Results 1 to 10 of about 3,614 (168)

Identifying Genetic Variants in Patients With Cefaclor‐Induced Anaphylaxis Using Human Leukocyte Antigen Typing and Whole‐Exome Sequencing [PDF]

Clinical and Translational Allergy
Background Cefaclor is a commonly prescribed β‐lactam antibiotic and a known major cause of immediate‐type drug hypersensitivity in Korea. However, its genetic risk factors remain poorly understood.
Sung‐Ryeol Kim, Da Eun Lee, Hyun Young Jung, In‐Wha Kim, Hye‐Ryun Kang, Kyung Hee Park, Jung‐Won Park, Jung‐Mi Oh, Jae‐Hyun Lee   +8 more
doaj   +3 more sources

A Case of Staphylococcus aureus Septic Arthritis After COVID‐19 Vaccination [PDF]

Journal of General and Family Medicine
Septic arthritis is a serious medical emergency associated with high morbidity and mortality. A 49‐year‐old man with diabetes undergoing hemodialysis developed right shoulder pain and fever following his sixth dose of the COVID‐19 vaccine.
Mineto Ohta, Rikiya Kanba, Masataka Kudo, Kazuki Kawashima, Kenji Namiki   +4 more
doaj   +3 more sources

Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects

Pharmaceutics, 2021
The aims of this study were: (1) to perform population pharmacokinetic analysis of cefaclor in healthy Korean subjects, and (2) to investigate possible effects of various covariates on pharmacokinetic parameters of cefaclor.
Hea-Young Cho, Yong-Bok Lee
exaly   +3 more sources

In Vitro Activity of Cefaclor/Beta-Lactamases Inhibitors (Clavulanic Acid and Sulbactam) Combination Against Extended-Spectrum Beta-Lactamase Producing Uropathogenic E. coli [PDF]

Antibiotics
Background: Urinary tract infections (UTIs) caused by the multidrug resistance (MDR) phenotype termed extended-spectrum beta lactamase (ESBL)-producing E. coli is a significant and growing global health concern.
Ali Atoom, Bayan Alzubi, Dana Barakat, Rana Abu-Gheyab, Dalia Ismail-Agha, Awatef Al-Kaabneh, Nawfal Numan   +6 more
doaj   +2 more sources

Highlighting the Role of Prenatally Administered Drugs in the Production of Dental Enamel Defects in Rats by Polarized Light Microscopy [PDF]

Biomedicines
Background/Objectives: Although factors acting both prenatally and postnatally are taken into consideration, the etiopathogenesis of developmental defects of enamel (DDE) is not fully understood.
Mihai Popescu, Marilena Bătăiosu, Stelian-Mihai-Sever Petrescu, Mihaela Ionescu, Marius Ciprian Văruț, Diana Elena Vlăduțu, Tiberius-Cătălin Dudan, Adina-Monica Chiriac, Camelia Fiera (Maglaviceanu), Veronica Mercuț   +9 more
doaj   +2 more sources

Clinical characteristics and risk factors for cefaclor-induced immediate hypersensitivity: a retrospective observation at two university hospitals in Korea

Allergy, Asthma & Clinical Immunology, 2021
Background Cefaclor, a second-generation oral cephalosporin, is widely prescribed to treat infectious diseases. Immediate hypersensitivity (HS) reactions to cefaclor have continuously been reported and are expected to increase with its greater use.
Hyo-In Rhyou, Go-Eun Doo, Jiwon Yoon, Chae-Yeon Ha, Hee-Joo Nam, Sung-Dae Woo, Youngsoo Lee, Young-Hee Nam, Young-Min Ye   +8 more
doaj   +1 more source

Cefaclor-induced hypersensitivity: Differences in the incidence of anaphylaxis relative to other 2nd and 3rd generation cephalosporins.

PLoS ONE, 2021
Cefaclor, a second-generation oral cephalosporin, is the most frequently prescribed cephalosporin in Korea. Studies, however, have yet to analyze the incidence of cefaclor-associated adverse drug reactions (ADRs), including hypersensitivity (HS ...
Hyo-In Rhyou, Young-Hee Nam, Su-Chin Kim, Go-Eun Doo, Chae-Yeon Ha, Hee-Joo Nam, Sung-Dae Woo, Youngsoo Lee, Jae-Hyuk Jang, Hyun-Young Lee, Young-Min Ye   +10 more
doaj   +1 more source

Intradermal testing increases the accuracy of an immediate-type cefaclor hypersensitivity diagnosis

World Allergy Organization Journal, 2022
Background: Hypersensitivity reactions to cefaclor have increased in accordance with its frequent use. However, only limited data are available on the diagnostic value of skin tests for these conditions, particularly intradermal tests (IDTs).
Ji-Hyang Lee, MD, PhD, Chan Sun Park, MD, PhD, Min Ju Pyo, BS, A. Ryang Lee, BS, Eunyong Shin, MD, Young-Sang Yoo, MD, Woo-Jung Song, MD, PhD, Tae-Bum Kim, MD, PhD, You-Sook Cho, MD, PhD, Hyouk-Soo Kwon, MD, PhD   +9 more
doaj   +1 more source

Pharmacokinetics and safety of the two oral cefaclor formulations in healthy chinese subjects in the fasting and postprandial states

Frontiers in Pharmacology, 2022
We conducted a phase I bioequivalence trial in healthy Chinese subjects in the fasting and postprandial states. The goal of this trial was to compare the pharmacokinetics and safety of the test preparation Cefaclor granule (Disha Pharmaceutical Group Co.,
Xinyao Qu, Qiaohuan Deng, Ying Li, Peng Li, Guangwen Liu, Yanli Wang, Zhengzhi Liu, Shuang Yu, Yang Cheng, Yannan Zhou, Jiahui Chen, Qing Ren, Zishu Yu, Zhengjie Su, Yicheng Zhao, Haimiao Yang   +15 more
doaj   +1 more source

Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice

Scientific Reports, 2023
Antibiotics are increasingly recognized as causing neuropsychiatric side effects including depression and anxiety. Alterations in central serotonin and 5-HT receptor expression are implicated in the pathogenesis of anxiety and depression, which are ...
Min-Kyung Joo, Yoon-Jung Shin, Dong-Hyun Kim   +2 more
doaj   +1 more source