Results 101 to 110 of about 5,745 (188)

Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.

PLoS ONE, 2012
Disruption of early mitotic inhibitor 1 (Emi1) interferes with normal cell cycle progression and results in early embryonic lethality in vertebrates. During S and G2 phases the ubiquitin ligase complex APC/C is inhibited by Emi1 protein, thereby enabling
Mara E Robu, Yong Zhang, Jennifer Rhodes
doaj   +1 more source

Inhibitory action of polyunsaturated fatty acids on Cdt1-geminin interaction

International Journal of Molecular Medicine, 2008
A human replication initiation protein, Cdt1, is a central player in the cell cycle regulation of DNA replication, and geminin down-regulates Cdt1 function by direct binding. It has been demonstrated that Cdt1 hyperfunction resulting from Cdt1-geminin imbalance, for example, by geminin silencing with small interfering RNA, induces DNA re-replication ...
Yoshiyuki, Mizushina, Toshifumi, Takeuchi, Yoichi, Takakusagi, Fumio, Sugawara, Kengo, Sakaguchi, Hiromi, Yoshida, Masatoshi, Fujita   +6 more
openaire   +3 more sources

DCAF14 regulates CDT2 to promote SET8-dependent replication fork protection

Life Science Alliance
DCAF14 modulates CRL4 CDT2 -dependent turnover during DNA replication. Loss of DCAF14 causes nascent strand degradation due to excessive proteasomal turnover of SET8 by aberrant CDT2 activity. DDB1- and CUL4-associated factors (DCAFs) CDT2 and DCAF14 are
Neysha Tirado-Class, Caitlin Hathaway, Anthony Nelligan, Thuan Nguyen, Huzefa Dungrawala   +4 more
doaj   +1 more source

Regulation of the DNA licensing protein Cdt1 in Xenopus laevis embryos [PDF]

, 2014
PhD ThesisDuring each cell cycle the DNA must be replicated accurately in order to maintain genomic integrity. To ensure faithful replication of the entire genome, DNA replication must be tightly controlled.
Woodhouse, Laura
core  

Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase

, 2017
Cdt1 is rapidly degraded by CRL4Cdt2 E3 ubiquitin ligase after UV (UV) irradiation. Previous reports revealed that the nucleotide excision repair (NER) pathway is responsible for the rapid Cdt1-proteolysis.
Kaoru Sugasawa (2722474), Wataru Sakai (213721), Michiyo Takahara (709220), Kohei Nukina (709219), Yasushi Shiomi (304958), Akiyo Hayashi (3825547), Hideo Nishitani (304959), Miyuki Tanaka (2589223)   +7 more
core   +1 more source

Recombinant Cdt1 Induces Rereplication of G2 Nuclei in Xenopus Egg Extracts

, 2005
A crucial regulation for maintaining genome integrity in eukaryotes is to limit DNA replication in S phase to only one round. Several models have been proposed; one of which, the licensing model, predicted that formation of the nuclear membrane restricts
Mechali, Marcel, Maiorano, Domenico, Krasinska, Liliana, Lutzmann, Malik   +3 more
core   +1 more source

DETERMINING THE CELLULAR AND MOLECULAR CONSEQUENCES OF NATURALLY-OCCURRING AND ENGINEERED MUTATIONS IN THE CELL CYCLE GENE CDT1

, 2019
The cell division cycle is composed of two major events; 1. DNA replication (S phase) and 2. chromosome segregation (M phase). In addition, gap phases exist to prepare cells for the duplication of their entire genome (G1 phase) and to check that the ...
Pozo, Pedro Nicolas
core   +1 more source

Evidence for a role of Arabidopsis CDT1 proteins in gametophyte development and maintenance of genome integrity

, 2012
Meristems retain the ability to divide throughout the life cycle of plants, which can last for over 1000 years in some species. Furthermore, the germline is not laid down early during embryogenesis but originates from the meristematic cells relatively ...
Benhamed, Moussa, Van De Slijke, Eveline, Bourge, Mickaël, Blanchet, Sophie, De Veylder, Lieven, De Jaeger, Geert, Bergounioux, Catherine, Domenichini, Séverine, Raynaud, Cécile   +8 more
core   +1 more source

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

, 2009
All organisms need to ensure that no DNA segments are rereplicated in a single cell cycle. Eukaryotes achieve this through a process called origin licensing, which involves tight spatiotemporal control of the assembly of prereplicative complexes (pre-RCs)
Iliou, M. S., Medema, R. H., Karantzelis, N., Perrakis, A., Lygerou, Z., Blow, J. J., Gillespie, P. J., Svergun, D. I., Christodoulou, E., van Gerwen, S., Klompmaker, R., De Marco, V., Taraviras, S., Li, A., Fish, A., Petoukhov, M. V., Blow, J.J.; id_orcid   +16 more
core   +1 more source

CDT1 wt Allele [PDF]

, 2020
openaire   +1 more source