Results 81 to 90 of about 5,745 (188)

Cdt1 Variants Offer Novel Insights Into Cdt1‐MCM Interactions and an Unexpected Mechanism for Cyclin A to Block DNA Re‐Replication

The FASEB Journal, 2018
The correct execution of DNA replication is critical for normal cell proliferation. The earliest step in DNA replication is known as origin licensing. Origins are licensed by the loading of MCM complexes, an event that is restricted to G1 phase.
Pedro Nicolas Pozo, Yasemin Cole, Jacob Matson, Yizhuo Zhuo, Brenda Temple, Jeanette Gowen Cook   +5 more
openaire   +1 more source

Specificity and Function of Archaeal DNA Replication Initiator Proteins

Cell Reports, 2013
Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and ...
Rachel Y. Samson, Yanqun Xu, Catarina Gadelha, Todd A. Stone, Jamal N. Faqiri, Dongfang Li, Nan Qin, Fei Pu, Yun Xiang Liang, Qunxin She, Stephen D. Bell   +10 more
doaj   +1 more source

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

Advanced Science, Volume 13, Issue 6, 30 January 2026.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita   +18 more
wiley   +1 more source

Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.

, 2011
Cdt1 plays a critical role in DNA replication regulation by controlling licensing. In Metazoa, Cdt1 is regulated by CRL4(Cdt2)-mediated ubiquitylation, which is triggered by DNA binding of proliferating cell nuclear antigen (PCNA).
Rachel S. Deegan, Shepherd, ME, Salguero, I, Kearsey, Stephen, Deegan, RS, Guarino Almeida, Estrella, Shepherd, Marianne E. A., Guarino, E, Hui Hua, Kearsey, Stephen E., Kearsey, SE, Salguero, Israel, Deegan, Rachel S., Hua, H, Estrella Guarino, Hua, Hui, Marianne E. A. Shepherd, Israel Salguero, Stephen E. Kearsey   +18 more
core   +1 more source

The role of CDT1 and Geminin superfamiliy in genomic instability and cell fate choice

, 2020
Genome stability is mainly preserved through normal progression of the cell cycle and regulation of DNA replication in time and space. From late mitosis and during G1, pre- replicative complexes are formed in chromatin, establishing the origins of ...
Πετρόπουλος, Μιχαήλ, Petropoulos, Michail   +1 more
core   +1 more source

Multiwalled Carbon Nanotubes as Physical Drivers of Chromosome Instability and Inflammatory Responses

Small Structures, Volume 7, Issue 1, January 2026.
This article highlights the fibrous morphology of multiwalled carbon nanotubes as a key factor in their genotoxicity. Fibers physically interfere in cell division, generating binucleated cells and micronuclei, both of which are precursors of carcinogenesis.
Núria Pulido‐Artola, Joan Repullés, Marina Rodriguez‐Muñoz, Teresa Anglada, Anna Genescà   +4 more
wiley   +1 more source

Cdt1 variants reveal unanticipated aspects of interactions with cyclin/CDK and MCM important for normal genome replication

, 2018
The earliest step in DNA replication is origin licensing, which is the DNA loading of minichromosome maintenance (MCM) helicase complexes. The Cdc10-dependent transcript 1 (Cdt1) protein is essential for MCM loading during the G1 phase of the cell cycle,
Temple, Brenda, Pozo, Pedro N., Cook, Jeanette Gowen, Grant, Gavin D., Matson, Jacob P., Kedziora, Katarzyna M., Cole, Yasemin   +6 more
core   +2 more sources

Research on Full‐Duplex Data Transfer Simultaneously Based on Wireless Power System

IET Power Electronics, Volume 19, Issue 1, January/December 2026.
The power transfer of the proposed system uses a bilateral LCC‐type high‐order compensation network. The data injecting circuit (TX1 and TX2) is connected in series to the power circuit through the data coupling transformers Tdt1 and Tdt2, and the data extracting circuit (TR1 and TR2) is connected in parallel to power coils.
Baojian Ji, Dengli Qi, Yu Yan, Yufei Zhou, Feng Hong   +4 more
wiley   +1 more source

Cdt1 remained in active replication sites in tsTM3 cells incubated at 39°C.

, 2014
Cells were grown on glass coverslips at 34°C or 39°C for 12 hours, incubated with 10 µM EdU for 20 minutes, washed, and fixed with 4% PFA. (A) Cdt1 was indirectly immunolabeled with Alexa 594.
Kimihiko Sugaya (560676), Sonoe Inoue (560678), Yoshie Ishihara (560677), Hideo Tsuji (24799)   +3 more
core   +1 more source

Navigating the Core Challenges of Atropine Therapy in Myopia: A Mechanistic and Clinical Analysis of Dose, Response, and Durability

Journal of Ophthalmology, Volume 2026, Issue 1, 2026.
Myopia has emerged as a major global public health concern. Atropine, recognized as one of the foremost interventions for myopia control, has been validated for its efficacy and safety through a multitude of clinical studies. This article examines the most recent advancements in understanding atropine’s mechanisms of action, optimizing dosage ...
Qinling Jiang, Jing Yang, Xingwei Cao, Lin Mou, Yasar Sakarya   +4 more
wiley   +1 more source