Results 91 to 100 of about 5,745 (188)

Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability

, 2016
Successful cell proliferation requires efficient and precise genome duplication followed by accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is ...
Cook, Jeanette, Jeanette Cook, Pozo, Pedro, Pedro Pozo   +3 more
core   +1 more source

Phase Separation of PHLDB2 Drives EMT and Tumor Progression in Triple‐Negative Breast Cancer

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Liquid–liquid phase separation (LLPS) has emerged as a critical mechanism underlying oncogenic signaling and transcriptional regulation; however, its involvement in triple‐negative breast cancer (TNBC) remains largely unknown.
Min Zhang, Chanjin Liang, Ting Chen, Xingyuan Shi, Jiqing Hao   +4 more
wiley   +1 more source

A Reporter Platform to Study Therapy‐Induced Senescence in Live Cancer Cells

Small Methods, Volume 9, Issue 12, December 1, 2025.
This study describes the development and applications of a transgenic lamin‐based senescence reporter platform based on changes in lamin‐B1‐ and lamin‐A intensities during senescence‐induction. The reporter platform is a versatile tool, allowing to screen for and sort senescent cancer cells, allowing marker integration (for example incorporating IL6 ...
Jacinta van de Grint, Mengqi Huang, Ruben Sangers, Hanny Odijk, Thom Reuvers, Jose M. Heredia‐Genestar, Anja Raams, Tsung Wai Kan, Joris Pothof, Roland Kanaar, Maayke M.P. Kuijten   +10 more
wiley   +1 more source

Investigation of the interplay between SKP2, CDT1 and Geminin in cancer cells

, 2015
Geminin has a dual role in the regulation of DNA replication: it inhibits replication factor CDT1 activity during the G2 phase of the cell cycle and promotes its accumulation at the G2/M transition.
Raffaella Zamponi, Andrea Ballabeni
core   +1 more source

The cell cycle and DNA damage-dependent regulation of Cdt1 in schizosaccharomyces pombe

, 2012
Cdt1 is a conserved and essential eukaryotic protein that is required for the licensing step of DNA replication. In order to control replication licensing and ensure a single round of DNA replication occurs per cell cycle, Cdt1 is subject to strict ...
Kearsey, Stephen E., Kearsey, Stephen E, Shepherd, Marianne E. A., Shepherd, Marianne E A   +3 more
core   +2 more sources

Chromatin’s Influence on Pre-Replication Complex Assembly and Function

Biology
In all eukaryotes, the initiation of DNA replication requires a stepwise assembly of factors onto the origins of DNA replication. This is pioneered by the Origin Recognition Complex, which recruits Cdc6.
Hina Ahmad, Neha Chetlangia, Supriya G. Prasanth   +2 more
doaj   +1 more source

Neocryptomerin targets NAE1 to induce DNA re-replication and DNA damage by inhibiting neddylation-mediated CDT1 degradation in gastric cancer

Pharmacological Research
Gastric cancer (GC) remains a globally prevalent malignancy, necessitating the development of effective therapeutics. Natural products are an important source for the development of anti-tumor drugs.
Peng Tan, Dongjun Fu, Fei Wang, Zhuguo Wang, Huiming Huang, Xuejiao Wei, Xinyu Qiu, Yufeng Gao, Ruoxin Zhang, Xiaoxue Wang, Wanying Xie, Zhongdong Hu   +11 more
doaj   +1 more source

SIX3 and SIX6 interact with GEMININ via C-terminal regions

Biochemistry and Biophysics Reports, 2019
The histoarchitecture and function of eye and forebrain depend on a well-controlled balance between cell proliferation and differentiation. For example, the binding of the cell cycle regulator GEMININ to CDT1, which is a part of the pre-replication ...
Diana C. Turcu, Johan R. Lillehaug, Hee-Chan Seo   +2 more
doaj   +1 more source

CDT1 (chromatin licensing and DNA replication factor 1) [PDF]

, 2010
Review on CDT1 (chromatin licensing and DNA replication factor 1), with data on DNA, on the protein encoded, and where the gene is ...
R Deka, Deka, R, R Tamuli, Tamuli, R
core   +1 more source

SpCas9-HF1 enhances accuracy of cell cycle-dependent genome editing by increasing HDR efficiency, and by reducing off-target effects and indel rates

Molecular Therapy: Nucleic Acids
In genome editing, it is important to avoid off-target mutations so as to reduce unexpected side effects, especially for therapeutic applications. Recently, several high-fidelity versions of SpCas9 have been developed to reduce off-target mutations.
Daisuke Matsumoto, Erina Matsugi, Kanae Kishi, Yuto Inoue, Kiyomi Nigorikawa, Wataru Nomura   +5 more
doaj   +1 more source