Results 141 to 150 of about 5,045 (159)

Structural basis for inhibition of the replication licensing factor Cdt1 by geminin

Nature, 2004
To maintain chromosome stability in eukaryotic cells, replication origins must be licensed by loading mini-chromosome maintenance (MCM2-7) complexes once and only once per cell cycle. This licensing control is achieved through the activities of geminin and cyclin-dependent kinases.
Lee, C, Hong, B, Choi, JM, Kim, Y, Watanabe, S, Ishimi, Y, Enomoto, T, Tada, S, Kim, YC, Cho, YJ   +9 more
openaire   +3 more sources

Loss-of-function of zebrafish cdt1 causes retarded body growth and underdeveloped gonads resembling human Meier-Gorlin syndrome

Journal of Zhejiang University: Science B, 2023
Li Jan Lo
exaly  

CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis

Molecular Cell, 2023
Joseph Yeeles, Nalin Ratnayeke, Mingyu Chung   +2 more
exaly  

Novel Phosphorylation Sites on Cdt1 Regulate Its Activity

2016
Origin licensing is a process responsible for preparing the genome for replication during the cell cycle. The overexpression of chromatin licensing and DNA replication factor 1 (Cdt1), an origin licensing protein, is toxic to cells because it induces re-replication of DNA.
openaire   +1 more source

CDT1 Gene

2020
openaire   +1 more source

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Proceedings of the National Academy of Sciences of the United States of America, 2021
Junkô Murai, Yves Pommier, Yasuhisa Murai   +2 more
exaly  

DNA replication factor Cdt1

Targeted Protein Database, 2008
openaire   +1 more source

CDT1

2008
openaire   +1 more source

Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines

FEBS Journal, 2004
Zoi Lygerou, Hideo Nishitani, Stavros Taraviras   +2 more
exaly  

SCF-FBXO31 E3 Ligase Targets DNA Replication Factor Cdt1 for Proteolysis in the G2 Phase of Cell Cycle to Prevent Re-replication

Journal of Biological Chemistry, 2014
Raman Sharma, Kum Kum Khanna, Pegah Johansson   +2 more
exaly