Results 71 to 80 of about 137,963 (330)

Cephalosporin allergy: R1 side-chain and penicillin cross-reactivity patterns in an Australian cohort

Journal of Allergy and Clinical Immunology: Global
Background: Cross-reactivity between cephalosporins, and penicillins, is mainly explained by R1 side-chain similarity. However, data on cross-reactivity patterns in cephalosporin-allergic patients, with and without preexisting penicillin allergy labels ...
Brittany Stevenson, FRACP, FRCPA, Elizabeth Klinken, FRACP, FRCPA, Michelle Trevenen, PhD, Jack Bourke, FRACP, FRCPA, Patricia Martinez, PhD, FRACP, FRCPA, Michaela Lucas, Dr med, FRACP, FRCPA   +5 more
doaj   +1 more source

Extrapolation and pharmacokinetic protocol design optimization for ceftriaxone as an exemplar for the development of antibiotics for children

British Journal of Clinical Pharmacology, EarlyView.
Aim Ceftriaxone is a cephalosporin commonly used for the treatment of acute, severe infections; however, there are conflicting data on its disposition properties in children, making it a suitable case study for the evaluation of the appropriateness of extrapolation approaches based on exposure matching principles for paediatric patients and exploring ...
Daniel Valente Neves, Umberto Villani, Salvatore D'Agate, Sean Oosterholt, Ricardo de Carvalho Cavalli, Fabio Carmona, Vera Lucia Lanchote, Oscar Della Pasqua   +7 more
wiley   +1 more source

Simulating an intravenous-to-oral cefotaxime-to-cefditoren/cefuroxime switch: an in vitro pharmacodynamic approach against selected Streptococcus pneumoniae strains with defined susceptibility profiles

Frontiers in Pharmacology
IntroductionThe lack of oral equivalent for third-generation IV cephalosporins challenges sequential cephalosporin therapy for pneumococcal infections. This in vitro study combined the previously reported pharmacokinetics of IV cefotaxime (CTX) and oral ...
Natalia González, Eva Manceras Jiménez, María José Giménez, Luis Alou, Pilar Coronel, Elena Gómez-Rubio, María Luisa Gómez-Lus, David Sevillano   +7 more
doaj   +1 more source

Emergence of Ceftriaxone-Resistant Salmonella Isolates and Rapid Spread of Plasmid-Encoded CMY-2–Like Cephalosporinase, Taiwan

Emerging Infectious Diseases, 2003
Of 384 Salmonella isolates collected from 1997 to 2000 in a university hospital in Taiwan, six ceftriaxone-resistant isolates of Salmonella enterica serovar Typhimurium were found in two patients in 2000.
Jing-Jou Yan, Wen-Chien Ko, Cheng-Hsun Chiu, Shu-Huei Tsai, Hsiu-Mei Wu, Jiunn-Jong Wu   +5 more
doaj   +1 more source

Cephalosporin-3'-diazeniumdiolate NO donor prodrug PYRRO-C3D enhances azithromycin susceptibility of nontypeable Haemophilus influenzae biofilms

, 2017
PYRRO-C3D is a cephalosporin-3-diazeniumdiolate nitric oxide (NO) donor prodrug designed to selectively deliver NO to bacterial infection sites.
Ardeshir Rineh (20121465), Saul Faust (6313958), Woolf Walker (4913245), Raymond Allan (20215053), Michael Kelso (19588105), Samuel Collins (3466118), Gary Connett (8333250), Claire Jackson (362873), Jane Lucas (2822975), Martin Feelisch (358503), Luanne Hall-Stoodley (588643), Nageshwar Rao Yepuri (20117190), Jeremy Webb (625757), Georgia Halladay (20229834), Janice Coles (11474895)   +14 more
core   +1 more source

Cephalosporin-resistant Pneumococci and Sickle Cell Disease

, 2005
Sickle cell anemia patients have 600 times the risk for invasive pneumococcal disease than their healthy peers. High-level cephalosporin resistance was described in the 1990s in healthy children from Tennessee, but its prevalence in sickle cell disease ...
Najat C. Daw, Martha L. Miller, Caroline A. Obert, Patricia Flynn, Elaine Tuomanen, Geli Gao   +5 more
core   +1 more source

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

Cefepime Efficacy and Safety in Children: A Systematic Review and Meta-analysis

Frontiers in Pediatrics, 2018
BackgroundCefepime is a fourth-generation cephalosporin antibiotic used to treat a variety of infections. The US Food and Drug Administration approved its use in certain types of infections among pediatric patients, and yet there have been mixed data ...
Saber Jan, Saber Jan, Braveen Ragunanthan, Sandra R. DiBrito, Omolabake Alabi, Maria Gutierrez   +5 more
doaj   +1 more source

Cefepime exposure in prolonged or intermittent infusion in critically ill children

British Journal of Clinical Pharmacology, EarlyView.
Aims Cefepime is commonly used in critically ill children for whom there is a high between‐subject variability. To reach the therapeutic pharmacokinetic (PK) target in critically ill patients, prolonged infusion of beta‐lactams seems to be the most efficient.
Marc Hobeika, Deborah Hirt, Emmanuelle Bille, Sihem Benaboud, Julie Toubiana, Pierre‐Louis Léger, Jérôme Rambaud, Agathe Béranger, Delphine Callot, Sylvain Renolleau, Jean‐Marc Treluyer, Mehdi Oualha, Noémie de Cacqueray   +12 more
wiley   +1 more source

Pharmacokinetics, safety, and tolerability of HRS-8427, a novel anti-carbapenem-resistant cephalosporin, in healthy subjects

Antimicrobial Agents and Chemotherapy
HRS-8427 is a novel parenteral siderophore cephalosporin that shows potent efficacy against various gram-negative bacteria, including carbapenem-resistant strains, in vitro and in preclinical models of infection.
Tengrui Yin, Biao Qu, Qian Zhang, Sheng Xu, Yijue Wu, Hao Jiang, Yuanyuan Huang, Wei Hu   +7 more
doaj   +1 more source