Results 1 to 10 of about 104,609 (288)

Cephalosporin allergy: R1 side-chain and penicillin cross-reactivity patterns in an Australian cohort [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: Cross-reactivity between cephalosporins, and penicillins, is mainly explained by R1 side-chain similarity. However, data on cross-reactivity patterns in cephalosporin-allergic patients, with and without preexisting penicillin allergy labels ...
Brittany Stevenson, FRACP, FRCPA, Elizabeth Klinken, FRACP, FRCPA, Michelle Trevenen, PhD, Jack Bourke, FRACP, FRCPA, Patricia Martinez, PhD, FRACP, FRCPA, Michaela Lucas, Dr med, FRACP, FRCPA   +5 more
doaj   +2 more sources

Clinical Outcomes of Non-carbapenem Treatment for Urinary Tract Infections Caused by Extended-spectrum β-lactamase-producing [PDF]

Childhood Kidney Diseases, 2021
Purpose The purpose of this study was to investigate the clinical outcomes of non-carbapenem treatment for urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) in young children.
Eunae Kim, Yo Han Ahn, Jung Won Lee, Eujin Park   +3 more
doaj   +1 more source

Old and New Beta-Lactamase Inhibitors: Molecular Structure, Mechanism of Action, and Clinical Use

Antibiotics, 2021
The β-lactams have a central place in the antibacterial armamentarium, but the increasing resistance to these drugs, especially among Gram-negative bacteria, is becoming one of the major threats to public health worldwide.
Davide Carcione, Claudia Siracusa, Adela Sulejmani, Valerio Leoni, Jari Intra   +4 more
doaj   +1 more source

Status and Safety Signals of Cephalosporins in Children: A Spontaneous Reporting Database Study

Frontiers in Pharmacology, 2021
Introduction: Cephalosporins are widely used in clinical treatment of children, but it is difficult to carry out clinical trials and there is no strong evidence of their safety.
Yuanxuan Cai, Linhui Yang, Xiaofang Shangguan, Yuhang Zhao, Rui Huang   +4 more
doaj   +1 more source

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

Pathogens, 2021
Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute and chronic infections. β-lactam antibiotics including penicillins, carbapenems, monobactams, and cephalosporins play a key role in the treatment of P.
Karl A. Glen, Iain L. Lamont
doaj   +1 more source

In Vitro Activity of Cefiderocol against Extensively Drug-Resistant Pseudomonas aeruginosa: CANWARD, 2007 to 2019

Microbiology Spectrum, 2022
Cefiderocol was evaluated by broth microdilution versus 1,050 highly antimicrobial-resistant Pseudomonas aeruginosa clinical isolates from the CANWARD study (2007 to 2019).
James A. Karlowsky, Andrew J. Walkty, Melanie R. Baxter, Heather J. Adam, Philippe R. S. Lagacé-Wiens, Frank Schweizer, Denice Bay, Joseph P. Lynch, Michael R. Mulvey, George G. Zhanel   +9 more
doaj   +1 more source

Predicting Beta-Lactam Target Non-Attainment in ICU Patients at Treatment Initiation: Development and External Validation of Three Novel (Machine Learning) Models

Antibiotics, 2023
In the intensive care unit (ICU), infection-related mortality is high. Although adequate antibiotic treatment is essential in infections, beta-lactam target non-attainment occurs in up to 45% of ICU patients, which is associated with a lower likelihood ...
André Wieringa, Tim M. J. Ewoldt, Ravish N. Gangapersad, Matthias Gijsen, Nestor Parolya, Chantal J. A. R. Kats, Isabel Spriet, Henrik Endeman, Jasper J. Haringman, Reinier M. van Hest, Birgit C. P. Koch, Alan Abdulla   +11 more
doaj   +1 more source

Study on Thermodynamics and Kinetics of Cephalexin Enzymatic Hydrolysis and Its Process Development to Prepare 7-ADCA

Crystals, 2022
Cephalosporin enzymatic hydrolysis technology is a green technology for recovering 7-amino-3-deacetoxycephalosporanic acid (7-ADCA) from cephalosporin mother liquor. Solubility is critical for the production and purification of 7-ADCA. In this paper, the
Junli Zhang, Erhong Duan, Songgu Wu, Zeren Shang, Baohong Hou, Junbo Gong, Hua Sun   +6 more
doaj   +1 more source

It’s Not Easy Being Green: A Narrative Review on the Microbiology, Virulence and Therapeutic Prospects of Multidrug-Resistant Pseudomonas aeruginosa

Antibiotics, 2021
Pseudomonas aeruginosa is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients. These pathogens
Payam Behzadi, Zoltán Baráth, Márió Gajdács   +2 more
doaj   +1 more source

Construction of a Quantitative Structure Activity Relationship (QSAR) Model to Predict the Absorption of Cephalosporins in Zebrafish for Toxicity Study

Frontiers in Pharmacology, 2019
Cephalosporins are beta-lactam antibiotics that are widely used in China. Five generations of cephalosporins have been introduced in clinical practice to date; moreover, some new candidates are also undergoing clinical evaluations. To improve the success
Ying Liu, Xia Zhang, Jingpu Zhang, Changqin Hu   +3 more
doaj   +1 more source