Results 121 to 130 of about 5,045 (159)

SKP2 inhibition activates tumor cell-intrinsic immunity by inducing DNA replication stress and genomic instability. [PDF]

Br J Cancer
Peng Y, Qi X, Ding L, Huang J, Liu Y, Zheng R, Fu Y, Yin L, Deng T, Ye Y, Chen S, Li X.   +11 more
europepmc   +1 more source

CDT1 is a Potential Therapeutic Target for the Progression of NAFLD to HCC and the Exacerbation of Cancer. [PDF]

Curr Genomics
He X, Ma J, Yan X, Yang X, Wang P, Zhang L, Li N, Shi Z.   +7 more
europepmc   +1 more source

Mouse Geminin Inhibits Not Only Cdt1-MCM6 Interactions but Also a Novel Intrinsic Cdt1 DNA Binding Activity

Mouse Geminin Inhibits Not Only Cdt1-MCM6 Interactions but Also a Novel Intrinsic Cdt1 DNA Binding Activity
openaire  

Coupling of cell proliferation to the segmentation clock ensures robust somite scaling

van Oostrom MJ, Li YI, Meijer WHM, Noordzij TEJC, Fountas C, Timmers E, Korving J, Thomas WM, Simons BD, Sonnen KF.   +9 more
europepmc   +1 more source

An Inactive Geminin Mutant That Binds Cdt1

Genes, 2015
The initiation of DNA replication is tightly regulated in order to ensure that the genome duplicates only once per cell cycle. In vertebrate cells, the unstable regulatory protein Geminin prevents a second round of DNA replication by inhibiting the essential replication factor Cdt1.
Benoit Miotto, Thomas J Mcgarry
exaly   +4 more sources

Regulation of Geminin and Cdt1 expression by E2F transcription factors [PDF]

Oncogene, 2004
Geminin and Cdt1 play an essential role in the initiation of DNA replication, by regulating the chromatin loading of the MCM complex. In this study, we showed that the transcription of human Geminin and Cdt1, as well as that of MCM7, is activated by transcription factors E2F1-4, but not by factors E2F5-7.
Kenichi Yoshida
exaly   +3 more sources

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CDT1, a licensing factor that limits rereplication

Molecular Cell, 2023
Cells must avoid licensing of neosynthesized DNA to prevent rereplication. In this issue of Molecular Cell, Ratnayeke et al. (2022)1 reveal how the licensing factor CDT1, prior to its degradation, inhibits DNA elongation by suppressing CMG helicase progression at replication forks.
Gergely, Rona, Michele, Pagano
openaire   +2 more sources

Geminin–Cdt1 balance is critical for genetic stability

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
A cell limits its DNA replication activity to once per cell division cycle to maintain its genomic integrity. Studies in a variety of organisms are elucidating how these controls are exercised. Key amongst these is the regulation of replication initiator proteins such as Cdt1.
Anindya Dutta
exaly   +3 more sources

Oncogenic potential of the DNA replication licensing protein CDT1 [PDF]

Oncogene, 2002
The expression of a gene, designated as Retroviral insertion site (Ris)2, was activated by retroviral DNA integration in an immortalized primitive erythroid cell line, EB-PE. Ris2 was also expressed at high levels in all human tumor cell lines analysed.
Daved Fremont, Fremont Daved H, Choi Kyunghee   +2 more
exaly   +3 more sources

CDT1 drives replication overlicensing and enhances tumorigenesis in the gut^†

The Journal of Pathology, 2023
AbstractColorectal carcinoma (CRC) is one of the most common forms of malignancy in the Western world. Recent decades have witnessed enormous progress in our understanding of the mechanisms that sustain CRC, even though the factors implicated in the initiation and progression of this neoplasia are not fully understood.
Giovanni Monteleone, Carmine Stolfi
openaire   +4 more sources