Results 171 to 180 of about 10,239 (195)

Cell-Penetrating CEBPB and CEBPD Leucine Zipper Decoys as Broadly Acting Anti-Cancer Agents [PDF]

Cancers, 2021
Transcription factors are key players underlying cancer formation, growth, survival, metastasis and treatment resistance, yet few drugs exist to directly target them. Here, we characterized the in vitro and in vivo anti-cancer efficacy of novel synthetic
James Angelastro, Markus Siegelin, Thi Thu Trang Nguyen   +2 more
exaly   +2 more sources

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Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB

Nature, 2011
There is an emerging consensus that gene regulation evolves through changes in cis-regulatory elements and transcription factors. Although it is clear how nucleotide substitutions in cis-regulatory elements affect gene expression, it is not clear how amino-acid substitutions in transcription factors influence gene regulation.
Vincent J, Lynch, Gemma, May, Günter P, Wagner   +2 more
openaire   +2 more sources

The transcription factors Creb1 and CEBPB regulate Sox9 promoter activity in TM4 Sertoli cells

Gene, 2023
In Sertoli cells, the Sox9 gene is essential for testicular development and normal spermatogenesis. SOX9 is critical for postnatal Sertoli cells differentiation and proliferation in the testis. However, the molecular mechanisms that specifically regulate its expression are not entirely understood.
Mariama Diawara, Aurélie Arsenault, Sabrina Ayoub Charette, Luc J. Martin   +3 more
openaire   +2 more sources

A novel PAK4-CEBPB-CLDN4 axis involving in breast cancer cell migration and invasion

Biochemical and Biophysical Research Communications, 2019
Claudin-4 (CLDN4), a crucial member of tight junction proteins, is aberrantly expressed in breast cancer cells and contributes to cell migration and invasion. However, the mechanisms controlling CLDN4 expression in breast cancer are poorly understood.
Furong Liu, Ke Ning
exaly   +3 more sources

Epigenetic regulation of Cebpb activation by pY19-Caveolin-2 at the nuclear periphery in association with the nuclear lamina

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2022
Here, we show that Caveolin-2 (Cav-2) is an epigenetic regulator for adipogenesis. Upon adipogenic stimulation, inner nuclear membrane (INM)-targeted pY19-Cav-2 interacted with lamin A/C to disengage the repressed Cebpb promoter from lamin A/C, which facilitated the Cebpb promoter association with lamin B1.
Moonjeong, Choi, Hayeong, Kwon, Kyuho, Jeong, Yunbae, Pak   +3 more
openaire   +2 more sources

CEBPB inhibition via miRNA298-5p mediates inflammation in ARDS 3885

The Journal of Immunology
Abstract Description   Acute Respiratory Distress Syndrome (ARDS) poses a significant risk in advanced COVID-19 and other inflammatory conditions. Characterized by damage to the pulmonary endothelium and epithelium, leading to pulmonary edema, hypoxemia, and excessive inflammation.
Jordan Ellette Williams, Prakash S. Nagarkatti, Mitzi Nagarkatti, Kiesha Maria Wilson   +3 more
openaire   +1 more source

Lactate drive M2 polarization via OXPHOS and Cebpb and accelerate peripheral nerve regeneration

International Immunopharmacology
Persistent inflammation impedes peripheral nerve regeneration, in which infiltrating macrophages play pivotal roles by regulating the M1/M2 phenotypic balance. M2 macrophages facilitate repair, yet factors driving M1-to-M2 transition remain unclear. Lactate, a key metabolic byproduct in injured tissue, dynamically regulates microenvironmental signaling.
Wei, Li, Xiao, Wang, Xiaoli, Liu, Luoyang, Wang, Jie, Liang, Yu, Cui, Yi, Liu, Mengting, Zhou, Zijie, Yang, Meiying, Song, Yanyan, Yang, Li, Zhang, Bei, Zhang   +12 more
openaire   +2 more sources

Oxidative Stress and Pyroptosis Mediated by CEBPB/HMGB1 Signaling in Sepsis-Exacerbated Coronary Atherosclerosis

Antioxidants & Redox Signaling
Aims: This study explores the role of oxidative stress and the CEBPB/HMGB1/VCAM1 signaling axis in sepsis-exacerbated coronary artery disease (CAD). Methods: A sepsis-exacerbated CAD model was established in male
Shuyao Zhang, Wei He, Xinyue Lin, Chengkuan Zhao, Danling Zheng, Chaoxian Lin, Chengcheng Xu, Wang Chen, Yun Chen, Qianhua Luo, Xiaolong Wu, Jianxiang Huang, Yuying Huang, Zhihan Zhang, Haiyan Mai   +14 more
openaire   +2 more sources

HDAC4 super-enhancer drives CEBPB-mediated TWIST2 transcription to promote chemoresistance in LUAD

Cancer Letters
Lung cancer remains one of the most prevalent malignancies worldwide. This study investigates the role of histone deacetylase 4 (HDAC4) in mediating chemoresistance in lung adenocarcinoma (LUAD). Super-enhancers (SEs), known to regulate aberrant gene expression, are critical drivers of tumor progression.
Min Jiang, Kai Zhang, Guohao Wei, Feng Qi, Danlei Yu, Jingjing Ma, Xiaofei Zhang, Longbang Chen, Yuhao Xie, Zhengyuan Yu, Jing Chen, Dongqin Chen   +11 more
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Metformin inhibits human non-small cell lung cancer by regulating AMPK–CEBPB–PDL1 signaling pathway

Cancer Immunology, Immunotherapy, 2021
Jiang Wei, Tao Lu
exaly