Results 41 to 50 of about 472,906 (286)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

The Prognostic Value of Biomarkers on Detecting Non-Small Cell Lung Cancer in a Chinese Elderly Population

open access: yesInternational Journal of General Medicine, 2021
Lianghua Guo,1 Bin Song,1 Jianhong Xiao,1 Hui Lin,1 Junhua Chen,1 Xianghua Su2 1Department of Respiratory Medicine, Mindong Hospital of Fujian Medical University, Fuan City, 355000, People’s Republic of China; 2Department of Neurosurgery, Mindong ...
Guo L   +5 more
doaj  

Association between Carotid Bifurcation Angle and Vulnerable Plaque Volume Using Black Blood Magnetic Resonance Imaging

open access: yesNeurologia Medico-Chirurgica, 2023
The morphology of the internal carotid artery (ICA) bifurcation is increasingly being recognized as the cause of atherosclerosis and vulnerable plaque leading to cerebral infarction.
Hiroki TAKAI   +8 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

RXJ1856.5-3754 and RXJ0720.4-3125 are P-Stars

open access: yes, 2004
P-stars are a new class of compact stars made of up and down quarks in $\beta$-equilibrium with electrons in a chromomagnetic condensate. P-stars are able to account for compact stars with $R \lesssim 6 Km$, as well as stars comparable to canonical ...
Cea, Paolo
core   +1 more source

Long-wavelength excitations of Higgs condensates [PDF]

open access: yes, 2001
Quite independently of the Goldstone phenomenon, recent lattice data suggest the existence of gap-less modes in the spontaneously broken phase of a $\lambda \Phi^4$ theory.
Cea   +9 more
core   +3 more sources

CEA-based vaccines

open access: yesExpert Review of Vaccines, 2002
Carcinoembryonic antigen (CEA), the first tumor-associated antigen to be described, was cloned in 1987 and is expressed on nearly 50% of all human tumors. The identification of T-cell specific epitopes within the coding region of the CEA protein has led to the development of various vaccine strategies that target CEA and CEA-expressing tumors.
Emina H, Huang, Howard L, Kaufman
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Diagnosis of medullary thyroid cancer and prognostic factors of disease aggressiveness

open access: yesЭндокринная хирургия, 2013
In the study were enrolled 137 patients with medullary thyroid cancer (MTC). Low 35%-sensitivity of FNAC and high accuracy of basal calcitonin in MTC diagnostics were found.
D O Gazizova   +4 more
doaj   +1 more source

Primary Cutaneous Mucinous Carcinoma Monitoring: A Role for CA15.3 and CEA?

open access: yesCase Reports in Oncology, 2022
Primary cutaneous mucinous carcinoma (PCMC) is a rare malignant skin adnexal tumor. Recurrences are most often localized, and long-term follow-up after complete surgery consists essentially of self-examination of skin.
Antonin Ginguay   +5 more
doaj   +1 more source

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