Results 111 to 120 of about 5,745 (188)

A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing

, 2013
International audienceCdt1 is required for loading the replicative DNA helicase MCM2/7, a process known as DNA replication licensing. Here we show that 129 mouse strains express a Cdt1 mutated allele with enhanced licensing activity.
Tsanov, N., David, Grégoire, Grégoire, Damien, Coulombe, P., Coulombe, Philippe, Tsanov, Nikolay, Mechali, M., Méchali, Marcel   +7 more
core   +1 more source

Genotype-phenotype associations in microtia: a systematic review

Orphanet Journal of Rare Diseases
Background Microtia is a congenital ear malformation that can occur as isolated microtia or as part of a syndrome. The etiology is currently poorly understood, although there is strong evidence that genetics has a role in the occurrence of microtia. This
Siti Isya Wahdini, Fina Idamatussilmi, Rachmaniar Pramanasari, Almas Nur Prawoto, Citrawati Dyah Kencono Wungu, Indri Lakhsmi Putri, Gunadi   +6 more
doaj   +1 more source

DNA Replication Factor Cdt1 [PDF]

, 2020
openaire   +1 more source

Regulation of Cdc18 and Cdt1 restricts S phase to once per cell cycle in fission yeast [PDF]

, 2001
In all eukaryotes, it is essential that cells maintain a strict control over S phase to ensure that DNA replication occurs once, and only once, per cell division cycle.
Yanow, Stephanie Kim
core  

DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent

, 2006
Cdt1 is an essential protein required for licensing of replication origins. Here, we show that in Schizosaccharomyces pombe, Cdt1 is proteolysed in M and G1 phases in response to DNA damage and that this mechanism seems to be conserved from yeast to ...
Erik Boye, Emma Ralph, Stephen E Kearsey
core  

Functional domains of the Xenopus replication licensing factor Cdt1. Nucleic Acids Res

, 2005
During late mitosis and early G1, replication origins are licensed for subsequent replication by loading heterohexamers of the mini-chromosome mainten-ance proteins (Mcm2-7).
Andrew Ferenbach, Anatoliy Li, J. Julian Blow, Marta Brito-martins   +3 more
core  

SauCas9-based cell cycle-dependent genome editing via AAV delivery. [PDF]

Mol Ther Adv
Matsugi E, Kishi K, Kishi A, Nagase K, Nigorikawa K, Nomura W.   +5 more
europepmc   +1 more source

Essential functions of Cdt1 and Orc6 during origin licensing

Origin licensing ensures that eukaryotic cells replicate their DNA precisely once per cell cycle. The ORC complex, together with the licensing factors Cdc6 and Cdt1, load the core of the replicative helicase (M2-7), as a double hexamer (DH).
Guerrero-Puigdevall, Marina
core   +1 more source

Replication origin flexibility: a tool to mitigate the hazards of excess replication. [PDF]

Trends Genet
Fu H, Redon CE, Brenner HM, Ack MR, Aladjem MI.   +4 more
europepmc   +1 more source

Molecular impacts of Meier-Gorlin syndrome mutations on human origin licensing. [PDF]

J Biol Chem
Yang R, Hunker O, Kim J, Bleichert F.
europepmc   +1 more source