Results 31 to 40 of about 47,760 (259)

Reducing Surgical Site Infection and Sepsis after Hysterectomy: Cefazolin Compared with Cefazolin Plus Metronidazole [PDF]

, 2022
Study Objective: To evaluate if cefazolin plus metronidazole before a hysterectomy will be more effective in prevention of surgical site infection (SSI) and sepsis compared to the existing recommendation of preoperative cefazolin alone.
Todter, Erika, Swain, Monique, Arun, Janhavi L, Shalabi, Firas   +3 more
core   +1 more source

Deranged Coagulation Profile Secondary to Cefazolin Use: Case Report

Infectious Disease Reports, 2021
Cefazolin is a widely used first-generation cephalosporin. While generally well tolerated, several case reports have described severe coagulopathy induced by intravenous (IV) cefazolin. This was seen particularly in patients with impaired renal function,
Jinghao Nicholas Ngiam, Tze Sian Liong, Sai Meng Tham, Thanawin Pramotedham, Rawan AlAgha, Joy Yong, Paul Anantharajah Tambyah, Lionel Hon Wai Lum   +7 more
doaj   +1 more source

Prevalence of a cefazolin inoculum effect associated with blaZ gene types, and clinical outcomes among methicillin-susceptible Staphylococcus aureus blood isolates of patients with infective endocarditis.

Infectious Diseases Now, 2022
OBJECTIVES A proportion of blaZ gene-positive methicillin-susceptible Staphylococcus aureus (MSSA) strains exhibits the cefazolin inoculum effect (CInE).
A. Bourreau, V. Le Mabecque, A. Broquet, J. Caillon   +3 more
semanticscholar   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice

Journal of Neuroinflammation, 2018
Background Emerging evidence indicates that long-time use of multiple antibiotics can induce cognitive dysfunction via gut dysbiosis. Cefazolin is often used for 3 to 5 days to prevent perioperative infection.
Peng Liang, Weiran Shan, Zhiyi Zuo
doaj   +1 more source

Cefazolin in the treatment of central nervous system infections: A narrative review and recommendation

Pharmacotherapy, 2022
Infections of the central nervous system (CNS) are complex to treat and associated with significant morbidity and mortality. Historically, antistaphylococcal penicillins such as nafcillin were recommended for the treatment of methicillin‐susceptible ...
Kayla Antosz, Sarah E. Battle, Jack Chang, Marc H. Scheetz, M. Al-Hasan, P. Bookstaver   +5 more
semanticscholar   +1 more source

Definitive Cefazolin Treatment for Community-Onset Enterobacteriaceae Bacteremia Based on the Contemporary CLSI Breakpoint: Clinical Experience of a Medical Center in Southern Taiwan

Antibiotics, 2019
Cefazolin is traditionally active against Escherichia coli, Klebsiella species, and Proteus mirabilis (EKP) isolates. The Clinical and Laboratory Standards Institute (CLSI) has twice updated cefazolin susceptibility breakpoints for EKP since 2010, but ...
Ching-Chi Lee, Chung-Hsun Lee, Po-Lin Chen, Chih-Chia Hsieh, Hung-Jen Tang, Wen-Chien Ko   +5 more
doaj   +1 more source

Impact of Cefazolin Shortage on Clinical Outcomes of Adult Patients with Bacteremia Caused by Methicillin-Susceptible Staphylococcus aureus in a Tertiary Care University Hospital

Antibiotics, 2021
Cefazolin is an essential antibiotic used for treating bacteremia; in particular, it is recommended as a first-line agent for infections caused by methicillin-susceptible Staphylococcusaureus (MSSA).
Atsushi Uda, Kenichiro Onuma, Katsumi Shigemura, Koichi Kitagawa, Yonmin Yan, Kayo Osawa, Ikuko Yano, Takayuki Miyara   +7 more
doaj   +1 more source

Cefazolin Improves Anesthesia and Surgery-Induced Cognitive Impairments by Modulating Blood-Brain Barrier Function, Gut Bacteria and Short Chain Fatty Acids

Frontiers in Aging Neuroscience, 2021
Emerging evidence suggests that anesthesia and surgery may induce gut dysbiosis. Gut dysbiosis leads to imbalance in circulating contents of microbiota-derived metabolites and disrupts the integrity of the blood-brain barrier (BBB), contributing to ...
A. Luo, Shan Li, Xuan Wang, Zheng Xie, Shi-Yong Li, Dong-Yu Hua   +5 more
semanticscholar   +1 more source

Bioanalytical development and validation of liquid chromatographic–tandem mass spectrometric methods for the quantification of total and free cefazolin in human plasma and cord blood

Practical Laboratory Medicine, 2015
Objectives: Cefazolin is a commonly prescribed β-lactam antibiotic for prophylaxis against skin infections following surgery, including caesarean sections.
Christopher A. Crutchfield, Mark A. Marzinke   +1 more
doaj   +1 more source