Results 151 to 160 of about 6,157 (185)
Targeting the LIPH-CD36 axis potentiates CDK4/6 inhibition in ER+ breast cancer
Morandi A +20 more
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Regulation of DNA Replication Licensing and Re-Replication by Cdt1 [PDF]
International Journal of Molecular Sciences, 2021 In eukaryotic cells, DNA replication licensing is precisely regulated to ensure that the initiation of genomic DNA replication in S phase occurs once and only once for each mitotic cell division. A key regulatory mechanism by which DNA re-replication is suppressed is the S phase-dependent proteolysis of Cdt1, an essential replication protein for ...
Hui Zhang
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Regulation of Geminin and Cdt1 expression by E2F transcription factors [PDF]
Oncogene, 2004 Geminin and Cdt1 play an essential role in the initiation of DNA replication, by regulating the chromatin loading of the MCM complex. In this study, we showed that the transcription of human Geminin and Cdt1, as well as that of MCM7, is activated by transcription factors E2F1-4, but not by factors E2F5-7.
Kenichi Yoshida
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An Inactive Geminin Mutant That Binds Cdt1
Genes, 2015 The initiation of DNA replication is tightly regulated in order to ensure that the genome duplicates only once per cell cycle. In vertebrate cells, the unstable regulatory protein Geminin prevents a second round of DNA replication by inhibiting the essential replication factor Cdt1.
Benoit Miotto, Thomas J McGarry
exaly +4 more sources
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CDT1, a licensing factor that limits rereplication
Molecular Cell, 2023Cells must avoid licensing of neosynthesized DNA to prevent rereplication. In this issue of Molecular Cell, Ratnayeke et al. (2022)1 reveal how the licensing factor CDT1, prior to its degradation, inhibits DNA elongation by suppressing CMG helicase progression at replication forks.
Gergely, Rona, Michele, Pagano
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Geminin–Cdt1 balance is critical for genetic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005A cell limits its DNA replication activity to once per cell division cycle to maintain its genomic integrity. Studies in a variety of organisms are elucidating how these controls are exercised. Key amongst these is the regulation of replication initiator proteins such as Cdt1.
Anindya Dutta
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Oncogenic potential of the DNA replication licensing protein CDT1 [PDF]
Oncogene, 2002 The expression of a gene, designated as Retroviral insertion site (Ris)2, was activated by retroviral DNA integration in an immortalized primitive erythroid cell line, EB-PE. Ris2 was also expressed at high levels in all human tumor cell lines analysed.
Daved H. Fremont
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Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53 [PDF]
Oncogene, 2005 The exact duplication of chromosomal DNA during each cell cycle ensures the correct inheritance of genetic material from mother to daughter cells. In eukaryotic cells, DNA replication can occur only when the origin of DNA replication is accurately marked by a group of proteins termed licensing proteins.
Tej K Pandita, Girdhar G Sharma
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AbstractColorectal carcinoma (CRC) is one of the most common forms of malignancy in the Western world. Recent decades have witnessed enormous progress in our understanding of the mechanisms that sustain CRC, even though the factors implicated in the initiation and progression of this neoplasia are not fully understood.
Giovanni Monteleone, Carmine Stolfi
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Cdt1 and Geminin in DNA Replication Initiation
2012One of the mechanisms controlling the initiation of DNA replication is the dynamic interaction between Cdt1, which promotes assembly of the pre-replication license complex, and Geminin, which inhibits it. Specifically, Cdt1 cooperates with the cell cycle protein Cdc6 to promote loading of the minichromosome maintenance helicases (MCM) onto the ...
Christophe, Caillat +1 more
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