Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects
Pharmaceutics, 2021 The aims of this study were: (1) to perform population pharmacokinetic analysis of cefaclor in healthy Korean subjects, and (2) to investigate possible effects of various covariates on pharmacokinetic parameters of cefaclor.
Yong-Bok Lee +2 more
exaly +4 more sources
HLA-DRB1 is associated with cefaclor-induced immediate hypersensitivity [PDF]
World Allergy Organization JournalBackground: Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little is yet known about genetic biomarkers to
Tae-Bum Kim, Cheol Woo Kim
exaly +6 more sources
Clinical characteristics and risk factors for cefaclor-induced immediate hypersensitivity: a retrospective observation at two university hospitals in Korea [PDF]
Allergy, Asthma & Clinical Immunology, 2021 Background Cefaclor, a second-generation oral cephalosporin, is widely prescribed to treat infectious diseases. Immediate hypersensitivity (HS) reactions to cefaclor have continuously been reported and are expected to increase with its greater use.
Hyo-In Rhyou +8 more
doaj +2 more sources
Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice
Scientific Reports, 2023 Antibiotics are increasingly recognized as causing neuropsychiatric side effects including depression and anxiety. Alterations in central serotonin and 5-HT receptor expression are implicated in the pathogenesis of anxiety and depression, which are ...
Min-Kyung Joo +2 more
doaj +2 more sources
Performance of PEN-FAST and CEPH-FAST for Cephalosporin Allergy Delabeling. [PDF]
Clin Transl AllergyEvaluation of PEN‐FAST and CEPH‐FAST in 100 patients with cephalosporin allergy labels showed that PEN‐FAST reliably identified low‐risk patients suitable for direct drug challenge, while CEPH‐FAST demonstrated reduced diagnostic performance. ABSTRACT Background Unverified antibiotic allergy labels lead to suboptimal antimicrobial prescribing and ...
Göcebe D +4 more
europepmc +2 more sources
Cefaclor-induced hypersensitivity: Differences in the incidence of anaphylaxis relative to other 2nd and 3rd generation cephalosporins. [PDF]
PLoS ONE, 2021 Cefaclor, a second-generation oral cephalosporin, is the most frequently prescribed cephalosporin in Korea. Studies, however, have yet to analyze the incidence of cefaclor-associated adverse drug reactions (ADRs), including hypersensitivity (HS ...
Hyo-In Rhyou +10 more
doaj +2 more sources
Spectrophotometric determination of cefaclor in pharmaceutical preparations
Química Nova, 1999 A simple spectrophotometric method is proposed for the determination of cefaclor. The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm.
Viviane M. Ivama +3 more
doaj +2 more sources
Identifying Genetic Variants in Patients With Cefaclor‐Induced Anaphylaxis Using Human Leukocyte Antigen Typing and Whole‐Exome Sequencing [PDF]
Clinical and Translational AllergyBackground Cefaclor is a commonly prescribed β‐lactam antibiotic and a known major cause of immediate‐type drug hypersensitivity in Korea. However, its genetic risk factors remain poorly understood.
Sung‐Ryeol Kim +8 more
doaj +2 more sources
Preparation, molecular docking, and biological evaluation of radioiodinated cefaclor for inflammation detection [PDF]
BMC Pharmacology and ToxicologyBackground Inflammation serves as a natural defense mechanism; however, its persistence can lead to chronic diseases with serious clinical consequences.
H. Hussien +4 more
doaj +2 more sources
A Case of Silicone Allergy Induced by a Subcutaneous Implantable Cardioverter Defibrillator. [PDF]
J ArrhythmA 54‐year‐old man developed a granulomatous lesion 7 months after S‐ICD implantation and generator exposure 6 years later. Negative infection workup and positive patch testing supported silicone‐related hypersensitivity. To our knowledge, this is the first reported case of silicone allergy associated with an S‐ICD system.
Shinkai W +9 more
europepmc +2 more sources