Results 131 to 140 of about 5,045 (159)

Cdt1 and Geminin in DNA Replication Initiation

2012
One of the mechanisms controlling the initiation of DNA replication is the dynamic interaction between Cdt1, which promotes assembly of the pre-replication license complex, and Geminin, which inhibits it. Specifically, Cdt1 cooperates with the cell cycle protein Cdc6 to promote loading of the minichromosome maintenance helicases (MCM) onto the ...
Christophe, Caillat, Anastassis, Perrakis   +1 more
openaire   +2 more sources

Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53 [PDF]

Oncogene, 2005
The exact duplication of chromosomal DNA during each cell cycle ensures the correct inheritance of genetic material from mother to daughter cells. In eukaryotic cells, DNA replication can occur only when the origin of DNA replication is accurately marked by a group of proteins termed licensing proteins.
Tej Pandita, Girdhar G Sharma, Pandita Tej K   +2 more
exaly   +3 more sources

Inhibition of Eukaryotic DNA Replication by Geminin Binding to Cdt1

Science, 2000
In all eukaryotic organisms, inappropriate firing of replication origins during the G 2 phase of the cell cycle is suppressed by cyclin-dependent kinases. Multicellular eukaryotes contain a second putative inhibitor of re-replication called geminin.
J A, Wohlschlegel, B T, Dwyer, S K, Dhar, C, Cvetic, J C, Walter, A, Dutta   +5 more
openaire   +2 more sources

Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis☆

Experimental Cell Research, 2004
Cdt1 is a conserved replication factor required in licensing the chromosome for a single round of DNA synthesis. The activity of Cdt1 is inhibited by geminin. The mechanism by which geminin interferes with Cdt1 activity is unknown. It is thought that geminin binds to and sequestrate Cdt1.
Domenico, Maiorano, Wilfrid, Rul, Marcel, Méchali   +2 more
openaire   +2 more sources

PCNA-Dependent Ubiquitination of Cdt1 and p21 in Mammalian Cells

2014
PCNA is a DNA clamp, acting on chromatin as a platform for various proteins involved in many aspects of DNA replication-linked processes. Most of these proteins have the PCNA-interaction protein motif (PIP box) that associates with PCNA. Recent works show that PCNA plays an important role as a matchmaker, connecting PCNA-interacting proteins to the ...
Akiyo, Hayashi, Naohiro, Suenaga, Yasushi, Shiomi, Hideo, Nishitani   +3 more
openaire   +2 more sources

The Cdt1 protein is required to license DNA for replication in fission yeast

Nature, 2000
To maintain genome stability in eukaryotic cells, DNA is licensed for replication only after the cell has completed mitosis, ensuring that DNA synthesis (S phase) occurs once every cell cycle. This licensing control is thought to require the protein Cdc6 (Cdc18 in fission yeast) as a mediator for association of minichromosome maintenance (MCM) proteins
H, Nishitani, Z, Lygerou, T, Nishimoto, P, Nurse   +3 more
openaire   +2 more sources

Development of stapled helical peptides to perturb the Cdt1–Mcm6 interaction

Journal of Peptide Science, 2015
Six all‐hydrocarbon‐stapled Cdt1 MBD‐derived peptides have been designed and synthesized to perturb the Cdt1–Mcm6 interaction, which is involved in DNA replication. Inconsistency between the helicity of the obtained peptidomimetics and their binding affinity has been observed.
Li, XC, Lee, JP, Liu, C, LI, T, Zhu, G
openaire   +4 more sources

Essential role of human CDT1 in DNA replication and chromatin licensing

Journal of Cell Science, 2002
Formation of pre-replicative complexes at origins is an early cell cycle event essential for DNA duplication. A large body of evidence supports the notion that Cdc6 protein, through its interaction with the origin recognition complex, is required for pre-replicative complex assembly by loading minichromosome maintenance proteins onto DNA.
Mickael, Rialland, Francesco, Sola, Corrado, Santocanale   +2 more
openaire   +2 more sources

Coenzyme Q10 as a potent compound that inhibits Cdt1–geminin interaction

Biochimica et Biophysica Acta (BBA) - General Subjects, 2008
A human replication initiation protein Cdt1 is a very central player in the cell cycle regulation of DNA replication, and geminin down-regulates Cdt1 function by directly binding to it. It has been demonstrated that Cdt1 hyperfunction resulting from Cdt1-geminin imbalance, for example by geminin silencing with siRNA, induces DNA re-replication and ...
Yoshiyuki, Mizushina, Toshifumi, Takeuchi, Yoichi, Takakusagi, Yuko, Yonezawa, Takeshi, Mizuno, Ken-Ichiro, Yanagi, Naoko, Imamoto, Fumio, Sugawara, Kengo, Sakaguchi, Hiromi, Yoshida, Masatoshi, Fujita   +10 more
openaire   +2 more sources

Overexpression of CDT1 Is a Predictor of Poor Survival in Patients with Hepatocellular Carcinoma

Journal of Gastrointestinal Surgery, 2016
Genomic instability is a common feature in hepatocellular carcinoma. Deregulation of replication licensing factors has been shown to trigger DNA damage response contributing to genomic instability. Overexpression of DNA replication licensing factors chromatin licensing and DNA replication factor 1 (CDT1) and minichromosome maintenance complex component
Dimitrios, Karavias, Ioannis, Maroulis, Helen, Papadaki, Charalambos, Gogos, Stavros, Kakkos, Dionissios, Karavias, Vasiliki, Bravou   +6 more
openaire   +2 more sources