Identifying Genetic Variants in Patients With Cefaclor‐Induced Anaphylaxis Using Human Leukocyte Antigen Typing and Whole‐Exome Sequencing [PDF]
Clinical and Translational AllergyBackground Cefaclor is a commonly prescribed β‐lactam antibiotic and a known major cause of immediate‐type drug hypersensitivity in Korea. However, its genetic risk factors remain poorly understood.
Sung‐Ryeol Kim +8 more
doaj +3 more sources
A Case of Staphylococcus aureus Septic Arthritis After COVID‐19 Vaccination [PDF]
Journal of General and Family MedicineSeptic arthritis is a serious medical emergency associated with high morbidity and mortality. A 49‐year‐old man with diabetes undergoing hemodialysis developed right shoulder pain and fever following his sixth dose of the COVID‐19 vaccine.
Mineto Ohta +4 more
doaj +3 more sources
Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects
Pharmaceutics, 2021 The aims of this study were: (1) to perform population pharmacokinetic analysis of cefaclor in healthy Korean subjects, and (2) to investigate possible effects of various covariates on pharmacokinetic parameters of cefaclor.
Seung-Hyun Jeong +2 more
exaly +3 more sources
In Vitro Activity of Cefaclor/Beta-Lactamases Inhibitors (Clavulanic Acid and Sulbactam) Combination Against Extended-Spectrum Beta-Lactamase Producing Uropathogenic E. coli [PDF]
AntibioticsBackground: Urinary tract infections (UTIs) caused by the multidrug resistance (MDR) phenotype termed extended-spectrum beta lactamase (ESBL)-producing E. coli is a significant and growing global health concern.
Ali Atoom +6 more
doaj +2 more sources
Preparation, molecular docking, and biological evaluation of radioiodinated cefaclor for inflammation detection [PDF]
BMC Pharmacology and ToxicologyBackground Inflammation serves as a natural defense mechanism; however, its persistence can lead to chronic diseases with serious clinical consequences.
H. Hussien +4 more
doaj +2 more sources
Highlighting the Role of Prenatally Administered Drugs in the Production of Dental Enamel Defects in Rats by Polarized Light Microscopy [PDF]
BiomedicinesBackground/Objectives: Although factors acting both prenatally and postnatally are taken into consideration, the etiopathogenesis of developmental defects of enamel (DDE) is not fully understood.
Mihai Popescu +9 more
doaj +2 more sources
HLA-DRB1 is associated with cefaclor-induced immediate hypersensitivity
World Allergy Organization JournalBackground: Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little is yet known about genetic biomarkers to
S-Y Park, Hyouk-Soo Kwon, David A Ostrov
exaly +3 more sources
Synthesis and characterization of divalent metal complexes of the macrocyclic ligand derived from isatin and 1,2-diaminobenzene [PDF]
Journal of the Serbian Chemical Society, 2011 A novel series of complexes of the type [M(C28H18N6)X2], where M=Co(II), Ni(II), Cu(II) or Zn(II) and X = Cl-, NO3- or CH3COO-, were synthesized by template condensation of isatin and 1,2-diaminobenzene in methanolic medium.
DHARAM PAL SINGH +3 more
doaj +2 more sources
Allergy, Asthma & Clinical Immunology, 2021 Background Cefaclor, a second-generation oral cephalosporin, is widely prescribed to treat infectious diseases. Immediate hypersensitivity (HS) reactions to cefaclor have continuously been reported and are expected to increase with its greater use.
Hyo-In Rhyou +8 more
doaj +1 more source
PLoS ONE, 2021 Cefaclor, a second-generation oral cephalosporin, is the most frequently prescribed cephalosporin in Korea. Studies, however, have yet to analyze the incidence of cefaclor-associated adverse drug reactions (ADRs), including hypersensitivity (HS ...
Hyo-In Rhyou +10 more
doaj +1 more source