Results 31 to 40 of about 495,534 (295)
Coopercuc: percursos de valorização dos recursos locais e de convivência com o Semiárido
Sustentabilidade em Debate, 2016 Dentro do contexto de apropriação discursiva da convivência com o semiárido brasileiro, a história e a evolução da experiência da Cooperativa Agropecuária Familiar de Canudos, Uauá e Curaçá (Coopercuc), BA, exemplificam a afirmação exitosa de eventos e ...
Chiara Gentile, Andrés Burgos
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Storehouse and sanctuary: the role of Brazil in world food security
Fronteiras: Journal of Social, Technological and Environmental Science, 2013 Natural endowments such as land availability, abundant water, fertile soils, and favorable climate combined with decreasing population growth place Brazil as the leading force in world food production.
James Augusto Pires Tiburcio +1 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Insights into the Structure of Dot@Rod and Dot@Octapod CdSe@CdS Heterostructures [PDF]
, 2015 CdSe@CdS dot@rods with diameter around 6 nm and length of either 20, 27, or 30 nm and dot@octapods with pod diameters of ?15 nm and lengths of ?50 nm were investigated by X-ray absorption spectroscopy.
Anna Corrias +10 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Use of 6 Nucleotide Length Words to Study the Complexity of Gene Sequences from Different Organisms
Entropy, 2022 In this paper, we attempted to find a relation between bacteria living conditions and their genome algorithmic complexity. We developed a probabilistic mathematical method for the evaluation of k-words (6 bases length) occurrence irregularity in ...
Eugene Korotkov +2 more
doaj +1 more source
Complexation between oleanolic and maslinic acids with native and modified cyclodextrins [PDF]
, 2018 Oleanolic (OA) and maslinic (MA) acids are two natural triterpenoids with a wide range of beneficial effects for human health. However, their low solubility and permeability make their application in the food or industry difficult. The complexation of OA
López Miranda, Santiago
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source