leaf senescence. However, the regulatory role of the rice myeloblastosis (MYB) TF OsMYB305 in this process remains largely unknown.
Boyeong Kim, Jinah Kim, Yejin Shim, Jinku Kang, Hyeryung Yoon, Sung‐Hwan Cho, Nam‐Chon Paek, Kiyoon Kang   +7 more
wiley   +1 more source

Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG

Disease Models & Mechanisms, 2019
Phosphomannomutase 2 deficiency, or PMM2-CDG, is the most common congenital disorder of glycosylation and affects over 1000 patients globally. There are no approved drugs that treat the symptoms or root cause of PMM2-CDG.
Sangeetha Iyer, Feba S. Sam, Nina DiPrimio, Graeme Preston, Jan Verheijen, Kausalya Murthy, Zachary Parton, Hillary Tsang, Jessica Lao, Eva Morava, Ethan O. Perlstein   +10 more
doaj   +1 more source

A Global Review of Microplastic Contamination in Groundwater: Empirical Evidence and Latin American Perspectives

Water and Environment Journal, Volume 40, Issue 3, Page 357-366, August 2026.
ABSTRACT The presence of microplastics (MPs) in groundwater has emerged as a significant concern due to their environmental impact and the threat they pose to vital water resources, groundwater being one of the most important freshwater sources in the world.
Lara Luiza de Oliveira Pompermayer, Ana Dalva de Oliveira de Santos, Danieli Lima da Cunha, Joel de Matos Junior, Khauê Silva Vieira, Diego Gomes Carvalho, Christine Claire Gaylarde, José Antonio Baptista Neto   +7 more
wiley   +1 more source

Evaluation of the effects of Chinese Dietary Guidelines on nutrition, environment, and cost

Chinese Journal of Population, Resources and Environment
National dietary guidelines serve as a strategic tool to facilitate dietary adjustments, improve human nutrition, and reduce environmental strain by guiding individuals toward healthier dietary choices.
Shunan Zhao, Rui Li, Meng Li, Yanan Wang, Juan Wang, Rong Yuan   +5 more
doaj   +1 more source

Fine multidegrees, universal Gröbner bases, and matrix Schubert varieties

Journal of the London Mathematical Society, Volume 114, Issue 2, August 2026.
Abstract We give a criterion for a collection of polynomials to be a universal Gröbner basis for an ideal in terms of the multidegree of the closure of the corresponding affine variety in (P1)N$(\mathbb {P}^1)^N$. This criterion can be used to give simple proofs of several existing results on universal Gröbner bases.
Daoji Huang, Matt Larson
wiley   +1 more source

Influence of cement content on constitutive model parameters of reinforced completely decomposed granite soil

Shenzhen Daxue xuebao. Ligong ban
Completely decomposed granite (CDG) is widely distributed throughout the South China. Due to its tendency to soften and disintegrate upon contact with water, the post-grouting method is employed in some engineering projects to reinforce the soil around ...
MA Deshan, ZHANG Dong, TANG Rui, LIU Fei, JIAO Jingzhi, LIU Shaowen, SU Dong   +6 more
doaj   +1 more source

A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential therapeutics for the rare disease DPAGT1-CDG.

PLoS Genetics
DPAGT1-CDG is a Congenital Disorder of Glycosylation (CDG) that lacks effective therapies. It is caused by mutations in the gene DPAGT1 which encodes the first enzyme in N-linked glycosylation.
Hans M Dalton, Naomi J Young, Alexys R Berman, Heather D Evans, Sydney J Peterson, Kaylee A Patterson, Clement Y Chow   +6 more
doaj   +1 more source

Are viral vector-mediated therapies compatible with aberrant glycosylation?

Molecular Therapy: Methods & Clinical Development
The ability of adeno-associated viruses (AAVs) to transduce host cells relies on interactions with glycan moieties on the cellular surface.
I.J.J. Muffels, R. Budhraja, S. Radenkovic, R. Shah, A. Pandey, E. Morava, T. Kozicz   +6 more
doaj   +1 more source