Results 11 to 20 of about 47,760 (259)

Safety of Cefazolin in Prophylaxis in Β-Lactam Allergic Children

open access: yesBezmiâlem Science, 2022
Objective:Cefazolin is a first-generation cephalosporin, particularly effective against gram positive agents such as staphylococci and streptococci. Despite this narrow spectrum, it is important in surgical prophylaxis.
Ayşe SÜLEYMAN   +3 more
doaj   +2 more sources

Gelatin Methacryloyl Hydrogels for the Localized Delivery of Cefazolin

open access: yesPolymers, 2021
The tuneability of hydrogels renders them promising candidates for local drug delivery to prevent and treat local surgical site infection (SSI) while avoiding the systemic side-effects of intravenous antibiotic injections.
Margaux Vigata   +5 more
semanticscholar   +3 more sources

Cefazolin Concentration in the Mediastinal Adipose Tissue of Patients Undergoing Cardiac Surgery

open access: yesBrazilian Journal of Cardiovascular Surgery, 2017
Objective: To measure the concentration of cefazolin in the anterior mediastinal adipose tissue of patients undergoing cardiac surgery, determining the variation of cefazolin concentration. Methods: Two samples of approximately 1g of subcutaneous tissue
Rodrigo Mezzalira Tchaick   +5 more
doaj   +3 more sources

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort [PDF]

open access: yes, 2023
Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal ...
Francisco Javier González Moraga   +812 more
core   +1 more source

Cefazolin vs Second-line Antibiotics for Surgical Site Infection Prevention After Total Joint Arthroplasty Among Patients With a Beta-lactam Allergy

open access: yesOpen Forum Infectious Diseases, 2023
Background Cefazolin is a first-line agent for prevention of surgical site infections (SSIs) after total joint arthroplasty. Patients labeled allergic to beta-lactam antibiotics frequently receive clindamycin or vancomycin perioperatively due to the ...
Miranda R Norvell   +7 more
semanticscholar   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Cefazolin Using Total and Unbound Serum Concentrations in Patients with High Body Weight.

open access: yesInternational Journal of Antimicrobial Agents, 2023
The study objective was to evaluate the steady-state pharmacokinetics and pharmacodynamics of cefazolin in patients with large body weight. Cefazolin was administered by 0.5-h infusions to 11 patients with a total body weight (TBW) ≥ 120 kg (TBW≥120 ...
E. Chung   +9 more
semanticscholar   +1 more source

Assessment of the Frequency of Dual Allergy to Penicillins and Cefazolin: A Systematic Review and Meta-analysis.

open access: yesJAMA Surgery, 2021
Importance Cefazolin is the preoperative antibiotic of choice because it is safer and more efficacious than second-line alternatives. Surgical patients labeled as having penicillin allergy are less likely to prophylactically receive cefazolin and more ...
B. Sousa-Pinto   +4 more
semanticscholar   +1 more source

The issue beyond resistance: Methicillin-resistant Staphylococcus epidermidis biofilm formation is induced by subinhibitory concentrations of cloxacillin, cefazolin, and clindamycin

open access: yesPLoS ONE, 2022
Staphylococcus epidermis is one of the most frequent causes of device-associated infections due to biofilm formation. Current reports noted that subinhibitory concentrations of antibiotics induce biofilm production in some bacteria.
Rasoul Mirzaei   +4 more
semanticscholar   +1 more source

Application of a Physiologically Based Pharmacokinetic Model to Predict Cefazolin and Cefuroxime Disposition in Obese Pregnant Women Undergoing Caesarean Section

open access: yesPharmaceutics, 2022
Intravenous (IV) cefuroxime and cefazolin are used prophylactically in caesarean sections (CS). Currently, there are concerns regarding sub-optimal dosing in obese pregnant women compared to lean pregnant women prior to CS.
Hanadi H. Alrammaal   +6 more
doaj   +1 more source

Antimicrobial activity of impregnated antibiotic matrix materials for bone tissue defect reconstruction [PDF]

open access: yesArchives of the Balkan Medical Union, 2020
Introduction. Combinations of fibrous materials with therapeutic agents as a drug delivery system are currently studied. A new direction has appeared in reconstructive surgery – tissue engineering, which aims to restore biological functions, i.e.
Andrii V. PANTUS   +4 more
doaj   +1 more source

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