Results 41 to 50 of about 49,774 (199)

Susceptibility Provision Enhances Effective De-escalation (SPEED): utilizing rapid phenotypic susceptibility testing in Gram-negative bloodstream infections and its potential clinical impact [PDF]

, 2019
Objectives We evaluated the performance and time to result for pathogen identification (ID) and antimicrobial susceptibility testing (AST) of the Accelerate Pheno™ system (AXDX) compared with standard of care (SOC) methods.
Blevins, Sarah, Bocian, Brittany, Davis, Thomas E., Desai, Armisha, Emery, Christopher L., Hiles, Jon, Manaloor, John J., Schmitt, Bryan H., Schneider, Jack G., Smith, Nathan W., Wood, James B., Wrin, Justin   +11 more
core   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Comparative Analysis of the Effectiveness of Generic and Brand-Name Cefepime: A Multicenter Retrospective Cohort Study

Life
The clinical effectiveness of generic and brand-name cefepime in real-world settings remains unclear. Given the potential implications for healthcare costs and patient outcomes, this study aims to compare the efficacy and safety of these two formulations.
Chih-Huang Li, Peng-Hao Chang, Ching-Tai Huang, Chip-Jin Ng   +3 more
doaj   +1 more source

Assessing the association between cefepime percentage free trough level and neurotoxicity

Antimicrobial Stewardship & Healthcare Epidemiology, 2022
Background: Cefepime has a known association with neurotoxicity due to its ability to cross the blood–brain barrier. The symptoms of neurotoxicity are highly variable.
Aleena Zia, Armisha Desai, Molly Tieman, Haley Pritchard   +3 more
doaj   +1 more source

Development and implementation of a computerised clinical decision support system for hospital‐in‐the‐home patient identification

Internal Medicine Journal, EarlyView.
ABSTRACT Background Identification of appropriate patients for hospital‐in‐the‐home (HITH) remains a significant challenge. We hypothesise that a human‐centred design (HCD) approach can assist in developing a computerised clinical decision support system (CDSS) to address this issue via leveraging data within the electronic medical record (EMR).
Seok Ming Lim, Thomas Kitt‐Thompson, Douglas Forsyth Johnson, Michael Turner, Adam Boulton, Samantha Plumb, Daniel Capurro, Wen‐Kwang Lim   +7 more
wiley   +1 more source

The Effect of Cefepime/Fluorothiazinone Compared with Cefepime/Placebo on Clinical Cure and Microbiological Eradication in Patients with Complicated Urinary Tract Infections: A Prospective Randomized Clinical Trial

Антибиотики и Химиотерапия
The multicenter prospective randomized trial of clinical and microbiological efficacy of cefepime in combination with fluorothiazinone or placebo was conducted to expand the possibilities of empirical therapy for patients with complicated urinary tract ...
V. B. Beloborodov, N. A. Zigangirova, N. L. Lubenec, A. B. Sheremet, S. A. Nelyubina, N. E. Bondareva, S. I. Luyksaar, E. Yu. Levchenko, S. V. Luyksaar, E. A. Koroleva, E. D. Fedina, D. Yu. Pushkar, A. L. Gintsburg   +12 more
doaj   +1 more source

Infection Complications in Pediatric Patients With Inborn Errors of Immunity After Umbilical Cord Blood Transplantation: A Chinese Single‐Center Study

Transplant Infectious Disease, EarlyView.
This study reveals that infections are highly prevalent in pediatric IEI patients after umbilical cord blood transplantation, with early‐stage infections and bloodstream infections strongly associated with poorer survival. These findings advocate for risk‐stratified surveillance and preemptive strategies in high‐risk subgroups.
Zhongling Wei, Ping Wang, Wenjin Jiang, Jie Man, Ying Huang, Xiaochuan Wang, Hongsheng Wang, Xiaowen Qian, Xiaowen Zhai   +8 more
wiley   +1 more source

Resistance of Gram-Negative Bacteria to Cefepime-Enmetazobactam: A Systematic Review

Pathogens
Cefepime-enmetazobactam is a novel β-lactam/β-lactamase inhibitor combination showing good activity against multidrug-resistant (MDR) Gram-negative bacteria producing a variety of β-lactamases.
Matthew E. Falagas, Laura T. Romanos, Dimitrios S. Kontogiannis, Katerina Tsiara, Stylianos A. Kakoullis   +4 more
doaj   +1 more source

Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications

Molecules, 2016
The aim of our research activity was to obtain a biocompatible nanostructured composite based on naturally derived biopolymers (chitin and sodium alginate) loaded with commercial antibiotics (either Cefuroxime or Cefepime) with dual functions, namely ...
Marius Rădulescu, Alina Maria Holban, Laurențiu Mogoantă, Tudor-Adrian Bălşeanu, George Dan Mogoșanu, Diana Savu, Roxana Cristina Popescu, Oana Fufă, Alexandru Mihai Grumezescu, Eugenia Bezirtzoglou, Veronica Lazar, Mariana Carmen Chifiriuc   +11 more
doaj   +1 more source

No Increased Risk of Infection Following a Protocol Change to Decrease Duration of Perioperative Antibiotic Prophylaxis in Liver Transplantation

Transplant Infectious Disease, EarlyView.
There was no increased rate of surgical site infection or bacteremia in liver transplant recipients following a decrease in perioperative antibiotic prophylaxis duration, with a change from 2.4% to 2.8% in patients hospitalized prior to transplant and 7.5% to 2.9% in other patients.
Hutton Brandon, Crystal M. Truax, Eduardo Rodriguez Zarate, Brandon J. Tritle, Hannah Imlay   +4 more
wiley   +1 more source