Results 61 to 70 of about 47,760 (259)

Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation

Advanced Science, EarlyView.
Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu, Xin Yuan, Zilong He, Hong Jin, Jiayi Tian, Cong Chen, Yuanjing Liu, Xiang Zhang, Shidan Wen, Emilio Kropff, Chenglin Miao   +10 more
wiley   +1 more source

Prolonged efficacy of cefazolin in intraosseous regional prophylaxis for total knee arthroplasty: a rabbit model study

BMC Musculoskeletal Disorders
Background A novel approach known as intraosseous regional administration (IORA) has emerged as a technique for delivering prophylactic antibiotics, and it results in higher tissue concentrations around the knee. It is hypothesized that IORA of cefazolin
Jing-Yu Zhang, Ling-Chen Ye, Yu-bo Liu, Xiao Yu, Xiang-Xin Zhang, Guang-Xiang Chen, Ren-Jie Xu   +6 more
doaj   +1 more source

Arthroscopy‐Assisted Type 2 Posterior Horn Lateral Meniscus Transtibial Root Repair And Concurrent Inside‐Out Lateral Meniscus Horizontal Cleavage Tear Repair With an Anterolateral Ligament Reconstruction Utilizing Iliotibial Band Autograft

Arthroscopy Techniques, EarlyView.
Abstract The anterior cruciate ligament (ACL) and anterolateral ligament (ALL) play key roles in maintaining rotational stability of the knee joint. Injuries that cause ACL tears have been shown to also frequently compromise the integrity of the ALL.
Taidhgin J. Keel, Benjiman J. Wilebski, Luke V. Tollefson, Ethan R. Sawyer, Taylor J. Freetly, Christopher M. LaPrade, Robert F. LaPrade   +6 more
wiley   +1 more source

Arthroscopic Latissimus Dorsi Transfer in the Lateral Decubitus Position for Irreparable Posterosuperior Massive Rotator Cuff Tears

Arthroscopy Techniques, EarlyView.
Abstract The management of irreparable posterosuperior massive rotator cuff tears remains challenging. With advances in arthroscopic techniques, minimally invasive arthroscopic latissimus dorsi tendon (LDT) transfer has been increasingly used for irreparable posterosuperior massive rotator cuff tears.
Yang Yang, JianMin Zhang, Peng Wang, QingGuo Zhang, YongZhi Ye, XiaoBo Zhou   +5 more
wiley   +1 more source

Comparative Effectiveness of Ampicillin/Sulbactam versus Cefazolin as Targeted Therapy for Bacteremia Caused by Beta-Lactamase-Producing Methicillin-Sensitive Staphylococcus aureus: A Single-Center Retrospective Study

Antibiotics, 2022
Cefazolin (CFZ) is the first-line treatment for beta-lactamase-producing methicillin-sensitive Staphylococcus aureus (BP-MSSA) infection. In 2019, Japan experienced a CFZ shortage because of foreign object inclusion in a batch. Ampicillin/sulbactam (SAM)
Jun Hirai, Nobuhiro Asai, Mao Hagihara, Takaaki Kishino, Hideo Kato, Daisuke Sakanashi, Wataru Ohashi, Hiroshige Mikamo   +7 more
doaj   +1 more source

Current practice and guideline adherence in renal dose adjustment for patients with chronic kidney disease: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims To quantify prescribing adherence to renal dosing recommendations in adults with chronic kidney disease (CKD; Stage 3 and above) and to evaluate the clinical consequences of non‐adherence. Methods This systematic review and meta‐analysis was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD42025620883).
Hager ElGeed, Ahmed Tehemar, Mohamed Gasimelseed, Ahmed Gharaibeh, Muhammad Abdul Hadi, Kazeem Yusuff, Amani Zidan, Ahmed Awaisu   +7 more
wiley   +1 more source

A Novel Gelatin Hydrogel-Based Drug-Delivery System Promotes Antimicrobial Efficacy in a Pyogenic Spondylodiscitis Rat Model. [PDF]

JOR Spine
ABSTRACT Background Spondylodiscitis/spondylitis is an intractable disease requiring long‐term intravenous antibiotics administration. However, drug delivery is greatly restricted because of the avascular nature in the intervertebral disc, which not only delays recovery but increases antimicrobial resistance and osteomyelitis. The purpose of this study
Miyazaki K, Kanda Y, Yurube T, Takeoka Y, Tsujimoto T, Ohnishi H, Matsuo T, Ryu M, Kumagai N, Kuroshima K, Hiranaka Y, Tabata Y, Kuroda R, Kakutani K.   +13 more
europepmc   +2 more sources

Pharmacokinetics of intraperitoneal cefalothin and cefazolin in patients being treated for peritoneal dialysis-associated peritonitis

, 2016
Background: The standard treatment of peritoneal dialysis (PD)-associated peritonitis (PD-peritonitis) is intraperitoneal (IP) administration of antibiotics.
Wallis, SC, Varghese, JM, Ranganathan, D, Varghese, Julie M., Roberts, DM, Kark, A, Roberts, Darren M., Kark, Adrian, Lipman, Jeffrey, Roberts, JA, Wallis, Steven C., Ranganathan, Dwarakanathan, Roberts, Jason A., Lipman, J   +13 more
core   +1 more source

Cefepime exposure in prolonged or intermittent infusion in critically ill children

British Journal of Clinical Pharmacology, EarlyView.
Aims Cefepime is commonly used in critically ill children for whom there is a high between‐subject variability. To reach the therapeutic pharmacokinetic (PK) target in critically ill patients, prolonged infusion of beta‐lactams seems to be the most efficient.
Marc Hobeika, Deborah Hirt, Emmanuelle Bille, Sihem Benaboud, Julie Toubiana, Pierre‐Louis Léger, Jérôme Rambaud, Agathe Béranger, Delphine Callot, Sylvain Renolleau, Jean‐Marc Treluyer, Mehdi Oualha, Noémie de Cacqueray   +12 more
wiley   +1 more source

Challenges for interpreting results of antimicrobial susceptibility testing for treating infections of foals with Rhodococcus equi

Equine Veterinary Journal, EarlyView.
Abstract Rhodococcus equi is a facultative intracellular pathogen and a major cause of pneumonia in foals worldwide. The standard treatment for affected foals is a combination of a macrolide with rifampicin. The widespread use of this combination has led to the emergence of multidrug‐resistant (MDR) strains of R. equi.
Marlane Geribone Seeger, Letícia Trevisan Gressler, Laura Huber, Sonsiray Alvarez‐Narvaez, Juliana Felipetto Cargnelutti, Angela Ilha Bordin, Sara D. Lawhon, Noah D. Cohen   +7 more
wiley   +1 more source