Results 51 to 60 of about 137,963 (330)

Successful Outcome of Severe Intra-cerebral Bleeding Associated with Acquired Factor V Inhibition: Utilization of Multiple Therapeutic Agents

Balkan Medical Journal, 2018
A 78-year-old male presented to the emergency department due to repeated episodes of syncope over the last 3 days. Physical examination during admission revealed pallour and extensive ecchymosis in his left hemithorax and left thigh.
Panagiotis Andreadis, Katerina Kafantari, Aleka Agapidou, Sofia Vakalopoulou, Efthymia Vlachaki   +4 more
doaj   +1 more source

The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis

Nature Communications, 2017
New Delhi metallo-β-lactamases (NDMs), the recent additions to metallo-β-lactamases (MBLs), pose a serious public health threat due to its highly efficient hydrolysis of β-lactam antibiotics and rapid worldwide dissemination.
Han Feng, Xue-Hui Liu, Sheng Wang, Joy Fleming, Da-Cheng Wang, Wei Liu   +5 more
semanticscholar   +1 more source

Substrate entering and product leaving trajectories predict an engulfing dynamic for the major conformational change of the β-lactam acylase [PDF]

, 2008
It is still a major challenge to acquire insight into the conformational changes between the ground state and the transition state of an enzyme, although conformational fluctuation within interconverting conformers has been widely investigated (1-4 ...
Xi Huang, Jun Yin, Wei-Hong Jiang, Zixin Deng, Guo-Ping Zhao   +4 more
core  

Characterization of CTX-M-14-producing Escherichia coli from food-producing animals

Frontiers in Microbiology, 2015
Bacterial resistance to the third-generation cephalosporin antibiotics has become a major concern for public health. This study was aimed to determine the characteristics and distribution of blaCTX-M-14, which encodes an extended-spectrum β-lactamase, in
Xiao-Ping eLiao, Jing eXia, Lei eYang, Liang eLi, Jian eSun, Ya-Hong eLiu, Ya-Hong eLiu, Hong-Xia eJiang   +7 more
doaj   +1 more source

Incidence of cephalosporin‐induced anaphylaxis and clinical efficacy of screening intradermal tests with cephalosporins: A large multicenter retrospective cohort study

Allergy. European Journal of Allergy and Clinical Immunology, 2018
Few studies have investigated the incidence of anaphylaxis induced by individual or structurally similar cephalosporins. The aims of the study were to assess the incidence of cephalosporin‐induced anaphylaxis and evaluate the clinical efficacy of ...
M.-S. Yang, D. Kang, B. Seo, H. J. Park, S.-Y. Park, M.-Y. Kim, K. H. Park, S. Koo, Y. Nam, S. Kim, J.-W. Jung, T-B Kim, G. Jang, H.-J. Yang, Y. Ahn, J.-W. Park, H.-R. Kang   +16 more
semanticscholar   +1 more source

Comparative analysis of the pathogenicity between multidrug-resistant Acinetobacter baumannii clinical isolates: isolation of highly pathogenic multidrug-resistant A. baumannii and experimental therapeutics with fourth-generation cephalosporin cefozopran

Infection and Drug Resistance, 2018
Satoshi Nishida, Yasuo Ono Department of Microbiology and Immunology, Teikyo University School of Medicine, Itabashi, Tokyo, Japan Introduction: The pathogenicity of fatal-outbreak Acinetobacter baumannii isolates has not been fully investigated.
Nishida S, Ono Y
doaj  

Cephalosporin Induced Toxic Epidermal Necrolysis and Subsequent Penicillin Drug Exanthem

Allergology International, 2008
Background: Drug hypersensitivity is classically divided into IgE mediated and non-IgE mediated disease. We report a rare case of consequent IgE mediated and non-IgE mediated reactions within the beta lactam class of antibiotics. Case Summary: An 84-year-
Amanda Lam, Inderpal Randhawa, William Klaustermeyer   +2 more
doaj   +1 more source

Repurposing Cefazolin-Avibactam for the Treatment of Drug Resistant Mycobacterium tuberculosis

Frontiers in Pharmacology, 2021
Background: While tuberculosis (TB) is curable and preventable, the most effective first-line antibiotics cannot kill multi-drug resistant (MDR) Mycobacterium tuberculosis (Mtb).
Shashikant Srivastava, Shashikant Srivastava, Shashikant Srivastava, Tawanda Gumbo, Tania Thomas   +4 more
doaj   +1 more source

THE ENZYMATIC CONVERSION OF EXOMETHYLENE CEPHALOSPORIN-C INTO DEACETYL CEPHALOSPORIN-C AND THE ROLE OF MOLECULAR-OXYGEN IN CEPHALOSPORIN-C BIOSYNTHESIS

, 1988
Cell free extracts from Cephalosporium acremonium containing deaoetoxy/-deacetyl cephalosporin C Synthetase activities have been shown to convert Exomethylene cephalosporin C directly to deacetyl cephalosporin C.
ADLINGTON, R, CROUCH, N, SCHOFIELD, C, Jack E. Baldwin, Robert M. Adlington, Nicholas P. Crouch, Christopher J. Schofield, BALDWIN, J   +7 more
core   +1 more source

Effect of inoculum size on the antibiotic susceptibilities of β-lactamase positive isolates of Moraxella catarrhalis [PDF]

Medicinski Glasnik, 2005
It is well known that bacteria producing β-lactamases in general show marked inoculum effect in susceptibility testing. The aim of this study is to determine the effect of inoculum size on the susceptibility of β-lactamase positive strains of M ...
J. Vraneš, B. Bedenić
doaj