The ubiquitin‐like domain 2 (Ubl2) of the SARS‐CoV‐2 virus is necessary for the stability and catalytic efficiency of its papain‐like protease (PLpro). Our crystallographic study reveals that the Ubl2 domain exhibits notable flexibility and can adopt a conformation that places itself away from the PLpro catalytic domain, representing a new conformation
Gian Luca Freiherr von Scholley +7 more
wiley +1 more source
Research status and progress on the relationship between obstructive sleep apnea and pulmonary nodules. [PDF]
Fu Y, Xiao L.
europepmc +1 more source
Benchmarked Colorectal Cancer Outcomes in a Metropolitan Hospital: A 5‐Year Review
In metastatic disease, patients with lung‐only metastasis had the best 5‐year survival at 46.0% and curative‐intent approaches can dramatically improve survival. ABSTRACT Introduction Colorectal cancer (CRC) remains a major contributor to cancer‐related mortality worldwide, with survival influenced by many prognostic factors.
Jialin Du +3 more
wiley +1 more source
Text mining methods for automated data extraction from health technology assessment reports of medicines using classical natural language processing and generative artificial intelligence. [PDF]
Versteeg JW +8 more
europepmc +1 more source
Targeted Systemic Therapies for Atopic Dermatitis in Australia: A Narrative Review
ABSTRACT Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease estimated to affect approximately 30% of children and 10%–15% of adults in Australia. Of those with this condition, one in five is estimated to have moderate‐to‐severe disease.
Diana Rubel +5 more
wiley +1 more source
Hemolytic and Co-Hemolytic Activity of Trichophyton indotineae and Related Dermatophytes Isolated from Chronic and Recalcitrant Infections. [PDF]
Bingöl O +4 more
europepmc +1 more source
Feasibility of MEG in assessing task-related oscillatory markers and evaluating cognitive changes in recently symptomatic carotid endarterectomy patients: A pilot study. [PDF]
Kukkonen T +6 more
europepmc +1 more source

