Results 101 to 110 of about 6,157 (185)

SIX3 and SIX6 interact with GEMININ via C-terminal regions

Biochemistry and Biophysics Reports, 2019
The histoarchitecture and function of eye and forebrain depend on a well-controlled balance between cell proliferation and differentiation. For example, the binding of the cell cycle regulator GEMININ to CDT1, which is a part of the pre-replication ...
Diana C. Turcu, Johan R. Lillehaug, Hee-Chan Seo   +2 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

DCAF14 regulates CDT2 to promote SET8-dependent replication fork protection

Life Science Alliance
DCAF14 modulates CRL4 CDT2 -dependent turnover during DNA replication. Loss of DCAF14 causes nascent strand degradation due to excessive proteasomal turnover of SET8 by aberrant CDT2 activity. DDB1- and CUL4-associated factors (DCAFs) CDT2 and DCAF14 are
Neysha Tirado-Class, Caitlin Hathaway, Anthony Nelligan, Thuan Nguyen, Huzefa Dungrawala   +4 more
doaj   +1 more source

SpCas9-HF1 enhances accuracy of cell cycle-dependent genome editing by increasing HDR efficiency, and by reducing off-target effects and indel rates

Molecular Therapy: Nucleic Acids
In genome editing, it is important to avoid off-target mutations so as to reduce unexpected side effects, especially for therapeutic applications. Recently, several high-fidelity versions of SpCas9 have been developed to reduce off-target mutations.
Daisuke Matsumoto, Erina Matsugi, Kanae Kishi, Yuto Inoue, Kiyomi Nigorikawa, Wataru Nomura   +5 more
doaj   +1 more source

CDT1 wt Allele [PDF]

, 2020
openaire   +1 more source

DNA Replication Factor Cdt1 [PDF]

, 2020
openaire   +1 more source

Genotype-phenotype associations in microtia: a systematic review

Orphanet Journal of Rare Diseases
Background Microtia is a congenital ear malformation that can occur as isolated microtia or as part of a syndrome. The etiology is currently poorly understood, although there is strong evidence that genetics has a role in the occurrence of microtia. This
Siti Isya Wahdini, Fina Idamatussilmi, Rachmaniar Pramanasari, Almas Nur Prawoto, Citrawati Dyah Kencono Wungu, Indri Lakhsmi Putri, Gunadi   +6 more
doaj   +1 more source

A novel homozygous intronic variant in CDT1 that alters splicing causes Meier–Gorlin syndrome, and a review of published mutations and growth hormone treatments

Orphanet Journal of Rare Diseases
Background Meier–Gorlin syndrome (MGORS) is a rare autosomal inherited form of primordial dwarfism. Pathogenic variants in 13 genes involved in DNA replication initiation have been identified in this disease, but homozygous intronic variants have never ...
Qing Li, Yichi Wu, Fucheng Meng, Zhuxi Li, Di Zhan, Xiaoping Luo   +5 more
doaj   +1 more source

Essential functions of Cdt1 and Orc6 during origin licensing

Origin licensing ensures that eukaryotic cells replicate their DNA precisely once per cell cycle. The ORC complex, together with the licensing factors Cdc6 and Cdt1, load the core of the replicative helicase (M2-7), as a double hexamer (DH).
Guerrero-Puigdevall, Marina
core   +2 more sources

Prognostic and immunotherapeutic implications of histamine-related biomarkers in lung adenocarcinoma. [PDF]

PeerJ
Chen F, Wang J, Yang J, Yuan Y, Luo H, Peng J, Yan C, Zhang Z.   +7 more
europepmc   +1 more source