Results 41 to 50 of about 492,468 (273)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

open access: yesFEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah   +8 more
wiley   +1 more source

Editorial

open access: yesRevista de Educação Física, 1964
[...]
CDS
doaj  

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer   +14 more
wiley   +1 more source

A mudança de comportamento como foco da análise energética

open access: yesSustentabilidade em Debate, 2015
Resenha escrita por Rebeca Roysen. Mestra em Psicologia Social (USP) e Doutoranda em Desenvolvimento Sustentável (UnB). Peters Fudge et al (eds.). The Global Challenge of Encouraging Sustainable Living: opportunities, barriers, policy and practice ...
Rebeca Roysen
doaj   +3 more sources

Ilhas: o começo e o fim do mundo

open access: yesSustentabilidade em Debate, 2015
Steven Roger Fischer. Ilhas: de Atlântida a Zanzibar. São Paulo: Editora Unesp, 2014. 432p. [Tradução de Claudia Freire]. ISBN 978-85-393-0550-6. Preço: R$ 65,00. Inclui bibliografia, imagens e índice remissivo.
Marilia Teresinha de Sousa Machado
doaj   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein   +13 more
wiley   +1 more source

Sociedade cabocla: participação e diversidade na Amazônia

open access: yesSustentabilidade em Debate, 2011
ADAMS, Cristina; MURRIETA, Rui; NEVES, Walter (Eds.). Sociedades caboclas amazônicas: modernidade e invisibilidade. São Paulo: Annablume, 2006. 364 p.; 16 X 23 cm. ISBN 85-7419-644-4.
Raquel Caribé Grando
doaj   +1 more source

Langevin Dynamics of the vortex matter two-stage melting transition in Bi_2Sr_2CaCu_2O$_{8+\delta}$ in the presence of straight and of tilted columnar defects

open access: yes, 2007
In this paper we use London Langevin molecular dynamics simulations to investigate the vortex matter melting transition in the highly anisotropic high-temperature superconductor material Bi_2Sr_2CaCu_2O$_{8+\delta}$ in the presence of low concentration ...
A. Buzdin   +5 more
core   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa   +10 more
wiley   +1 more source

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