Results 91 to 100 of about 6,157 (185)

Μελέτη της επίδρασης αντικαρκινικών χημειοθεραπευτικών φαρμάκων στη ρύθμιση του Cdt1

, 2009
Η μεταβίβαση του γενετικού υλικού στα θυγατρικά κύτταρα απαιτεί αξιοπιστία στην αντιγραφή του DNA, ακρίβεια στην κατανομή των χρωμοσωμάτων και αποτελεσματικούς μηχανισμούς επιδιόρθωσης, ώστε να ελαχιστοποιούνται οι κληρονομήσιμες μεταλλαγές στο γενετικό ...
Σταθοπούλου, Αθανασία
core  

Multi‐Scale Mapping of Gene Expression from Whole‐slide Images for Identifying Phenotype‐Associated Subpopulations

Advanced Science, Volume 13, Issue 26, 8 May 2026.
BiSCALE: A pathology‐driven deep learning framework for multi‐scale gene expression prediction from whole‐slide images. It accurately infers bulk and near‐cellular spot‐level expression, links predictions to clinical phenotypes, identifies disease‐associated niches, and enables applications in risk stratification and cell‐identity annotation, providing
Hailong Zheng, Jiajing Xie, Luqi Wang, Hailong Xie, Tong Zhi, Yujia Guo, Bofeng Zhu, Dong Wang, Yu Chen   +8 more
wiley   +1 more source

The cell cycle and DNA damage-dependent regulation of Cdt1 in schizosaccharomyces pombe [PDF]

, 2012
Cdt1 is a conserved and essential eukaryotic protein that is required for the licensing step of DNA replication. In order to control replication licensing and ensure a single round of DNA replication occurs per cell cycle, Cdt1 is subject to strict ...
Kearsey, Stephen E., Kearsey, Stephen E, Shepherd, Marianne E. A., Shepherd, Marianne E A   +3 more
core   +2 more sources

Zone Matcher: A climate‐based web application for deployment and assisted migration of forest trees

Ecosphere, Volume 17, Issue 4, April 2026.
Abstract Populations of forest trees are generally adapted to the climates they inhabit. The farther trees are moved from their local climates, the more long‐term growth and survival tend to decrease. Current tree deployment and assisted migration rely on “climate distance thresholds” (CDTs), which are climatic distances beyond which tree performance ...
Tal J. Shalev, Meridith L. McClure, Nikolas Stevenson‐Molnar, Gregory A. O'Neill, Tongli Wang, Joseph A. E. Stewart, Glenn T. Howe   +6 more
wiley   +1 more source

Regulation of the DNA licensing protein Cdt1 in Xenopus laevis embryos [PDF]

, 2014
PhD ThesisDuring each cell cycle the DNA must be replicated accurately in order to maintain genomic integrity. To ensure faithful replication of the entire genome, DNA replication must be tightly controlled.
Woodhouse, Laura
core   +1 more source

Investigation of the interplay between SKP2, CDT1 and Geminin in cancer cells

, 2015
Geminin has a dual role in the regulation of DNA replication: it inhibits replication factor CDT1 activity during the G2 phase of the cell cycle and promotes its accumulation at the G2/M transition.
Raffaella Zamponi, Andrea Ballabeni
core   +1 more source

MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis

Nature Communications
The eukaryotic helicase MCM2-7, is loaded by ORC, Cdc6 and Cdt1 as a double-hexamer onto replication origins. The insertion of DNA into the helicase leads to partial MCM2-7 ring closure, while ATP hydrolysis is essential for consecutive steps in pre ...
Sarah V. Faull, Marta Barbon, Audrey Mossler, Zuanning Yuan, Lin Bai, L. Maximilian Reuter, Alberto Riera, Christian Winkler, Indiana Magdalou, Matthew Peach, Huilin Li, Christian Speck   +11 more
doaj   +1 more source

Chromatin’s Influence on Pre-Replication Complex Assembly and Function

Biology
In all eukaryotes, the initiation of DNA replication requires a stepwise assembly of factors onto the origins of DNA replication. This is pioneered by the Origin Recognition Complex, which recruits Cdc6.
Hina Ahmad, Neha Chetlangia, Supriya G. Prasanth   +2 more
doaj   +1 more source

Cdt1 remained in active replication sites in tsTM3 cells incubated at 39°C.

, 2014
Cells were grown on glass coverslips at 34°C or 39°C for 12 hours, incubated with 10 µM EdU for 20 minutes, washed, and fixed with 4% PFA. (A) Cdt1 was indirectly immunolabeled with Alexa 594.
Kimihiko Sugaya (560676), Sonoe Inoue (560678), Yoshie Ishihara (560677), Hideo Tsuji (24799)   +3 more
core   +1 more source

Neocryptomerin targets NAE1 to induce DNA re-replication and DNA damage by inhibiting neddylation-mediated CDT1 degradation in gastric cancer

Pharmacological Research
Gastric cancer (GC) remains a globally prevalent malignancy, necessitating the development of effective therapeutics. Natural products are an important source for the development of anti-tumor drugs.
Peng Tan, Dongjun Fu, Fei Wang, Zhuguo Wang, Huiming Huang, Xuejiao Wei, Xinyu Qiu, Yufeng Gao, Ruoxin Zhang, Xiaoxue Wang, Wanying Xie, Zhongdong Hu   +11 more
doaj   +1 more source