Results 41 to 50 of about 47,760 (259)

Pharmacodynamic Evaluation of a Single Dose versus a 24-Hour Course of Multiple Doses of Cefazolin for Surgical Prophylaxis

, 2021
The optimal perioperative duration for the administration of cefazolin and other prophylactic antibiotics remains unclear. This study aimed to describe the pharmacodynamics of cefazolin for a single 2 g dose versus a 24 h course of a 2 g single dose plus
Roberts, Jason A, Adiraju, Santosh, Heffernan, Aaron, Sime, Fekade Bruck, Saiyuri Naicker, Jowana Alawie, Aaron Heffernan, Naicker, Saiyuri, Steven C Wallis, Wallis, Steven C, Santosh Adiraju, Alawie, Jowana, Jason A. Roberts, Fekade Bruck Sime   +13 more
core   +1 more source

Preoperative administration of cephalosporins for elective caesarean delivery [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2010
Introduction. Antibiotic prophylaxis means administration of antibiotics in prevention of infections. Objective. To investigate the efficacy of a single dose preoperative administration of ceftriaxone and cefazolin in the prevention of intra- and ...
Bogavac Mirjana, Grujić Ilija, Grujić Zorica, Popović Jovan   +3 more
doaj   +1 more source

Cefazolin Monotherapy Versus Cefazolin Plus Aminoglycoside for Antimicrobial Prophylaxis of Type III Open Fractures

, 2020
A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.Background: There are conflicting recommendations between organizations regarding aminoglycoside
Meshay, Ian
core   +1 more source

Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid.

Journal of Antimicrobial Chemotherapy, 2021
OBJECTIVES To assess plasma and tissue pharmacokinetics of cefazolin and metronidazole in obese patients undergoing bariatric surgery and non-obese patients undergoing intra-abdominal surgery.
C. Dorn, D. Petroff, Melanie Stoelzel, M. G. Kees, A. Kratzer, A. Dietrich, C. Kloft, M. Zeitlinger, F. Kees, H. Wrigge, P. Simon   +10 more
semanticscholar   +1 more source

Intraoperative Redosing of Cefazolin and Risk for Surgical Site Infection in Cardiac Surgery

Emerging Infectious Diseases, 2001
Intraoperative redosing of prophylactic antibiotics is recommended for prolonged surgical procedures, although its efficacy has not been assessed. We retrospectively compared the risk of surgical site infections in 1,548 patients who underwent cardiac ...
Giorgio Zanetti, Richard Giardina, Richard Platt   +2 more
doaj   +1 more source

Cloxacillin versus cefazolin for meticillin-susceptible Staphylococcus aureus bacteraemia (CloCeBa): a prospective, open-label, multicentre, non-inferiority, randomised clinical trial.

The Lancet
BACKGROUND Although widely used, cefazolin efficacy for the treatment of meticillin-susceptible Staphylococcus aureus (MSSA) bacteraemia has not thus far been investigated in a clinical trial. In this study, we aimed to compare the efficacy and safety of
C. Burdet, Nadia Saïdani, C. Dupieux, A. Lemaignen, E. Canouï, Laure Surgers, M. Vareil, A. Lefort, R. Lepeule, N. Peiffer-Smadja, A. Charmillon, V. Le Moing, D. Boutoille, V. Tolsma, Sophie Abgrall, M. Wolff, P. Tattevin, M. Esposito-farese, F. Vandenesch, Xavier Duval, S. Tubiana, F. Lescure   +21 more
semanticscholar   +1 more source

Pharmacokinetic Evaluation of Cefazolin in the Cerebrospinal Fluid of Critically Ill Patients

Open Forum Infectious Diseases, 2021
Background The relative distribution of cefazolin into the cerebrospinal fluid (CSF) remains debated. Determining the distribution of cefazolin into the CSF in noninfected adults may allow for further treatment applications of cefazolin. This prospective
Alison R. Novak, Martin Kršák, T. Kiser, Robert T. Neumann, Luis Cava Prado, Kyle C. Molina, S. Mueller   +6 more
semanticscholar   +1 more source

Corrosion Inhibition of Expired Cefazolin Drug on Copper Metal in Dilute Hydrochloric Acid Solution: Practical and Theoretical Approaches

Molecules
In this work, we studied the corrosion of Cu metal in 0.5 mol L−1 HCl and the inhibition effect of the expired Cefazolin drug. The inhibition efficiency (IE) of Cefazolin varied according to its concentration in solution.
Raiedhah A. Alsaiari, M. Kamel, M. M. Mohamed   +2 more
semanticscholar   +1 more source

A Test for the Rapid Detection of the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus

Journal of Clinical Microbiology, 2021
The cefazolin inoculum effect (CzIE) has been associated with therapeutic failures and mortality in invasive methicillin-susceptible Staphylococcus aureus (MSSA) infections. A diagnostic test to detect the CzIE is not currently available.
Sandra L. Rincon, L. Carvajal, S. Gomez-Villegas, Aura M. Echeverri, Rafael Ríos, An Q. Dinh, C. Pedroza, Karen Ordóñez, E. Nannini, Zhi-Zeng Sun, V. Fowler, B. Murray, William R. Miller, T. Palzkill, L. Díaz, C. Arias, Jinnethe Reyes   +16 more
semanticscholar   +1 more source

Inoculum Effect With Cefazolin Among Clinical Isolates of Methicillin-Susceptible Staphylococcus Aureus: Frequency and Possible Cause of Cefazolin Treatment Failure [PDF]

, 2009
Methicillin (meticillin)-susceptible Staphylococcus aureus (MSSA) strains producing large amounts of type A beta-lactamase (Bla) have been associated with cefazolin failures, but the frequency and impact of these strains have not been well studied.
G. R. Corey, Rude, Tom H, Murray, Barbara E, Singh, Kavindra V, K. V. Singh, T. H. Rude, B. E. Murray, V. G. Fowler, A. Bourgogne, Bourgogne, Agathe, Nannini, Esteban C, Stryjewski, Martin E, Fowler, Vance G, Corey, G Ralph, E. C. Nannini, M. E. Stryjewski   +15 more
core   +1 more source