Results 31 to 40 of about 137,963 (330)

Cefiderocol: A Novel Siderophore Cephalosporin Defeating Carbapenem-resistant Pathogens

Clinical Infectious Diseases, 2019
Cefiderocol, a novel siderophore cephalosporin in late-stage clinical development, utilizes a “Trojan horse” active transport mechanism to enter bacteria and has proven in vitro activity against carbapenem-resistant gram-negative pathogens, including ...
R. Bonomo
semanticscholar   +1 more source

ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases

Antimicrobial Agents and Chemotherapy, 2018
The activity of the siderophore cephalosporin cefiderocol is targeted against carbapenem-resistant Gram-negative bacteria. In this study, the activity of cefiderocol against characterized carbapenem-resistant Acinetobacter baumannii complex ...
Michael R. Jacobs, Ayman M. Abdelhamed, Caryn E. Good, Daniel D. Rhoads, Kristine M. Hujer, Andrea M. Hujer, T. Nicholas Domitrovic, S. Rudin, Sandra S. Richter, D. van Duin, Barry N. Kreiswirth, C. Greco, D. Fouts, R. Bonomo   +13 more
semanticscholar   +1 more source

High colonization rates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli [PDF]

, 2014
BACKGROUND International travel contributes to the worldwide spread of multidrug resistant Gram-negative bacteria. Rates of travel-related faecal colonization with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae vary for different ...
Battegay, Manuel, Widmer, Andreas F., Andreas Neumayr, Frei, Reno, Neumayr, Andreas, Hatz, Christoph, Jaeger, Veronika K., Veronika K Jaeger, Johannes Blum, Sabine Haller, Andreas F Widmer, Susan DeCrom, Blum, Johannes, Reno Frei, Furrer, Hansjakob, Endimiani, Andrea, Hansjakob Furrer, DeCrom, Susan, Jaeger, Veronika K, Haller, Sabine, Manuel Battegay, Andrea Endimiani, Esther Kuenzli, Widmer, Andreas F, Christoph Hatz, Kuenzli, Esther   +25 more
core   +3 more sources

Acute localized exanthematous pustulosis of the leg: A case report

JEADV Clinical Practice, 2023
We report a case of an unusually located site of acute localized exanthematous pustulosis in the right lower limb of a patient treated with beta‐lactams which resolved upon cessation. This case report highlights the need for vigilance as well as an index
Wen Shuo Tiong, Sean Leong, Wei‐Sheng Chong   +2 more
doaj   +1 more source

Differential active site requirements for NDM-1 β-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics

Nature Communications, 2018
New Delhi metallo-β-lactamase-1 exhibits a broad substrate profile for hydrolysis of the penicillin, cephalosporin and ‘last resort’ carbapenems, and thus confers bacterial resistance to nearly all β-lactam antibiotics.
Zhi-Zeng Sun, Li-Ya Hu, B. Sankaran, B. V. Venkataram Prasad, T. Palzkill   +4 more
semanticscholar   +1 more source

The Association Between Cephalosporin and Hypoprothrombinemia: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health, 2019
Cephalosporins that contain the N-methylthiotetrazole side chain (NMTT-cephalosporin) have been reported to be associated with coagulation-related adverse events; however, a comprehensive evaluation regarding the association is lacking.
G. H. Park, Seungyeon Kim, Min Soo Kim, Y. Yu, Gun-Hee Kim, Jeong Sang Lee, Euni Lee   +6 more
semanticscholar   +1 more source

Cephalosporin allergy label is misleading [PDF]

, 2018
Penicillins and cephalosporins can cause a similar spectrum of allergic reactions at a similar rate. Cross-reactive allergy between penicillins and cephalosporins is rare, as is cross-reaction within the cephalosporin group. Patients should therefore not
Smith, William B., Katelaris, Constance H. (R12307), Constance H Katelaris, Yuson, Carlo L., Carlo L Yuson, William B Smith   +5 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Insights into the Versatility of Using Atomic Absorption Spectrometry in Antibacterial Research

Molecules
The ongoing development of bacterial resistance to antibiotics is a global challenge. Research in that field is thus necessary. Analytical techniques are required for such a purpose. From this perspective, the focus was on atomic absorption spectrometry (
David Krüger, James T. P. Matshwele, Muhammad Dauda Mukhtar, Daniel Baecker   +3 more
doaj   +1 more source

Detection of Cephalosporin and Fluoroquinolone Resistance Genes via Novel Multiplex qPCR in Fecal Salmonella Isolates From Northern Californian Dairy Cattle, 2002–2016

Frontiers in Microbiology, 2021
The objectives of this study were to evaluate the prevalence of extended spectrum β-lactamase (ESBL) genes, AmpC-type β-lactamase (ACBL) genes, and plasmid mediated quinolone resistance (PMQR) genes in Salmonella isolated at a Veterinary Medical Teaching
Carl Basbas, Barbara A. Byrne, Munashe Chigerwe, Edlin D. Escobar, Emir Hodzic, Alda F. A. Pires, Richard V. Pereira   +6 more
doaj   +1 more source