Results 51 to 60 of about 207,846 (301)

Big issues for big data: challenges for critical spatial data analytics

Journal of Spatial Information Science, 2020
In this paper we consider some of the issues of working with big data and big spatial data and highlight the need for an open and critical framework. We focus on a set of challenges underlying the collection and analysis of big data.
Chris Brunsdon, Alexis Comber
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

The campaign for democratic socialism 1960-1964. [PDF]

, 1992
PhDIn early 1960 it seemed likely that the official Labour Party defence policy would be defeated by a unilateralist resolution at the Scarborough Conference.
Brivati, Leopoldo
core   +4 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Ilhas: o começo e o fim do mundo

Sustentabilidade em Debate, 2015
Steven Roger Fischer. Ilhas: de Atlântida a Zanzibar. São Paulo: Editora Unesp, 2014. 432p. [Tradução de Claudia Freire]. ISBN 978-85-393-0550-6. Preço: R$ 65,00. Inclui bibliografia, imagens e índice remissivo.
Marilia Teresinha de Sousa Machado
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Human Resource Management in Eritrea: Current and Future Trends [PDF]

, 2006
The CDS Research Report series publishes research papers, interesting working papers and pre-prints, as well as CDS seminar reports. The series includes papers of University of Groningen staff as well as of overseas partners who have participated in CDS ...
Fitsum Ghebregiorgis, Ghebregiorgis, F., Karsten, Luchien,, Luchien Karsten, Ghebregiorgis , Fitsum,, Karsten, Luchien   +5 more
core   +1 more source

Sociedade cabocla: participação e diversidade na Amazônia

Sustentabilidade em Debate, 2011
ADAMS, Cristina; MURRIETA, Rui; NEVES, Walter (Eds.). Sociedades caboclas amazônicas: modernidade e invisibilidade. São Paulo: Annablume, 2006. 364 p.; 16 X 23 cm. ISBN 85-7419-644-4.
Raquel Caribé Grando
doaj   +1 more source