Results 81 to 90 of about 6,157 (185)

Natural leaf shape variation reveals diverse transcriptional targets of GmJAG1 during soybean leaf development

The Plant Journal, Volume 127, Issue 4, August 2026.
SUMMARY The JAGGED transcription factor family regulates lateral organ development across angiosperms. In soybean (Glycine max Merr.), a D9H mutation in the EAR repression motif of GmJAG1 causes a narrow‐leaflet phenotype and explains over 70% of phenotypic variance in leaf shape. Because this mutation does not affect the zinc finger DNA‐binding domain,
Bishal G. Tamang, Casey Kramer, Elizabeth A. Ainsworth   +2 more
wiley   +1 more source

Analysis of a temperature‐sensitive mutation in Uba1: Effects of the click reaction on subsequent immunolabeling of proteins involved in DNA replication

FEBS Open Bio, 2015
In our previous study, a Met‐to‐Ile substitution at amino acid 256 in the catalytic domain of Uba1 was determined in temperature‐sensitive CHO‐K1 mutant tsTM3 cells, which exhibited chromosomal instability and cell‐cycle arrest in the S to G2 phases with
Kimihiko Sugaya, Yoshie Ishihara, Sonoe Inoue   +2 more
doaj   +1 more source

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Cdt1 Variants Offer Novel Insights Into Cdt1‐MCM Interactions and an Unexpected Mechanism for Cyclin A to Block DNA Re‐Replication

The FASEB Journal, 2018
The correct execution of DNA replication is critical for normal cell proliferation. The earliest step in DNA replication is known as origin licensing. Origins are licensed by the loading of MCM complexes, an event that is restricted to G1 phase.
Pedro Nicolas Pozo, Yasemin Cole, Jacob Matson, Yizhuo Zhuo, Brenda Temple, Jeanette Gowen Cook   +5 more
openaire   +1 more source

Repression of Nascent Strand Elongation by Deregulated Cdt1 during DNA Replication in Xenopus Egg Extracts

, 2009
Excess Cdt1 reportedly induces rereplication of chromatin in cultured cells and Xenopus egg extracts, suggesting that the regulation of Cdt1 activity by cell cycle-dependent proteolysis and expression of the Cdt1 inhibitor geminin is crucial for the ...
Enomoto, T, Ayako Aoki, Masayuki Seki, Tada, S, Tsuyama, T, Saori Watanabe, Aoki, A, Takemi Enomoto, Takashi Tsuyama, Yunje Cho, Shusuke Tada, Watanabe, S, Cho, Y, Seki, M   +13 more
core   +1 more source

Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability [PDF]

, 2016
Successful cell proliferation requires efficient and precise genome duplication followed by accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is ...
Cook, Jeanette, Jeanette Cook, Pozo, Pedro, Pedro Pozo   +3 more
core   +1 more source

Specificity and Function of Archaeal DNA Replication Initiator Proteins

Cell Reports, 2013
Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and ...
Rachel Y. Samson, Yanqun Xu, Catarina Gadelha, Todd A. Stone, Jamal N. Faqiri, Dongfang Li, Nan Qin, Fei Pu, Yun Xiang Liang, Qunxin She, Stephen D. Bell   +10 more
doaj   +1 more source

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

Advanced Science, Volume 13, Issue 31, 4 June 2026.
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan, Keshav Gajendra Babu, Markus Mukenhirn, Antje Garside, Vinita Ajit Kini, Trishla Adhikari, Timon Beck, Byung Ho Lee, Kyoohyun Kim, Carsten Werner, Raimund Schlüßler, Alf Honigmann, Sebastian Aland, Anna Verena Taubenberger   +13 more
wiley   +1 more source

The role of CDT1 and Geminin superfamiliy in genomic instability and cell fate choice

, 2020
Genome stability is mainly preserved through normal progression of the cell cycle and regulation of DNA replication in time and space. From late mitosis and during G1, pre- replicative complexes are formed in chromatin, establishing the origins of ...
Πετρόπουλος, Μιχαήλ, Petropoulos, Michail   +1 more
core   +1 more source

Pitfalls and missing links in current understanding of 4D genomes

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The spatial and temporal organization of the genome—collectively termed the 4D genome—is pivotal for regulating gene expression, maintaining genome stability, and guiding development. The convergence of chromosome conformation capture technologies, super‐resolution microscopy, and single‐cell epigenomics has transformed our understanding of ...
Michael Q. Zhang
wiley   +1 more source