Results 81 to 90 of about 5,045 (159)

Inhibitory action of polyunsaturated fatty acids on Cdt1-geminin interaction

International Journal of Molecular Medicine, 2008
A human replication initiation protein, Cdt1, is a central player in the cell cycle regulation of DNA replication, and geminin down-regulates Cdt1 function by direct binding. It has been demonstrated that Cdt1 hyperfunction resulting from Cdt1-geminin imbalance, for example, by geminin silencing with small interfering RNA, induces DNA re-replication ...
Yoshiyuki, Mizushina, Toshifumi, Takeuchi, Yoichi, Takakusagi, Fumio, Sugawara, Kengo, Sakaguchi, Hiromi, Yoshida, Masatoshi, Fujita   +6 more
openaire   +3 more sources

DCAF14 regulates CDT2 to promote SET8-dependent replication fork protection

Life Science Alliance
DCAF14 modulates CRL4 CDT2 -dependent turnover during DNA replication. Loss of DCAF14 causes nascent strand degradation due to excessive proteasomal turnover of SET8 by aberrant CDT2 activity. DDB1- and CUL4-associated factors (DCAFs) CDT2 and DCAF14 are
Neysha Tirado-Class, Caitlin Hathaway, Anthony Nelligan, Thuan Nguyen, Huzefa Dungrawala   +4 more
doaj   +1 more source

SpCas9-HF1 enhances accuracy of cell cycle-dependent genome editing by increasing HDR efficiency, and by reducing off-target effects and indel rates

Molecular Therapy: Nucleic Acids
In genome editing, it is important to avoid off-target mutations so as to reduce unexpected side effects, especially for therapeutic applications. Recently, several high-fidelity versions of SpCas9 have been developed to reduce off-target mutations.
Daisuke Matsumoto, Erina Matsugi, Kanae Kishi, Yuto Inoue, Kiyomi Nigorikawa, Wataru Nomura   +5 more
doaj   +1 more source

CDT1 wt Allele [PDF]

, 2020
openaire   +1 more source

DNA Replication Factor Cdt1 [PDF]

, 2020
openaire   +1 more source

Genotype-phenotype associations in microtia: a systematic review

Orphanet Journal of Rare Diseases
Background Microtia is a congenital ear malformation that can occur as isolated microtia or as part of a syndrome. The etiology is currently poorly understood, although there is strong evidence that genetics has a role in the occurrence of microtia. This
Siti Isya Wahdini, Fina Idamatussilmi, Rachmaniar Pramanasari, Almas Nur Prawoto, Citrawati Dyah Kencono Wungu, Indri Lakhsmi Putri, Gunadi   +6 more
doaj   +1 more source

SauCas9-based cell cycle-dependent genome editing via AAV delivery. [PDF]

Mol Ther Adv
Matsugi E, Kishi K, Kishi A, Nagase K, Nigorikawa K, Nomura W.   +5 more
europepmc   +1 more source

Replication origin flexibility: a tool to mitigate the hazards of excess replication. [PDF]

Trends Genet
Fu H, Redon CE, Brenner HM, Ack MR, Aladjem MI.   +4 more
europepmc   +1 more source

Molecular impacts of Meier-Gorlin syndrome mutations on human origin licensing. [PDF]

J Biol Chem
Yang R, Hunker O, Kim J, Bleichert F.
europepmc   +1 more source

License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication. [PDF]

Bioessays
Frisbie V, Bleichert F.
europepmc   +1 more source