Results 71 to 80 of about 5,045 (159)

Zone Matcher: A climate‐based web application for deployment and assisted migration of forest trees

Ecosphere, Volume 17, Issue 4, April 2026.
Abstract Populations of forest trees are generally adapted to the climates they inhabit. The farther trees are moved from their local climates, the more long‐term growth and survival tend to decrease. Current tree deployment and assisted migration rely on “climate distance thresholds” (CDTs), which are climatic distances beyond which tree performance ...
Tal J. Shalev, Meridith L. McClure, Nikolas Stevenson‐Molnar, Gregory A. O'Neill, Tongli Wang, Joseph A. E. Stewart, Glenn T. Howe   +6 more
wiley   +1 more source

Fiber Reinforcement of Soft Spider Silk Hydrogels

Macromolecular Rapid Communications, Volume 47, Issue 7, 3 April 2026.
Along the development of matrices for biomedical applications, precise tuning of the biomaterial to interact with specific cell types/tissues is essential. The fabrication of fiber mesh‐reinforced soft hydrogels made of recombinant spider silk proteins allows for the adjustment of mechanical properties and hydrogel porosity, leading to improved cell ...
Christina Heinritz, Thomas Scheibel
wiley   +1 more source

Specificity and Function of Archaeal DNA Replication Initiator Proteins

Cell Reports, 2013
Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and ...
Rachel Y. Samson, Yanqun Xu, Catarina Gadelha, Todd A. Stone, Jamal N. Faqiri, Dongfang Li, Nan Qin, Fei Pu, Yun Xiang Liang, Qunxin She, Stephen D. Bell   +10 more
doaj   +1 more source

Morphofunctional Heterogeneity and Plasticity of Glioblastoma Cells Induced to Senescence by Temozolomide

Aging Cell, Volume 25, Issue 4, April 2026.
Glioblastoma cells induced to senescence by Temozolomide are heterogeneous, with the emergence of two main states, named E‐state and F‐state, which differ in cellular morphometry, survival mechanisms, and sensitivity to autophagy modulators and senolytics. These states are dynamic, with the occurrence of morphofunctional transitions.
Solon Andrades da Rosa, Henrique Quaiato de Oliveira, Laura Boose de Mendonça, Nicole Borgmann de Oliveira, Mariane da Cunha Jaeger, Luiza Cherobini Pereira, Fernanda Dittrich Pinto Oliveira, Debora Santos‐Sousa, Fernanda Saez‐Calazans, Luana Lenz, Melike Lakadamyali, Guido Lenz, Eduardo Cremonese Filippi‐Chiela   +12 more
wiley   +1 more source

Structural insights into the Cdt1-mediated MCM2–7 chromatin loading [PDF]

Nucleic Acids Research, 2011
Initiation of DNA replication in eukaryotes is exquisitely regulated to ensure that DNA replication occurs exactly once in each cell division. A conserved and essential step for the initiation of eukaryotic DNA replication is the loading of the mini-chromosome maintenance 2-7 (MCM2-7) helicase onto chromatin at replication origins by Cdt1. To elucidate
Liu, Changdong LIFS, Wu, Rentian, Zhou, Bo, Wang, Jiafeng, Wei, Zhun, Tye, Bik Kwoon, Liang, Chun, Zhu, Guang   +7 more
openaire   +3 more sources

Integrating single-cell analysis and machine learning algorithms to explore lactylation-related molecular mechanisms and therapeutic responses in clear cell renal cell carcinoma and identifying CDT1 as a potential biomarker

Frontiers in Endocrinology
Background and aimLactylation is a novel histone modification driven by lactate accumulation, which has been implicated in clear cell renal cell carcinoma (ccRCC) progression.
Yue Zhang, Hang Zhou, Hang Zhou, Bihui Zhang, Xianchao Sun, Wangli Mei, Wangli Mei, Lin Zhou   +7 more
doaj   +1 more source

The Metacarpophalangeal Pattern Profile: An Old Method With New Insights Into the Evaluation of Short Stature

American Journal of Human Biology, Volume 38, Issue 2, February 2026.
ABSTRACT Objective To characterize the metacarpophalangeal pattern profile (MCPP) of healthy children and adolescents from São Paulo, Brazil, and to establish percentile curves by chronological age (CA), bone age (BA), and sex using the LMS method. Additionally, to compare these findings with previous population‐based data and to apply the derived ...
Marcelo Damaso Maruichi, Bruno Telma Destailleur, Giulia Maesta Apelbaum, Carlos Alberto Longui, Cristiane Kochi   +4 more
wiley   +1 more source

Chromatin’s Influence on Pre-Replication Complex Assembly and Function

Biology
In all eukaryotes, the initiation of DNA replication requires a stepwise assembly of factors onto the origins of DNA replication. This is pioneered by the Origin Recognition Complex, which recruits Cdc6.
Hina Ahmad, Neha Chetlangia, Supriya G. Prasanth   +2 more
doaj   +1 more source

Neocryptomerin targets NAE1 to induce DNA re-replication and DNA damage by inhibiting neddylation-mediated CDT1 degradation in gastric cancer

Pharmacological Research
Gastric cancer (GC) remains a globally prevalent malignancy, necessitating the development of effective therapeutics. Natural products are an important source for the development of anti-tumor drugs.
Peng Tan, Dongjun Fu, Fei Wang, Zhuguo Wang, Huiming Huang, Xuejiao Wei, Xinyu Qiu, Yufeng Gao, Ruoxin Zhang, Xiaoxue Wang, Wanying Xie, Zhongdong Hu   +11 more
doaj   +1 more source

SIX3 and SIX6 interact with GEMININ via C-terminal regions

Biochemistry and Biophysics Reports, 2019
The histoarchitecture and function of eye and forebrain depend on a well-controlled balance between cell proliferation and differentiation. For example, the binding of the cell cycle regulator GEMININ to CDT1, which is a part of the pre-replication ...
Diana C. Turcu, Johan R. Lillehaug, Hee-Chan Seo   +2 more
doaj   +1 more source